[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558916":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":20,"responsibleParty":69,"collaborators":10,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":10,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":54,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"NHS Lothian","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Bronchoscopy under ELFMAN",null,"Clinical bronchoscopy performed under ELMAN study",[13],"Diagnostic Test: Single Cell Sequencing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Single Cell Sequencing","Sequencing of all viable single cells present in deep bronchial brushings using transcriptomics to identify what cells are present and what they are doing.",[9],[21,40,52],{"facility":22,"status":23,"city":24,"state":10,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Centre for Information Research, University of Edinburgh","NOT_YET_RECRUITING","Edinburgh","EH16 4UU","United Kingdom","UK",{"type":29,"coordinates":30},"Point",[31,32],-3.19648,55.95206,{"lat":32,"lon":31},[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Nik Hirani, MBBS","CONTACT","01312421836","n.hirani@ed.ac.uk",{"facility":41,"status":23,"city":24,"state":10,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":42,"geoPoint":44,"contacts":45},"Henderson Lab",{"type":29,"coordinates":43},[31,32],{"lat":32,"lon":31},[46,49],{"name":47,"role":37,"phone":10,"phoneExt":10,"email":48},"Neil Henderson","neil.henderson@ed.ac.uk",{"name":50,"role":37,"phone":10,"phoneExt":10,"email":51},"Prasad Velu","ppalani@exseed.ed.ac.uk",{"facility":53,"status":54,"city":24,"state":10,"zip":55,"country":26,"countryCode":27,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"Edinburgh Cancer Centre","RECRUITING","EH4 2XU",{"type":29,"coordinates":57},[31,32],{"lat":32,"lon":31},[60,65],{"name":61,"role":37,"phone":62,"phoneExt":63,"email":64},"Stephen J Harrow, MB ChB","01315371000","32111","stephen.harrow2@nhs.scot",{"name":66,"role":37,"phone":62,"phoneExt":67,"email":68},"Stuart R Walter, BMBS","31777","stuart.walter@nhs.scot",{"type":70,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100558916","single-cell-sequencing-analysis-of-radiation-pneumonitis-signals-in-patients-treated-for-cancer-with-radiotherapy-100558916",false,"NCT06557343","Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy","SPITFIRE","Inclusion Criteria:\n\n* Age over 18 years\n* Patient has received thoracic radiotherapy and has clinical or radiological features in fitting with a diagnosis of Radiation Pneumonitis (onset one to four months post-RT with breathlessness, especially exertional, cough, chest discomfort, which is persistent over weeks, a chest x-ray \\[CXR\\] may demonstrate patchy or widespread opacification although can be normal.)\n* Must be ambulant, oxygen independent with SpO2 \\>92% on air and haemodynamically stable to be considered safe for a bronchoscopy.\n* Willing to undergo and likely able to tolerate bronchoscopy, ie. Can lie flat without compromising ventilation, and able to consent to the ELFMAN Protocol and SPITFIRE trial.\n\nExclusion Criteria:\n\n* Contraindication to bronchoscopy, ie. Previously not tolerated, unable to lie flat, Sp02 \\\u003C92% on air\n* Patient requires admission or oxygen dependant\n* Test positive for Covid-19 within the preceding six weeks to enrolment","ALL","18 Years",{"count":81,"type":82},5,"ESTIMATED","OBSERVATIONAL","Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel technique which allows for identification of which cells are present and what they are doing. This hopes to better understand radiation pneumonitis, a dose-limiting toxicity in cancer treatment which can be highly morbid and even fatal.",[86],"Radiation Pneumonitis",[88,89,90],"radiation pneumonitis","cancer","single cell sequencing","2026-01-08",{"date":93,"type":94},"2026-01-09","ACTUAL",{"date":96,"type":94},"2024-10-25",{"date":98,"type":82},"2026-12",{"name":5,"class":6},3]