[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625849":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":32,"responsibleParty":48,"collaborators":52,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":24,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":79,"whyStopped":24,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Centro Universitario La Salle","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Male participants","EXPERIMENTAL","Participants will perform a 30-minute aerobic exercise protocol on a lower-limb cycle ergometer at 70% heart rate reserve, including warm-up and cool-down periods.",[13],"Behavioral: Aerobic exercise using cycle ergometer",{"label":15,"type":10,"description":16,"interventionNames":17},"Female participants","Aerobic exercise using lower-limb cycle ergometer. Participants will perform the same aerobic exercise protocol.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Aerobic exercise using cycle ergometer","Participants will perform a 30-minute aerobic exercise protocol using a lower-limb cycle ergometer at 70% heart rate reserve. The protocol includes:\n\n* 5-minute warm-up\n* 20-minute exercise at target intensity\n* 5-minute cool-down Heart rate will be monitored continuously using a validated heart rate monitor.",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Álvaro Reina-Varona, MSc.","CONTACT","(+34) 91 740 19 80","506","alvaro.reina@lasallecampus.es",[33],{"facility":34,"status":24,"city":35,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Centro Superior de Estudios Universitarios La Salle","Madrid","28023","Spain","ES",{"type":40,"coordinates":41},"Point",[42,43],-3.70256,40.4165,{"lat":43,"lon":42},[46],{"name":47,"role":28,"phone":29,"phoneExt":30,"email":31},"Álvaro Reina Varona, MSc.",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Álvaro Reina Varona","Principal Investigator",[53],{"name":54,"class":6},"Universidad Rey Juan Carlos","100625849","sex-differences-in-exercise-induced-hypoalgesia-100625849",false,"NCT07427979","Sex Differences in Exercise-Induced Hypoalgesia","Sex Differences in Exercise-Induced Hypoalgesia Following Aerobic Exercise Using a Lower-Limb Cycle Ergometer: A Quasi-Experimental Study","Inclusion Criteria:\n\n* Healthy male and female adults\n* Age between 18 and 65 years\n* Able to perform moderate-to-vigorous aerobic exercise\n* Able to understand study procedures\n* Cleared for exercise participation using the Physical Activity Readiness Questionnaire (PAR-Q).\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, neurological, or metabolic diseases contraindicating exercise\n* Current musculoskeletal pain or injury\n* Analgesic medication use within 24 hours prior to testing\n* Vigorous exercise within 24 hours prior to testing\n* Any contraindication to aerobic exercise",true,"ALL","18 Years","65 Years",{"count":67,"type":68},30,"ESTIMATED","INTERVENTIONAL",[71],"NA","Exercise-induced hypoalgesia (EIH) refers to the reduction in pain sensitivity following acute exercise. Although aerobic exercise has been shown to induce hypoalgesia in healthy individuals, it remains unclear whether the magnitude of this response differs between men and women.\n\nThis quasi-experimental study aims to evaluate sex differences in pressure pain thresholds following a standardized aerobic exercise protocol using a lower-limb cycle ergometer. Pressure pain thresholds will be assessed before exercise, immediately after exercise, and 30 minutes after exercise in healthy adults aged 18 to 65 years.\n\nThe findings of this study may contribute to improving individualized exercise prescription strategies based on sex differences in pain modulation.",[74],"Healthy Adult",[76,77,78],"Exercise-Induced Hypoalgesia","Sex differences","Aerobic exercise","NOT_YET_RECRUITING","2026-03-16",{"date":82,"type":83},"2026-03-18","ACTUAL",{"date":85,"type":68},"2026-03-15",{"date":87,"type":68},"2026-07-15",{"name":5,"class":6},1]