[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100464792":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":29,"responsibleParty":45,"collaborators":49,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":18,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":31,"whyStopped":18,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"McMaster University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"High-fat test meal","EXPERIMENTAL","All participants will consume a high-fat breakfast after an overnight fast. This meal will consist of a flour tortilla, eggs, bacon, cheddar cheese, mayonnaise, and hashbrowns. After the initial blood sample (0 min) is drawn during Visit 2, we will ask participants to consume this breakfast within 10 minutes. This meal has been designed to mimic the amount of energy (calories) and fat contained in a typical fast-food breakfast (e.g., from Tim Hortons or McDonalds). Each meal will provide 846 kcal, derived from 54 g fat (58% energy), 61 g carbohydrate (29% energy), and 29 g protein (13% energy).",[13],"Other: High-fat test meal",[15],{"type":6,"name":9,"description":16,"armGroupLabels":17,"otherNames":18},"Ingestion of a mixed macronutrient breakfast meal providing 846 kcal, of which 58% is fat, 29% is carbohydrate and 13% is protein.",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Kirsten E Bell, PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":21,"role":25,"phone":26,"phoneExt":27,"email":28},"CONTACT","905-525-9140","24872","bellke3@mcmaster.ca",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Hamilton","Ontario","L8S 4K1","Canada","CA",{"type":38,"coordinates":39},"Point",[40,41],-79.84963,43.25011,{"lat":41,"lon":40},[44],{"name":21,"role":25,"phone":26,"phoneExt":27,"email":28},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Kirsten Bell","Assistant Professor",[50],{"name":5,"class":6},"100464792","sex-differences-in-metabolism-following-a-high-fat-meal-100464792",false,"NCT05332301","Sex Differences in Metabolism Following a High-fat Meal","Exploring Sex Differences in the Acute Postprandial Metabolic Response to a High-fat Mixed Macronutrient Meal Challenge in Healthy Young Humans","HFM","Inclusion Criteria:\n\n* BMI between 18.5 and 30.0 kg\u002Fm2\n* Weight stable for the past 6 months (± 2kg)\n* Exercise at or below the Canadian Physical Activity Guidelinesa\n* Fasting blood glucose \\\u003C6.0 mM\n* Resting blood pressure \\\u003C140\u002F90 mmHg\n* No hormone-altering contraceptive use (e.g., pill, patch, ring, injection)\n\nExclusion Criteria:\n\n* Smoking\n* Diabetes, cancer, or other metabolic disorders\n* Cardiac or gastrointestinal problems\n* Infectious disease\n* Barium swallow or nuclear medicine scan in the previous 3 weeks\n* Pregnant or breastfeeding\n* Diagnosis of polycystic ovary syndrome\n* Follow a vegan or vegetarian diet\n* Not fully vaccinated against COVID19",true,"ALL","18 Years","35 Years",{"count":64,"type":65},24,"ESTIMATED","INTERVENTIONAL",[68],"NA","Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (\\>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2 diabetes. Women tend to be better protected against the development of high-fat diet-induced insulin resistance compared with men, but it is not fully understand why this sex difference exists. It is possible that women metabolize high-fat meals differently than men, which might explain why they are less likely to develop type 2 diabetes over the course of their lifetime. However, no one has ever compared the metabolic response to a high-fat meal between men and women in the hours immediately after ingestion.\n\nDuring this study, the investigators will administer a single high-fat \"fast-food\" style breakfast meal (846 kcal, of which 58% is fat) to 24 health young adults (n=12 men, n=12 women) 18-35 years old. Their objective is to determine whether there are differences in the way men and women metabolize high-fat meals, such as this one. The research team will take regular blood samples after participants ingest this meal to measure features of glucose metabolism (e.g., blood glucose and insulin) as well as resting oxygen uptake (VO2) measurements to examine how much of this meal is burned for energy in the hours immediately after ingestion.",[71],"Healthy Nutrition",[73,74,75],"glucose metabolism","lipid metabolism","substrate oxidation","2025-08-14",{"date":78,"type":79},"2025-08-19","ACTUAL",{"date":81,"type":79},"2022-10-04",{"date":83,"type":65},"2027-05-30",{"name":47,"class":6},1]