[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643211":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":43,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":67,"overallStatus":78,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Cleveland Clinic Abu Dhabi","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ICU Patients Following Prolonged Mechanical Ventilation",null,"Adult ICU patients intubated for 5 days or longer undergoing bedside swallow screening and Fiberoptic Endoscopic Evaluation of Swallowing (FEES) within 72 hours after extubation to assess silent aspiration",[13],"Diagnostic Test: Fiberoptic Endoscopic Evaluation of Swallowing (FEES)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Fiberoptic Endoscopic Evaluation of Swallowing (FEES)","FEES will be performed within 72 hours after extubation to assess swallowing function and detect silent aspiration in ICU patients following prolonged mechanical ventilation.",[9],[21],{"name":22,"affiliation":5,"role":23},"Jihad Mallat, MD, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","+97125019000","mallatj@ccad.ae",[30],{"facility":5,"status":10,"city":31,"state":10,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Abu Dhabi","United Arab Emirates","AE",{"type":35,"coordinates":36},"Point",[37,38],54.39696,24.45118,{"lat":38,"lon":37},[41],{"name":42,"role":26,"phone":27,"phoneExt":10,"email":28},"Jihad Mallat, MD PhD",{"type":23,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jihad Mallat","Critical Care Consultant","100643211","silent-aspiration-following-extubation-in-the-icu-100643211",false,"NCT07635888","Silent Aspiration Following Extubation in the ICU","Incidence, Risk Factors, and Outcomes of Silent Aspiration Post Extubation in the ICU","SAFE-ICU","Inclusion Criteria:\n\n* Adult ICU patients requiring invasive mechanical ventilation for 5 days or longer\n* Successful extubation after invasive mechanical ventilation\n* Undergoing bedside nursing swallow screening after extubation\n* Ability to undergo Fiberoptic Endoscopic Evaluation of Swallowing (FEES) within 72 hours after extubation\n* Provision of informed consent by the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Presence of tracheostomy\n* Do-not-reintubate orders\u002FAllow natural death\n* Pregnancy\n* Absence of informed consent\n* Contraindication to FEES as determined by the treating physician (e.g., high bleeding risk or severe oxygen requirements)","ALL","18 Years",{"count":57,"type":58},274,"ESTIMATED","OBSERVATIONAL","Post-extubation dysphagia is common in critically ill patients and may lead to silent aspiration, which often remains undetected because patients do not exhibit overt clinical signs such as coughing or choking. Current bedside nursing swallow screening may fail to identify silent aspiration in patients recovering from prolonged mechanical ventilation.\n\nThe goal of this observational study is to learn about the incidence, risk factors, and clinical outcomes of silent aspiration in critically ill adult patients who require prolonged mechanical ventilation and are extubated in the ICU. The main questions it aims to answer are:\n\n* How often does silent aspiration occur in ICU patients intubated for 5 days or longer after extubation?\n* Can silent aspiration be present despite passing the routine bedside nursing swallow screen?\n* What clinical factors are associated with silent aspiration?\n* Is silent aspiration associated with worse clinical outcomes such as aspiration pneumonia, reintubation, prolonged ICU stay, ventilator-free days, or mortality? Participants who have been mechanically ventilated for 5 days or more will undergo routine bedside swallow screening followed by Fiberoptic Endoscopic Evaluation of Swallowing (FEES), considered the gold-standard diagnostic tool for detecting silent aspiration, within 72 hours after extubation. Researchers will compare bedside nursing swallow screening results with FEES findings to evaluate the diagnostic accuracy of bedside screening in detecting silent aspiration. Clinical data, swallowing assessment findings, and patient outcomes will also be collected and analyzed.",[62,63,64,65,66],"Silent Aspiration","Post-Extubation Dysphagia","Deglutition Disorders","Critical Illness","Mechanical Ventilation Complication",[68,69,70,71,72,73,74,75,76,77],"Silent aspiration","ICU extubation","Post-extubation dysphagia","FEES","Fiberoptic Endoscopic Evaluation of Swallowing","Mechanical ventilation","Swallow screening","Aspiration pneumonia","Critical care","Dysphagia screening","NOT_YET_RECRUITING","2026-06-03",{"date":81,"type":82},"2026-06-09","ACTUAL",{"date":84,"type":58},"2026-06",{"date":86,"type":58},"2028-06",{"name":5,"class":6},1]