[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618626":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":29,"responsibleParty":49,"collaborators":25,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":25,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":25,"enrollmentInfo":61,"targetDuration":25,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":25,"overallStatus":72,"whyStopped":25,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"The Dental Hospital of Zhejiang University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","ACTIVE_COMPARATOR","Tooth extraction in the aesthetic area of the anterior teeth with the expansion and flap were reduced in the operative area. Site preservation surgery was performed using Bio-oss (0.5g, Small granule) and bio-gide (25\\*25mm size) . The gums were closely drawn and sutured.",[13],"Procedure: site preservation surgery with close sutures",{"label":15,"type":16,"description":17,"interventionNames":18},"Experimental group","EXPERIMENTAL","Tooth extraction in the aesthetic area of the anterior teeth without the expansion and flap were reduced in the operative area. Site preservation surgery was perfomed using Bio-oss (0.5g, Small granule) and Yinlife PCL membrane (25\\*25mm size) , with opened wound.",[19],"Procedure: site preservation surgery with open healing",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"PROCEDURE","site preservation surgery with open healing",[15],null,{"type":22,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"site preservation surgery with close sutures",[9],[30],{"facility":31,"status":25,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Stomatology Hospital, Zhejiang University School of Medicine","Hangzhou","Zhejiang","310000","China","CN",{"type":38,"coordinates":39},"Point",[40,41],120.16142,30.29365,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":25,"email":48},"Jue Shi, Doctor","CONTACT","+86 13757171359","dentistsj@zju.edu.cn",{"type":50,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100618626","site-preservation-was-performed-through-an-open-healing-oral-restorative-membrane-100618626",false,"NCT07334067","Site Preservation Was Performed Through an Open Healing Oral Restorative Membrane","The Application and Efficacy of Dental Prosthesis Membrane in the Preservation of Anterior Esthetic Area After Tooth Extraction","Inclusion Criteria:\n\n* 1: Age ≥18 years old\n\n  2: The affected teeth did not have the conditions for immediate implant placement: thin gingival biotype, labial bone plate thickness \\\u003C1 mm, the labial bone plate was missing, the distance between the labial bone plate crest and the cemento-enamel junction\\>3 mm\n\n  3: No systemic diseases and good oral hygiene\n\n  4: Be willing to receive treatment and regular follow-up and review, and signed the informed consent\n\nExclusion Criteria:\n\n* 1: Uncontrolled systemic diseases, such as heart, liver and kidney diseases, systemic infections, diabetes, etc\n\n  2: Women who are pregnant or lactating\n\n  3: Taking bisphosphonates, glucocorticoids and other drugs that affect bone metabolism for a long time or within 5 years\n\n  4: Patients receiving oral and maxillofacial radiotherapy in the past five years\n\n  5: Patients suffering uncontrolled periodontal disease",true,"ALL","18 Years",{"count":62,"type":63},40,"ESTIMATED","INTERVENTIONAL",[66],"NA","In this study, an open healing oral restoration membrane was used for site preservation in the esthetic area after tooth extraction to maintain the space for tooth extraction and bone formation. Clinical observation and cone-beam computed tomography (CBCT) were used to comprehensively evaluate the effect of this operation on promoting the growth of soft and hard tissues, and to provide a new treatment method for site preservation in the esthetic area of clinical anterior teeth.",[69,70,71],"Site Preservation","Soft Tissue Healing","Anterior Dental Aesthetic Area","NOT_YET_RECRUITING","2025-12-30",{"date":75,"type":76},"2026-01-12","ACTUAL",{"date":78,"type":63},"2025-12-15",{"date":80,"type":63},"2026-12-30",{"name":5,"class":6},1]