[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570789":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":18,"responsibleParty":33,"collaborators":35,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":7,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":7,"enrollmentInfo":50,"targetDuration":7,"studyType":53,"phases":7,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":65,"whyStopped":7,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"International Research Training Group 2804","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Christian Benedict, PhD","CONTACT","+46 18 471 43 30","christian.benedict@farmbio.uu.se",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Nina Goll, M. Sc.","+49170 29 88918","nina.goll@uni-tuebingen.de",[19],{"facility":20,"status":7,"city":21,"state":22,"zip":23,"country":22,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"University of Uppsala","Uppsala","Sweden","751 24","SE",{"type":26,"coordinates":27},"Point",[28,29],17.63889,59.85882,{"lat":29,"lon":28},[32],{"name":10,"role":11,"phone":7,"phoneExt":7,"email":7},{"type":34,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[36,38],{"name":37,"class":6},"Uppsala University",{"name":39,"class":6},"Uppsala University Hospital","100570789","sleep-oxytocin-and-reward-processing-in-women-in-the-postpartum-phase-100570789",false,"NCT06711809","Sleep, Oxytocin and Reward Processing in Women in the Postpartum Phase","The Role of Sleep, Oxytocin and Reward Processing in Women in the Postpartum Phase","Inclusion Criteria:\n\n* Age: 18-40\n* Biological sex\u002Fgender: female\n* Swedish\u002FEnglish fluency\n* Postpartum phase: 6 weeks to 1 year\n\nExclusion Criteria:\n\n* Age \\\u003C 18\n* Neonatal complications",true,"FEMALE","18 Years",{"count":51,"type":52},100,"ESTIMATED","OBSERVATIONAL","During and after pregnancy, a woman's body and brain undergo significant changes that help her adapt to caregiving and emotional needs. However, this period also makes women more susceptible to emotional disorders, such as peripartum depression (PPD), which affects about 10-15% of new mothers. PPD can negatively impact both the mother and her baby, disrupting mood, motivation, and mothering abilities. Hormonal changes and poor sleep are some of the risk factors that might worsen these depressive symptoms.\n\nTraditionally, sleep studies on PPD have relied on questionnaires and short-term sleep assessments. With the advent of smartwatches and digital devices, we can now monitor sleep in a home environment over longer periods. Oxytocin, a hormone crucial for childbirth, breastfeeding, and bonding with the baby, is thought to play a role in PPD. Studies suggest that higher levels of oxytocin might be linked to lower levels of postpartum depression, though findings are not always consistent. Oxytocin also affects sleep and is connected to brain areas that regulate reward and motivation.\n\nThis study aims to explore the relationship between sleep, oxytocin, and reward processing in new mothers. The investigators will include women with varying levels of depressive symptoms and use home-based sleep assessments to gather data. Our goal is to better understand how these factors interact in the postpartum period and how they might influence a mother's mental health and caregiving abilities.\n\nThe investigators expect that oxytocin levels are reduced in women with higher depressive symptoms and that these reductions are associated with sleep impairments, breastfeeding and altered reward processing.",[56],"Postpartum Depression",[58,59,60,61,62,63,64],"oxytocin","peripartum depression","postpartum depression","sleep","sleep assessment","reward processing","motivation","NOT_YET_RECRUITING","2024-11-27",{"date":68,"type":69},"2024-12-02","ACTUAL",{"date":71,"type":52},"2025-01-01",{"date":73,"type":52},"2026-12-31",{"name":5,"class":6},1]