[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568171":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":55,"collaborators":20,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":20,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":20,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":20,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Manitoba","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Eccentric Exercise","EXPERIMENTAL","300 repetitions of isokinetic dynamometer eccentric knee extensions.",[13],"Procedure: Eccentric resistance-exercise",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Eccentric resistance-exercise","Each participant will complete 300 repetitions of eccentric knee extensions using an isokinetic dynamometer after a baseline skeletal muscle biopsy is taken. Three hours following this, a second muscle biopsy will be taken to evaluate the changes in the dependent variables being measured (myokines).",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Stephen M Cornish, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","204-381-7296","Stephen.Cornish@umanitoba.ca",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Applied Research Centre, Faculty of Kinesiology, University of Manitoba","RECRUITING","Winnipeg","Manitoba","R3T2N2","Canada","CA",{"type":40,"coordinates":41},"Point",[42,43],-97.14704,49.8844,{"lat":43,"lon":42},[46,50,54],{"name":47,"role":27,"phone":48,"phoneExt":20,"email":49},"Stephen M Cornish, Ph.D.","204-474-9981","Stephen.Cornish@umnaitoba.ca",{"name":51,"role":27,"phone":52,"phoneExt":20,"email":53},"Zach Henderson, M.Sc.","204-474-7858","zachariah.henderson@umanitoba.ca",{"name":47,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":56,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100568171","skeletal-muscle-myokine-response-to-acute-eccentric-exercise-100568171",false,"NCT06677749","Skeletal Muscle Myokine Response to Acute Eccentric Exercise","Inclusion Criteria:\n\n* 18-35 years old\n* healthy\n* recreationally active (\\>\u002F= 150 minutes of moderate to vigorous physical activity per week for at least the past three months)\n\nExclusion Criteria:\n\n* \"yes\" answer to the Get Active Questionnaire which screens for health conditions that may affect exercise ability",true,"ALL","18 Years","35 Years",{"count":68,"type":69},12,"ESTIMATED","INTERVENTIONAL",[72],"NA","The purpose of this study is to evaluate the acute local skeletal muscle inflammatory response to thigh muscle (quadriceps) eccentric muscle actions. Eccentric muscle actions occur when the muscle is lengthening as it contracts. This is a pilot project to assess the degree of inflammatory biomarkers, called myokines, that are released locally in skeletal muscle tissue after an acute bout of resistance-exercise using a resistance-exercise machine called an isokinetic dynamometer.",[75],"Skeletal Muscle","2024-11-04",{"date":78,"type":79},"2024-11-07","ACTUAL",{"date":81,"type":69},"2024-11-15",{"date":83,"type":69},"2025-11-01",{"name":5,"class":6},1]