[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520117":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Sleep and Circadian Rhythms biomarker cohort",null,"Cohort will complete a series of blood sample donations (both intraoperatively and postoperatively) as well as complete daily neurocognitive assessments at baseline and on PODs 1 - 3.",[13],{"name":14,"affiliation":5,"role":15},"Lei Gao, MBBS","PRINCIPAL_INVESTIGATOR",[17,21],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","(617)888-2941","lgao@mgh.harvard.edu",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Elizabeth Gleeson, BS","(650)704-6458","egleeson1@mgh.harvard.edu",[26],{"facility":5,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-71.05977,42.35843,{"lat":37,"lon":36},[40,43],{"name":41,"role":18,"phone":42,"phoneExt":10,"email":20},"Lei Gao, MD","6178882941",{"name":44,"role":18,"phone":45,"phoneExt":10,"email":46},"Elizabeth Sugg, BA","6177246700","esugg@mgh.harvard.edu",{"type":15,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Lei Gao, MBBS, MMSc","Attending Physician, Department of Anesthesia, Critical Care, and Pain Medicine","100520117","sleep-and-circadian-rhythm-biomarkers-of-postoperative-delirium-100520117",false,"NCT06052397","Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium","SLEEP-POD","Inclusion Criteria:\n\n* Age \\>= 70 years old\n* Scheduled to undergo major orthopedic surgery\n* Expected postoperative recovery of more than 24 hours as an inpatient\n\nExclusion Criteria:\n\n* Cognitive impairment leading to inability to consent\n* Patients with limited mobility or inability to wear an actigraphy watch\n* Patients with infection at the site of actigraphy watch, allergies to materials of watch\n* Patients with \\> two days in the ICU during the month prior to surgery\n* Renal or liver failure\n* Severe neurocognitive damage or history of psychiatric illness\n* Blindness or deafness\n* Patients who are non-English speaking","ALL","70 Years",{"count":60,"type":61},150,"ESTIMATED","OBSERVATIONAL","The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are:\n\n1. To define sleep\u002Fcircadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study.\n2. To determine if plasma Alzheimer's disease (AD) pathology\u002Finflammatory burden interacts with or moderates the relationship between a sleep\u002Fcircadian biomarker and post-operative delirium (POD) risk.\n3. To determine whether sleep\u002Fcircadian regulation interacts with the genetic risk of AD to influence POD\u002Fcognitive decline.\n\nParticipants will be asked to:\n\n1. Donate several blood samples both intraoperatively and postoperatively\n2. Complete baseline and postoperative neurocognitive assessments\n3. Wear an actigraphy data collection watch for the two weeks prior to their surgery",[65,66,67],"Delirium, Postoperative","Cognitive Decline","Dementia",[69,70,71,72,67],"Sleep","Postoperative Delirium","Circadian Rhythms","Cognition","2026-02-09",{"date":75,"type":76},"2026-02-11","ACTUAL",{"date":78,"type":76},"2023-09-12",{"date":80,"type":61},"2027-09-30",{"name":5,"class":6},1]