[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629285":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":18,"responsibleParty":34,"collaborators":7,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":7,"enrollmentInfo":46,"targetDuration":7,"studyType":49,"phases":7,"briefSummary":50,"conditions":51,"keywords":57,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Xavier DRAY, MD PhD","CONTACT","+33 (0) 1 49 28 21 61","xavier.dray@aphp.fr",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Aymeric BECQ, MD","+33 (0) 1 49 81 23 55","aymeric.becq@aphp.fr",[19],{"facility":20,"status":21,"city":22,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Center for Digestive Endoscopy, Saint-Antoine Hospital","RECRUITING","Paris","France","FR",{"type":26,"coordinates":27},"Point",[28,29],2.3488,48.85341,{"lat":29,"lon":28},[32],{"name":33,"role":11,"phone":12,"phoneExt":7,"email":13},"Xavier DRAY, MD, PhD",{"type":35,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100629285","small-bowel-capsule-endoscopy-in-lynch-syndrome-100629285",false,"NCT07472686","Small Bowel Capsule Endoscopy in Lynch Syndrome","Small Bowel Capsule Endoscopy for (Pre)Neoplastic Lesion Screening in Patients With Lynch Syndrome","iCARE4Lynch","Inclusion Criteria:\n\n* Patient carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM)\n* Capsule endoscopy screening for (pre)neoplastic lesions of the small intestine\n* No opposition to the reuse of healthcare data for research purposes\n\nExclusion Criteria:\n\n* Absence of documented MMR gene variant\n* Opposition to the study","ALL","18 Years",{"count":47,"type":48},400,"ESTIMATED","OBSERVATIONAL","The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown.\n\nThe iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.",[52,53,54,55,56],"MMR Mutation","Small Bowel Adenoma","Small-bowel Adenocarcinoma","Lynch Syndrome","Cancer",[56,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72],"Lynch syndrome","Capsule endoscopy","Screening","Small bowel","Small-bowel adenoma","Small-bowel adenocarcinoma","Small-bowel cancer","Small-bowel capsule endoscopy","pathogenic variant","DNA mismatch repair gene (MMR)","MLH1","MSH2","MSH6","PMS2","EPCAM","2026-03-11",{"date":75,"type":76},"2026-03-16","ACTUAL",{"date":78,"type":76},"2025-06-16",{"date":80,"type":48},"2026-12",{"name":5,"class":6},1]