[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621525":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":26,"locations":10,"responsibleParty":35,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":44,"sex":45,"minAge":46,"maxAge":10,"enrollmentInfo":47,"targetDuration":50,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"Groupe Hospitalier du Havre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy adults",null,"Participant without respiratory, muscle or thoracic abnormalities",[13],"Diagnostic Test: Intercostal muscle shear wave elastography (SWE) during standardized inspiratory loading",{"label":15,"type":10,"description":16,"interventionNames":17},"COPD group","Patients with COPD",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Intercostal muscle shear wave elastography (SWE) during standardized inspiratory loading","Ultrasound shear wave elastography (SWE) is performed to quantify intercostal muscle stiffness at rest and during standardized inspiratory loading\u002Fcontrolled breathing. SWE acquisitions are synchronized with physiological reference recordings (e.g., esophageal pressure and\u002For diaphragm EMG when available) to estimate and track respiratory effort\u002Fwork noninvasively.",[15,9],[25],"Ultrasound shear wave elastography of intercostal muscles",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Clément Medrinal","CONTACT","+33664615110","medrinal.clement.mk@gmail.com",{"name":33,"role":29,"phone":10,"phoneExt":10,"email":34},"Angélique Picard","Angelique.picard@ch-havre.fr",{"type":36,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100621525","shear-wave-elastography-of-intercostal-muscles-for-the-non-invasive-assessment-of-the-work-of-breathing-100621525",false,"NCT07371754","Shear Wave Elastography of Intercostal Muscles for the Non-invasive Assessment of the Work of BreathinG","SWING","Inclusion Criteria:\n\nAdult patient with chronic obstructive pulmonary disease (COPD), stage 3-4.\n\nHealthy adult volunteer.\n\nExclusion Criteria:\n\nRefusal to participate or withdrawal of consent.\n\nAge \\\u003C 18 years.\n\nBMI \\> 35 kg\u002Fm².\n\nPregnancy or breastfeeding.\n\nInability to understand instructions or cooperate (cognitive impairment, language barrier).\n\nNeurological condition affecting breathing (e.g., recent stroke, ALS, myopathy).\n\nThoracic condition limiting access to the intercostal muscles (e.g., major chest wall deformity, surgical scar).\n\nRecent thoracic or abdominal surgery (\\\u003C 3 months).\n\nKnown esophageal disease (stricture, achalasia, severe esophagitis, diverticulum, history of perforation).\n\nENT or tracheal abnormality preventing probe insertion (e.g., tumor, malformation, tracheostomy).\n\nSwallowing disorders or risk of aspiration.\n\nRecent exacerbation (\\\u003C 6 weeks).\n\nOxygen therapy \\> 2 L\u002Fmin during exertion.\n\nHemodynamic instability.\n\nNot affiliated with a social security scheme.\n\nLegally protected persons (as defined by law).",true,"ALL","18 Years",{"count":48,"type":49},20,"ESTIMATED","1 Day","OBSERVATIONAL","Quantifying respiratory effort is a key step in physiological and clinical research on exercise tolerance, mechanisms of fatigability, and ventilatory impairment. To date, reliable assessment relies on an invasive method: esophageal pressure (Pes) measurement using a balloon catheter inserted into the esophagus. Although Pes provides an indirect estimate of pleural and intrathoracic pressure, it is uncomfortable for patients, requires dedicated equipment, and may limit study participation.\n\nIn critically ill patients, a noninvasive approach to quantify respiratory effort would have major clinical and scientific value. In acute respiratory distress, accurately tracking the intensity and evolution of respiratory effort could support earlier therapeutic decision-making.\n\nShear Wave Elastography (SWE) is an ultrasound technology enabling very high acquisition rates and estimating tissue stiffness from shear-wave propagation induced by an acoustic impulse. Because muscle stiffness is strongly related to force produced during contraction, we hypothesize that intercostal muscle stiffness measured by SWE correlates with respiratory work and increases with rising inspiratory load.",[54,55],"COPD","Healthy Adult",[57,58,59],"Shear wave elastography","Intercostal muscles","work of breathing","NOT_YET_RECRUITING","2026-01-19",{"date":63,"type":64},"2026-01-28","ACTUAL",{"date":66,"type":49},"2026-03-01",{"date":68,"type":49},"2027-03-01",{"name":5,"class":6}]