[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613358":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":10,"centralContacts":37,"locations":43,"responsibleParty":62,"collaborators":64,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":10,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":10,"maxAge":10,"enrollmentInfo":81,"targetDuration":84,"studyType":85,"phases":10,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Nanfang Hospital, Southern Medical University","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal group",null,"Age groups are divided into minors (\\\u003C18 years old), young adults (18-50 years old), and the elderly (\\>65 years old).",[13,14],"Procedure: Collection of Preoperative Peripheral Blood","Procedure: Collection of Discarded Liver Tissue During Surgery",{"label":16,"type":10,"description":17,"interventionNames":18},"Fatty liver group","Fatty liver groups are categorized based on the degree of hepatic steatosis into mild, moderate, and severe fatty liver groups.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Liver fibrosis group","Liver fibrosis groups are distinguished according to the stage of hepatic fibrosis into mild, moderate, and severe liver fibrosis groups.",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"hepatitis B virus infection","Patients with hepatitis B virus (HBV) infection",[13,14],[28,33],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"PROCEDURE","Collection of Preoperative Peripheral Blood","Prior to surgery, 30 milliliters of peripheral blood will be drawn from the subject's upper limb.",[16,20,9,24],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":10},"Collection of Discarded Liver Tissue During Surgery","From subjects undergoing hepatectomy or liver biopsy, discarded liver tissue will be collected during the surgical procedure.",[16,20,9,24],[38],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Yongyin Li, Dr.","CONTACT","+8613826039505","yongyinli@foxmail.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Nan","RECRUITING","Guangzhou","Guangdong","510515","China","CN",{"type":53,"coordinates":54},"Point",[55,56],113.25,23.11667,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":61,"phoneExt":10,"email":42},"Yongyin Li","13826039505",{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[65,67,69,71],{"name":66,"class":6},"Beijing Friendship Hospital",{"name":68,"class":6},"Beijing YouAn Hospital",{"name":70,"class":6},"Zhongnan Hospital",{"name":72,"class":6},"Guangzhou General Hospital of Guangzhou Military Command","100613358","single-cell-multiomics-and-spatiotemporal-omics-analyze-the-mechanism-of-liver-degenerative-disease-100613358",false,"NCT07265544","Single-cell Multiomics and Spatiotemporal Omics Analyze the Mechanism of Liver Degenerative Disease","Inclusion Criteria:\n\n1. Voluntarily signed the informed consent form;\n2. No restrictions on age and gender;\n3. Patients diagnosed with hepatic hemangioma or focal nodular hyperplasia of the liver in accordance with the \"Guidelines for the Diagnosis and Treatment of Focal Liver Lesions (2014 Edition)\" and the \"Guidelines for the Diagnosis and Treatment of Hemangiomas and Vascular Malformations (2019 Edition)\";\n4. Patients with hepatic hemangioma, focal nodular hyperplasia of the liver, fatty liver, HBV infection, liver fibrosis, and cirrhosis who clinically require liver surgery or liver biopsy.\n\nExclusion Criteria:\n\n1. Individuals with concurrent infections such as HIV will be excluded.\n2. Patients with coagulation system disorders, such as hemophilia or idiopathic thrombocytopenic purpura, will not be included.\n3. Those with severe underlying diseases that affect the body's immune status will be excluded.\n4. Individuals whom the investigator deems unsuitable for participation in this study will be excluded.",true,"ALL",{"count":82,"type":83},240,"ESTIMATED","7 Days","OBSERVATIONAL","The purpose of this observational study is to employ single-cell multi-omics and spatial omics technologies to characterize the spatial and immune structures within the livers of patients with fatty liver, hepatic hemangioma, focal nodular hyperplasia, liver fibrosis, cirrhosis, and HBV infection. The primary questions it aims to address are:\n\nInvestigate the mechanisms of liver degenerative changes during the processes of liver aging, fatty liver, HBV infection, liver fibrosis, and cirrhosis.\n\nCharacterize the molecular features and cellular networks at different stages of liver degeneration and identify new targets and mechanisms for the cure of the aforementioned diseases.\n\nThe study will collect peripheral blood and discarded liver tissue from patients with hepatic hemangioma, fatty liver, HBV infection, liver fibrosis, and cirrhosis who are undergoing hepatectomy or liver biopsy.",[88,89,90,91],"Liver Neoplasm","HBV Infection","Non-alcoholic Fatty Liver Disease NAFLD","Liver Fibrosis",[93,94,95],"single-cell multi-omics","HBV infection","liver degenerative changes","2026-04-13",{"date":98,"type":99},"2026-04-14","ACTUAL",{"date":101,"type":99},"2023-03-01",{"date":103,"type":83},"2027-02-12",{"name":5,"class":6},1]