[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642676":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"First Affiliated Hospital of Wannan Medical College","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ICU Patients on Mechanical Ventilation",null,"A cohort of adult patients newly admitted to the ICU who are receiving mechanical ventilation and are at risk for developing ICU-Acquired Weakness.",[13],"Diagnostic Test: Nerve Ultrasound with Shear Wave Elastography",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Nerve Ultrasound with Shear Wave Elastography","Patients will undergo non-invasive ultrasound examinations of the median nerve and tibial nerve at the bedside on days 1, 4, and 7. The examination includes Shear Wave Elastography (SWE) to quantify nerve stiffness (elasticity) and B-mode imaging to measure nerve cross-sectional area (CSA). This is a purely observational procedure and does not alter patient management.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"qiancheng xu, PhD","CONTACT","+86-18297529106","xu19871011@163.com",[27],{"facility":28,"status":10,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)","Wuhu","Anhui","241001","China","CN",{"type":35,"coordinates":36},"Point",[37,38],118.42947,31.35259,{"lat":38,"lon":37},[41],{"name":42,"role":23,"phone":43,"phoneExt":10,"email":44},"Shengsheng Tao","86-18315329399","taoshengsheng@yjsyy.com",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Qiancheng Xu","Principal Investigator","100642676","shear-wave-elastography-of-peripheral-nerves-for-early-diagnosis-of-icu-acquired-weakness-100642676",false,"NCT07594249","Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired Weakness","Clinical Value of Shear Wave Elastography of Peripheral Nerves for the Early Diagnosis of ICU-Acquired Weakness: A Prospective Observational Pilot Study","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. Newly admitted to ICU with an expected ICU stay \\> 7 days;\n3. Initiated on mechanical ventilation within 24 hours of admission, with an expected ventilation duration \\> 48 hours;\n4. Patient or legally authorized representative provides written informed consent.\n\nExclusion Criteria:\n\n1. Known pre-existing neuromuscular diseases (e.g., myasthenia gravis, Guillain-Barré syndrome, amyotrophic lateral sclerosis);\n2. Pre-existing limb dysfunction that would interfere with muscle strength assessment (e.g., hemiplegia, paraplegia, severe arthritis);\n3. Presence of acute trauma, surgery, skin breakdown, infection, or severe edema at the measurement sites (wrist, elbow, ankle) that would interfere with ultrasound probe placement;\n4. Pregnant or lactating women;\n5. Any other condition that the investigator believes would make the patient unsuitable for the study.","ALL","18 Years","85 Years",{"count":60,"type":61},98,"ESTIMATED","28 Days","OBSERVATIONAL","This study aims to determine whether shear wave elastography (SWE), a non-invasive ultrasound technique that measures nerve stiffness, can help detect ICU-acquired weakness (ICU-AW) early in critically ill patients. Adults receiving mechanical ventilation in the ICU will undergo ultrasound examinations of the median and tibial nerves on Days 1, 4, and 7. The study will evaluate whether early changes in nerve elasticity can predict ICU-AW, which is usually diagnosed later using a muscle strength score that requires patient cooperation.",[66,67,68],"ICU-acquired Weakness","Critical Illness Polyneuropathy","Critical Illness Myopathy",[70,71,72,73,74],"Shear Wave Elastography","Peripheral Nerve","Ultrasonography","Critical Care","Early Diagnosis","NOT_YET_RECRUITING","2026-06-13",{"date":78,"type":79},"2026-06-16","ACTUAL",{"date":81,"type":61},"2026-07-01",{"date":83,"type":61},"2027-06-30",{"name":5,"class":6},1]