[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100350228":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":24,"responsibleParty":45,"collaborators":18,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":18,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":18,"overallStatus":27,"whyStopped":18,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"University of Massachusetts, Amherst","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sleep","EXPERIMENTAL","Individuals will either nap (Exps 1, 4) or have overnight sleep (Exps 2, 3, 5, 6)",[13],"Behavioral: Sleep",{"label":15,"type":16,"description":17,"interventionNames":18},"Wake","NO_INTERVENTION","Individuals will stay awake for the same amount of time as they slept in the sleep condition",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","Participants will sleep (either a mid-day nap or normal overnight sleep)",[9],[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"University of Massachusetts","RECRUITING","Amherst","Massachusetts","01003","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-72.51852,42.36723,{"lat":37,"lon":36},[40],{"name":41,"role":42,"phone":43,"phoneExt":18,"email":44},"Mary Emma Searles","CONTACT","413-545-4831","msearles@umass.edu",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Rebecca Spencer","Professor","100350228","sleep-dependent-learning-in-aging-100350228",false,"NCT03840083","Sleep-dependent Learning in Aging","What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging","Inclusion Criteria:\n\n* Age 18-80 yrs\n* Healthy sleeper\n* No diagnosed sleep or neurodegenerative disorder\n\nExclusion Criteria:\n\n1. Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \\>15; a Period-Limb Movement in Sleep index of \\>15\u002Fhr; sleep-onset latency \\> 45 min (indicative of insomnia); or sleep efficiency \\\u003C 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.\n2. Past diagnosis neurological illness or head injury\n3. Reported average sleep per night \\\u003C 5 or \\> 9 hrs\n4. Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing\n5. Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)\n6. Daily caffeine intake of \\> 4 cups (coffee, tea, colas)\n7. Weekly alcohol intake of \\> 10 cups\n8. Pregnancy or \\\u003C 12 months post-partum\n9. History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \\> 25\n10. Abnormal sleep (e.g., shift work, travel across \\>2 time zones within the past 3 months).\n11. Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);\n12. Score indicative of cognitive dysfunction (subtest scores \\\u003C 40)\n13. Beck Depression Scale score indicative of depression (\\> 19).\n\nAdditionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for:\n\n1. Left handed or ambidextrous\n2. Claustrophobia\n3. Presence of metal (thoroughly screened via questionnaire and metal detector)\n4. Pregnancy",true,"ALL","18 Years","80 Years",{"count":61,"type":62},584,"ESTIMATED","INTERVENTIONAL",[65],"NA","The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.",[9],"2025-03-30",{"date":70,"type":71},"2025-04-03","ACTUAL",{"date":73,"type":71},"2018-07-15",{"date":75,"type":62},"2025-07-15",{"name":5,"class":6},1]