[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600680":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":10,"responsibleParty":18,"collaborators":10,"id":22,"slug":23,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":27,"acronym":9,"eligibilityCriteria":28,"healthyVolunteers":29,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":10,"studyType":36,"phases":10,"briefSummary":37,"conditions":38,"keywords":40,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":10},{"fullName":5,"class":6},"Institute for Human Development and Potential (IHDP), Singapore","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"SG-PRIME",null,"no interventions",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Narasimhan Kothandaraman, Ph.D","CONTACT","+65 64074057","Kothandaraman_Narasimhan@sics.-astar.edu.sg",{"type":19,"investigatorFullName":20,"investigatorTitle":21,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Kothandaraman Narasimhan, Ph.D.","Principal Investigator","100600680","singapore-population-research-on-integrated-exposome--early-menopause-100600680",false,"NCT07100639","Singapore Population Research on Integrated exposoMe & Early Menopause","From Exposome to Health Outcomes: A Population-Based Approach to Understanding and Mitigating Early Menopause in Singapore's Diverse Communities","Inclusion Criteria:\n\nFemale participants aged 40-50 years No menstruation for the last 2 months or irregular menstrual cycles in the last 6 months Chinese, Malay, or Indian ethnicity Proficient in English language Planning to reside in Singapore for next 2 years Willing to provide informed consent and comply with study procedures\n\nExclusion Criteria:\n\nIn menopause (12 consecutive months without menstruation) Currently pregnant or planning to conceive History of bilateral oophorectomy and\u002For hysterectomy Currently receiving hormone therapy, including estradiol replacement therapy or oral contraceptives Diagnosed with premature ovarian insufficiency before 40 years of age Diagnosis of autoimmune conditions and\u002For chromosomal abnormalities known to affect ovarian function Diagnosis of severe cognitive impairment and\u002For mental disorders Received cancer treatment in the past 12 months",true,"FEMALE","40 Years","50 Years",{"count":34,"type":35},400,"ESTIMATED","OBSERVATIONAL","Brief Summary\n\nThe goal of this observational study is to learn how environmental factors, lifestyle choices, and social conditions affect the timing of menopause in Asian women aged 40-50 years living in Singapore. The main aims of the project are the following:\n\n* Do environmental pollutants and lifestyle exposures contribute to earlier menopause in Asian women?\n* What biological changes occur when women are exposed to harmful environmental factors during menopause transition?\n\nParticipants will be followed for 18 months and will complete questionnaires about their health history, lifestyle, diet, and environmental exposures. Participants will provide blood, urine, stool, hair, and nail samples for laboratory analysis and undergo basic health assessments including weight, blood pressure, and bone density measurements. Participants will wear activity monitors and air pollution sensors for 7 days and attend follow-up visits at 6 months, 12 months, and 18 months to track changes in their health. This data will be obtained during the baseline visit.",[39],"Early Menopause",[41,42,43,44],"early menopause","environment","pollution","exposome","NOT_YET_RECRUITING","2025-07-27",{"date":48,"type":49},"2025-08-03","ACTUAL",{"date":51,"type":35},"2025-08-06",{"date":53,"type":35},"2028-04-01",{"name":5,"class":6}]