[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594820":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":26,"centralContacts":35,"locations":41,"responsibleParty":63,"collaborators":26,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":26,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":26,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Zhongda Hospital","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Sigh Ventilation","EXPERIMENTAL","sigh breaths, low tidal volume and moderate PEEP levels",[13,14,15],"Other: Sigh Breaths","Other: Low Tidal Volume","Other: Moderate PEEP",{"label":17,"type":18,"description":19,"interventionNames":20},"Conventional Ventilation","ACTIVE_COMPARATOR","low tidal volume, moderate PEEP levels",[14,15],[22,27,31],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"Sigh Breaths","Sigh breaths were added by elevating PEEP, targeting a plateau pressure of 35 cmH2O (or 40 cmH2O for patients with a Body Mass Index \\> 35 kg\u002Fm2). These sigh breaths were administered once every 6 minutes at predefined stages in the perioperative period from the time of anesthesia intubation until endotracheal extubation, postoperative day 7, or death, whichever occurred first, but not during transport. Each sigh consisted of the minimum number of respiratory cycles aimed to achieve a total duration of at least 5 seconds, based on the respiratory cycle duration preset on the ventilator.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Low Tidal Volume","6-8ml\u002Fkg predicted body weight",[17,9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"Moderate PEEP","PEEP set according to ARDSnet low PEEP- fraction of inspired oxygen table, FiO2 was set as the lowest fraction targeted to maintain SpO2 ≥ 96%",[17,9],[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Zhichang Wang","CONTACT","+8618255127433","wang15zc@163.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Zhongda Hospital, Southeast University","RECRUITING","Nanjing","Jiangsu","210009","China","CN",{"type":51,"coordinates":52},"Point",[53,54],118.77778,32.06167,{"lat":54,"lon":53},[57,60],{"name":58,"role":38,"phone":59,"phoneExt":26,"email":40},"Zhichang Wang, M.D.","+8615261887038",{"name":61,"role":62,"phone":26,"phoneExt":26,"email":26},"Fengmei Guo, Ph.D, M.D","PRINCIPAL_INVESTIGATOR",{"type":62,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Fengmei Guo","Deputy director","100594820","sigh-ventilation-in-cardiac-surgery-100594820",false,"NCT07024420","Sigh Ventilation in Cardiac Surgery","Effect of Sigh Ventilation on Postoperative Pulmonary Complications in Cardiac Surgery: A Multicenter, Randomized Controlled Trial","Inclusion Criteria:\n\n* 18 years of age or older;\n* Elective cardiac surgery with cardiopulmonary bypass, aortic clamp and cardioplegia;\n* Written informed consent is obtained from patients and\u002For their legal representatives.\n\nExclusion Criteria:\n\n* Emergence surgery;\n* Left ventricular assist device implantation;\n* Planned thoracotomy with one lung ventilation;\n* Undergo concurrent surgical procedures outside cardiology;\n* Neuromuscular illness;\n* Mechanical ventilation within the last 2 weeks before surgery, include CPAP and NIV;\n* Preoperative shock;\n* Preoperative Hypoxemia (PaO2\\\u003C60mmHg OR SpO2\\\u003C90% on ambient air);\n* Preoperative left ventricular ejection fraction \\\u003C 40%;\n* Systolic pulmonary artery pressure \\> 50 mmHg.","ALL","18 Years",{"count":76,"type":77},686,"ESTIMATED","INTERVENTIONAL",[80],"NA","The purpose of this trial is to investigate whether sigh ventilation strategy, combining sigh breaths, low tidal volume, and moderate PEEP levels, protects against major pulmonary complications within the first 7 postoperative days after cardiac surgery, as compared with conventional ventilation strategy with low tidal volume, and moderate PEEP levels.",[83,84],"Postoperative Pulmonary Complications (PPCs)","Cardiac Surgery in Adult Patient",[9,86,87],"Cardiac Surgery","Postoperative Pulmonary Complications","2025-11-14",{"date":90,"type":91},"2025-11-18","ACTUAL",{"date":93,"type":91},"2025-10-09",{"date":95,"type":77},"2027-12-31",{"name":5,"class":6},1]