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unknown) group: routine follow-up and spontaneous delivery",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Intervention group or reveal group","EXPERIMENTAL","A ratio cutoff of \\>p90th will be used to define low and elevated risk of developing a placental complications of pregnancy and therefore induction of labour will be offered from 37th weeks of gestation",[18],"Diagnostic Test: sFlt1\u002FPlGF screening in maternal blood at 35 to 36.6 weeks of gestation",[20],{"type":21,"name":22,"description":16,"armGroupLabels":23,"otherNames":12},"DIAGNOSTIC_TEST","sFlt1\u002FPlGF screening in maternal blood at 35 to 36.6 weeks of gestation",[14],[25],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},"Elisa Llurba, MD; 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Medicine","Warsaw","Poland","PL",{"type":38,"coordinates":151},[152,153],21.01178,52.22977,{"lat":153,"lon":152},{"facility":156,"status":33,"city":157,"state":158,"zip":12,"country":159,"countryCode":160,"cosmosGeoPoint":161,"geoPoint":165,"contacts":12},"Hospital Germans Trias i Pujol","Badalona","Barcelona","Spain","ES",{"type":38,"coordinates":162},[163,164],2.24741,41.45004,{"lat":164,"lon":163},{"facility":167,"status":168,"city":169,"state":170,"zip":12,"country":159,"countryCode":160,"cosmosGeoPoint":171,"geoPoint":175,"contacts":12},"Complejo Hospitalario Universitario Insular Materno Infantil","WITHDRAWN","Las Palmas de Gran Canaria","Canary Islands",{"type":38,"coordinates":172},[173,174],-15.41573,28.10178,{"lat":174,"lon":173},{"facility":177,"status":33,"city":178,"state":179,"zip":180,"country":159,"countryCode":160,"cosmosGeoPoint":181,"geoPoint":185,"contacts":12},"Virgen de la Arrixaca","El 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Fe","Valencia",{"type":38,"coordinates":234},[235,236],-0.37966,39.47391,{"lat":236,"lon":235},{"facility":239,"status":168,"city":240,"state":12,"zip":12,"country":159,"countryCode":160,"cosmosGeoPoint":241,"geoPoint":245,"contacts":12},"Hospital Lozano Blesa","Zaragoza",{"type":38,"coordinates":242},[243,244],-0.87734,41.65606,{"lat":244,"lon":243},{"type":81,"investigatorFullName":247,"investigatorTitle":248,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Elisa Llurba","Professor of Obstetric and Gynecology Universitat Autònoma de Barcelona",[250],{"name":251,"class":6},"Fundacion Clinic per a la Recerca Biomédica","100421367","sflt1plgf-and-planned-delivery-to-prevent-preeclampsia-at-term-100421367",false,"NCT04766866","sFlt1\u002FPlGF and Planned Delivery to Prevent Preeclampsia at Term.","Protocol of the PE37 Study: A Multicenter Randomized Trial of Screening With sFlt1\u002FPlGF and Planned Delivery to Prevent Preeclampsia at Term","PE37","Inclusion Criteria:\n\n* Nulliparous women\n* Singleton pregnancies\n* \\>18 years old\n* 35.0-36.6 weeks of gestation\n* Maternal written consent form\n\nExclusion Criteria:\n\n* Fetuses\u002Fneonates with major malformations or genetic anomalies that could modify the timing of delivery or has an impact on obstetric outcome\n* Suspected fetal growth restriction (estimated fetal weight \\\u003C3 centile or between the 3rd and 10th centile together with abnormal Doppler in the mean uterine artery Doppler pulsatility index, or in umbilical artery pulsatility index or in the middle cerebral artery or in the cerebral umbilical index (CPR))\n* Participation in another interventional study that could modify the timing of delivery.",true,"FEMALE","18 Years",{"count":264,"type":265},9132,"ESTIMATED","INTERVENTIONAL",[268],"NA","* Preeclampsia (PE) affects \\~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.\n* Term PE accounts for 70% of all PE and a large proportion of maternal-fetal morbidity related with this condition. Prediction and prevention of term PE remains unsolved.\n* Previously proposed approaches are based on combined screening and\u002For prophylactic drugs, but these policies are unlikely to be implementable in many world settings.\n* Recent evidence shows that sFlt1-PlGF ratio at 35-37w predicts term PE with 80% detection rate.\n* Likewise, recent studies demonstrate that induction of labor (IOL) from 37w is safe.\n* The investigators hypothesize that a single-step universal screening for term PE based on sFlt1\u002FPlGF ratio at 35-37w followed by IOL from 37w would reduce the prevalence of term PE without increasing cesarean section rates or adverse neonatal outcomes.\n* The investigators propose a randomized clinical trial to evaluate the impact of a screening of term PE with sFlt-1\u002FPlGF ratio in asymptomatic nulliparous women at 35-37w. Women will be assigned to revealed (sFlt-1\u002FPlGF known to clinicians) versus concealed (unknown) arms. A cutoff of \\>90th centile will be used to define high risk of PE and offer IOL from 37w.\n* If successful, the results of this trial will provide evidence to support a simple universal screening strategy reducing the prevalence of term PE, which could be applicable in most healthcare settings and have enormous implications on perinatal outcomes and public health policies worldwide.",[271,272,273,274,275],"Preeclampsia","Intrauterine Growth Restriction","Maternal Hypertension","Neonatal Outcome","Perinatal Death",[277],"Preeclampsia, angiogenic factors, perinatal death, induction of labour","2025-02-17",{"date":280,"type":281},"2025-02-19","ACTUAL",{"date":283,"type":281},"2021-03-02",{"date":285,"type":265},"2026-12-31",{"name":5,"class":6},21]