[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625009":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":31,"locations":32,"responsibleParty":50,"collaborators":31,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":31,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":31,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":73,"overallStatus":34,"whyStopped":31,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Maastricht University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cannabis","EXPERIMENTAL","All participants will receive cannabis on 3 separate occasions during different phases of the menstrual cycle.",[13],"Drug: Cannabis",{"label":15,"type":16,"description":17,"interventionNames":18},"Knaster hemp","PLACEBO_COMPARATOR","All participants will receive knaster hemp on 3 separate occasions during different phases of the menstrual cycle.",[19],"Drug: Knaster Hemp",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Bedrobinol (13.5% THC) resulting in 300 μg\u002Fkg bodyweight THC, administered via a Storz and Bickel Mighty Medic vaporiser.",[9],[26],"Tetrahydrocannabinol",{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Knaster Hemp","Placebo will consist of knaster hemp, a freely sold aromatic herbal mixture for smoking. Participants will receive a dose of 50 mg of knaster hemp, administered via a Storz and Bickel Mighty Medic vaporiser.",[15],null,[33],{"facility":5,"status":34,"city":35,"state":31,"zip":31,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Maastricht","Netherlands","NL",{"type":39,"coordinates":40},"Point",[41,42],5.68889,50.84833,{"lat":42,"lon":41},[45],{"name":46,"role":47,"phone":48,"phoneExt":31,"email":49},"Natasha L Mason, PhD","CONTACT","+31 (0)43 388 1382","natasha.mason@maastrichtuniversity.nl",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Natasha Mason","Assistant Professor","100625009","sex-hormones-impact-on-cannabis-response-100625009",false,"NCT07417059","Sex Hormones Impact on Cannabis Response","The Influence of Female Sex Hormones on the Subjective and Cognitive Response to Cannabis","Inclusion Criteria:\n\n* Biological female\n* Used cannabis between 1 time a month and 2 times a week during the previous year\n* Age between 18 and 40 years\n* Free from psychotropic medication\n* Free from hormonal birth control\n* A regular menstrual cycle (last 3 cycles a duration between 21 and 35 days).\n* Good physical health as determined by medical examination and laboratory analysis\n* Absence of any major medical, endocrine and neurological condition as determined by medical examination and laboratory analysis\n* Normal weight, body mass index (weight\u002Fheight2) between 18 and 28 kg\u002Fm2\n* Written Informed Consent\n* Good knowledge and understanding of the English language\n* Participants must be willing to refrain from taking illicit psychoactive substances during the study.\n* Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drinks after midnight of the evening before the study session, as well as during the study day.\n* Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration.\n\nExclusion Criteria:\n\n* History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination)\n* Pregnancy or lactation or pregnancy planned during study participation\n* Hypertension (diastolic \\> 90 mmHg; systolic \\> 140 mmHg)\n* Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination)\n* Current presence or history of psychosis in first-degree relatives\n* Any chronic or acute medical condition\n* History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…)\n* Tobacco smoking (\\>20 per day)\n* Excessive drinking (\\>20 alcoholic consumptions per week)",true,"FEMALE","18 Years","40 Years",{"count":66,"type":67},21,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this study is to systematically determine whether the cannabis response in human females is related to SH fluctuations throughout the menstrual cycle.",[9],[74,75,76],"sex hormones","cannabis","THC","2026-02-10",{"date":79,"type":80},"2026-02-18","ACTUAL",{"date":82,"type":80},"2025-06-01",{"date":84,"type":67},"2026-12-31",{"name":5,"class":6},1]