[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630421":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":26,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":26,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":26,"overallStatus":73,"whyStopped":26,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University of California, Davis","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active iTBS","EXPERIMENTAL","The active iTBS group will receive 10 hourly intermittent theta burst stimulation (iTBS) sessions per day for 5 consecutive days.",[13],"Device: intermittent theta burst stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham iTBS","SHAM_COMPARATOR","Participants assigned to the sham group will receive 10 hourly sham sessions per day for 5 consecutive days.",[19],"Device: Sham (No Treatment)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","intermittent theta burst stimulation","The TMS protocol involves delivering sessions of intermittent theta burst stimulation (iTBS) of 60 cycles of 10 bursts of three pulses at 50 Hz delivered in 2-second trains (5 Hz) with an 8-second intertrain interval. Stimulation sessions will be delivered hourly. Ten sessions will be applied per day (18,000 pulses\u002Fday) for 5 consecutive days (90,000 pulses in total). Stimulation will be delivered at 90% resting motor threshold (rMT). For safety, stimulation will never be delivered above 120% rMT. Participants assigned to the sham group will receive treatment using a sham TMS coil.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham (No Treatment)","Participants assigned to the sham group will receive treatment using a sham TMS coil. This coil looks and sounds similar to the active coil but does not deliver magnetic pulses to the brain.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Manpreet K Singh, MD, MS","CONTACT","916-734-2011","mpksingh@health.ucdavis.edu",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"UC Davis Medical Center","Sacramento","California","95817","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-121.4944,38.58157,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100630421","sham-controlled-rapid-acting-neuromodulation-for-depression-100630421",false,"NCT07487454","Sham-Controlled Rapid-Acting Neuromodulation for Depression","Inclusion Criteria:\n\n* English speaking\n* Able to provide informed consent\n* 18-65 years old\n* Meets MDD criteria per the Mini International Neuropsychiatric Interview (MINI)\n\nExclusion Criteria:\n\n* Unable to consent (due to medical condition, acute psychosis, substance use, etc)\n* Use of benzodiazepines or medications that would interfere with TMS treatment as per PI discretion\n* Active substance use or severe substance use that in the opinion of the PI would interfere with study participation\n* Untreated, active psychosis\n* Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study\n* Contraindications to receiving TMS and\u002For MRI as determined by screening questionnaires\n* Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies.","ALL","18 Years","65 Years",{"count":65,"type":66},264,"ESTIMATED","INTERVENTIONAL",[69],"NA","The goal of this study is to learn whether 5 days of accelerated intermittent theta burst stimulation (iTBS), a rapid form of transcranial magnetic stimulation (TMS), which is a non-invasive procedure that uses magnetic fields to stimulate brain activity, works to treat depression in adults.\n\nThe main questions it aims to answer are:\n\n* Does accelerated iTBS reduce depressive symptoms compared to sham (placebo) stimulation?\n* Are there measurable brain, biological, and digitally measured emotion changes associated with treatment response?\n\nParticipants will:\n\n* Be randomly assigned to receive either active iTBS or sham stimulation\n* Receive 10 stimulation sessions per day for 5 consecutive days (total of 50 sessions)\n* Complete MRI brain scans and EEG recordings before and after treatment\n* Provide blood and saliva samples to measure biological markers\n* Complete depression rating scales and questionnaires at baseline, during treatment, and at follow-up visits\n* Use a secure mobile app to record brief facial and vocal samples during the 5-day treatment and at follow-up visits\n* Return for follow-up visits at 1 week and at 1, 3, 6, and 12 months after treatment",[72],"Depression - Major Depressive Disorder","NOT_YET_RECRUITING","2026-06-12",{"date":76,"type":77},"2026-06-16","ACTUAL",{"date":79,"type":66},"2026-12",{"date":81,"type":66},"2028-05",{"name":5,"class":6},1]