[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632690":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":155,"collaborators":19,"id":157,"slug":158,"hasResults":159,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":19,"eligibilityCriteria":163,"healthyVolunteers":159,"sex":164,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":19,"studyType":170,"phases":171,"briefSummary":173,"conditions":174,"keywords":19,"overallStatus":63,"whyStopped":19,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":188},{"fullName":5,"class":6},"Meyer Children's Hospital IRCCS","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Pediatric and adult patients with podocytopathies","EXPERIMENTAL","Participants are not assigned to therapeutic interventions. Serum and renal biopsy samples obtained during routine clinical care are collected and analyzed for research purposes, including ELISA testing for anti-nephrin antibodies, others anti-slit antibodies and advanced microscopy evaluation.",[13],"Other: Serum and renal tissue analysis",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Serum and renal tissue analysis","Analysis of serum and renal biopsy material collected as part of routine clinical care. Laboratory procedures include ELISA assays for the detection of anti-nephrin and\u002For others anti-slit antibodies and advanced imaging techniques, such as high-resolution confocal microscopy and STED microscopy, performed for research purposes",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Paola Romagnani, MD, PhD","CONTACT","+39 0555662563","paola.romagnani@meyer.it",[27,41,51,62,77,85,90,95,103,111,119,127,135,145],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":19},"Mayo Clinic","NOT_YET_RECRUITING","Rochester","Minnesota","55902","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-92.4699,44.02163,{"lat":39,"lon":38},{"facility":42,"status":29,"city":43,"state":19,"zip":19,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":50,"contacts":19},"Ludwig-Maximilians Universitat","München","Germany","DE",{"type":36,"coordinates":47},[48,49],13.31243,51.60698,{"lat":49,"lon":48},{"facility":52,"status":29,"city":53,"state":54,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":61,"contacts":19},"Ospedale Santa Maria Annunziata","Bagno a Ripoli","Firenze","Italy","IT",{"type":36,"coordinates":58},[59,60],11.32252,43.75115,{"lat":60,"lon":59},{"facility":5,"status":63,"city":64,"state":65,"zip":66,"country":55,"countryCode":56,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"RECRUITING","Florence","FIRENZE","50139",{"type":36,"coordinates":68},[69,70],11.24626,43.77925,{"lat":70,"lon":69},[73,74],{"name":22,"role":23,"phone":19,"phoneExt":24,"email":25},{"name":75,"role":23,"phone":19,"phoneExt":19,"email":76},"Valentina Raglianti, MD","valentina.raglianti@meyer.it",{"facility":78,"status":29,"city":79,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":80,"geoPoint":84,"contacts":19},"IRCCS Azienda Ospedaliero - Universitaria","Bologna",{"type":36,"coordinates":81},[82,83],11.33875,44.49381,{"lat":83,"lon":82},{"facility":86,"status":29,"city":64,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":87,"geoPoint":89,"contacts":19},"Azienda Ospedaliero Universitaria Careggi",{"type":36,"coordinates":88},[69,70],{"lat":70,"lon":69},{"facility":91,"status":29,"city":64,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":92,"geoPoint":94,"contacts":19},"Ospedale S. Giovanni di Dio",{"type":36,"coordinates":93},[69,70],{"lat":70,"lon":69},{"facility":96,"status":29,"city":97,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":98,"geoPoint":102,"contacts":19},"IRCCS Istituto Giannina Gaslini","Genova",{"type":36,"coordinates":99},[100,101],11.87211,45.21604,{"lat":101,"lon":100},{"facility":104,"status":29,"city":105,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":106,"geoPoint":110,"contacts":19},"Azienda Ospedaliero-Universitaria di Parma","Parma",{"type":36,"coordinates":107},[108,109],10.32618,44.79935,{"lat":109,"lon":108},{"facility":112,"status":29,"city":113,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":114,"geoPoint":118,"contacts":19},"Azienda Ospedaliero Universitaria Pisana","Pisa",{"type":36,"coordinates":115},[116,117],10.4036,43.70853,{"lat":117,"lon":116},{"facility":120,"status":29,"city":121,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":122,"geoPoint":126,"contacts":19},"Ospedale Santo Stefano","Prato",{"type":36,"coordinates":123},[124,125],11.09699,43.8805,{"lat":125,"lon":124},{"facility":128,"status":29,"city":129,"state":19,"zip":19,"country":55,"countryCode":56,"cosmosGeoPoint":130,"geoPoint":134,"contacts":19},"Azienda USL - IRCCS","Reggio Emilia",{"type":36,"coordinates":131},[132,133],10.63125,44.69825,{"lat":133,"lon":132},{"facility":136,"status":29,"city":137,"state":19,"zip":19,"country":138,"countryCode":139,"cosmosGeoPoint":140,"geoPoint":144,"contacts":19},"Hospital General de México, Mexico City","Mexico City","Mexico","MX",{"type":36,"coordinates":141},[142,143],-99.12766,19.42847,{"lat":143,"lon":142},{"facility":146,"status":29,"city":147,"state":19,"zip":19,"country":148,"countryCode":149,"cosmosGeoPoint":150,"geoPoint":154,"contacts":19},"Bellvitge University Hospital","Barcelona","Spain","ES",{"type":36,"coordinates":151},[152,153],2.15899,41.38879,{"lat":153,"lon":152},{"type":156,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100632690","slit-abs-study-on-patients-with-autoimmune-podocytopathy-100632690",false,"NCT07516964","SLIT ABS: Study on Patients With Autoimmune Podocytopathy","Validation and Implementation of Diagnostic Techniques for the Detection of Circulating Factors in Patients With Autoimmune Podocytopathy","Inclusion Criteria:\n\n* Pediatric and adult patients with a diagnosis of podocytopathy\n* Patients with nephrotic syndrome and\u002For histological diagnosis of minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), collapsing glomerulopathy (CG), or diffuse mesangial sclerosis (DMS)\n* Both newly diagnosed (incident) patients and patients already under follow-up at participating centers\n* Availability of clinical data from medical records (including paper and\u002For electronic records, laboratory reports, and discharge summaries)\n* Availability of biological samples (e.g., blood and\u002For renal biopsy), if collected as part of routine clinical care\n* Signed informed consent by the patient or legal guardian (and assent when applicable)\n\nExclusion Criteria:\n\n* Refusal or inability of the patient, parents, or legal guardian to provide informed consent\n* Lack of sufficient clinical data or unavailable biological samples required for the study","ALL","0 Years","99 Years",{"count":168,"type":169},50,"ESTIMATED","INTERVENTIONAL",[172],"NA","Nephrotic syndrome is a kidney condition that mainly affects children and is characterized by high levels of protein in the urine, low levels of protein in the blood, and swelling. While many children respond well to steroid treatment, a large proportion experience relapses or become dependent on therapy. In some cases, the disease does not respond to standard treatments and may progress to chronic kidney disease.\n\nRecent research suggests that, in addition to genetic factors, immune system mechanisms may play a key role in the development and progression of nephrotic syndrome. In particular, some patients produce autoantibodies against nephrin, an essential protein of the kidney filtration barrier. These autoantibodies may be associated with disease activity and treatment response.\n\nThe aim of this study is to investigate the presence of anti-nephrin autoantibodies in children with nephrotic syndrome and to better understand their role in disease mechanisms and clinical outcomes.The study will also explore the presence of other autoantibodies targeting components of the glomerular filtration barrier. The study will use advanced laboratory techniques, including blood tests and detailed analysis of kidney biopsy samples, to identify these antibodies and their relationship with kidney structure and function.\n\nBy integrating laboratory findings with clinical data, this study aims to improve the understanding of nephrotic syndrome and support the development of more personalized diagnostic and therapeutic strategies, with the goal of improving patient outcomes and reducing unnecessary or ineffective treatments.",[175,176,177,178],"Nephrotic Syndrome With Edema (Diagnosis)","Minimal Change Nephrotic Syndrome","Focal Segmental Glomerulosclerosis (FSGS)","Nephrotic Syndrome Due to Idiopathic Membranous Nephropathy","2026-04-01",{"date":181,"type":182},"2026-04-08","ACTUAL",{"date":184,"type":182},"2025-06-10",{"date":186,"type":169},"2036-10",{"name":5,"class":6},14]