[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592160":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":24,"centralContacts":28,"locations":35,"responsibleParty":79,"collaborators":82,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":33,"enrollmentInfo":96,"targetDuration":33,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":108,"overallStatus":61,"whyStopped":33,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Erasmus Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Lynch-carriers with a (colorectal) tumor","EXPERIMENTAL","People with a newly diagnosed Lynch-associated tumor will be asked to undergo an extra blood test.",[13],"Diagnostic Test: Blood Product",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","Blood Product","An (extra) blood test will be done on participants. This will be analyzed for circulating tumor DNA (ctDNA) via a multi-omics approach.",[9],[21,22,23],"Blood test","Blood draw","Liquid biopsy",[25],{"name":26,"affiliation":5,"role":27},"Anja Wagner, Dr.","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Lotte van Leeuwen, BSc","CONTACT","+31646245198",null,"l.vanleeuwen@erasmusmc.nl",[36,59],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Leiden University Medical Center","NOT_YET_RECRUITING","Leiden","South Holland","2333ZG","Netherlands","NL",{"type":45,"coordinates":46},"Point",[47,48],4.49306,52.15833,{"lat":48,"lon":47},[51,55,57],{"name":52,"role":31,"phone":53,"phoneExt":33,"email":54},"Maartje Nielsen, Dr.","+31624240843","m.nielsen@lumc.nl",{"name":56,"role":27,"phone":33,"phoneExt":33,"email":33},"Monique van Leerdam, Prof.dr.",{"name":52,"role":58,"phone":33,"phoneExt":33,"email":33},"SUB_INVESTIGATOR",{"facility":60,"status":61,"city":62,"state":40,"zip":63,"country":42,"countryCode":43,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Erasmus MC","RECRUITING","Rotterdam","3015GD",{"type":45,"coordinates":65},[66,67],4.47917,51.9225,{"lat":67,"lon":66},[70,72,73,75,77],{"name":30,"role":31,"phone":71,"phoneExt":33,"email":34},"0646245198",{"name":26,"role":27,"phone":33,"phoneExt":33,"email":33},{"name":74,"role":58,"phone":33,"phoneExt":33,"email":33},"Saskia Wilting, Dr.",{"name":76,"role":58,"phone":33,"phoneExt":33,"email":33},"Lotte van Leeuwen, BSc.",{"name":78,"role":58,"phone":33,"phoneExt":33,"email":33},"Manon Spaander, Dr.",{"type":27,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Lotte van Leeuwen","PhD Candidate",[83,85],{"name":84,"class":6},"Dutch Cancer Society",{"name":37,"class":6},"100592160","smart-measurement-of-circulating-tumor-dna-100592160",false,"NCT06989814","Smart Measurement of Circulating Tumor DNA","Smart Measurement of Circulating Tumor DNA: a Tumor-agnostic Computational Tool to Improve Colorectal Cancer Care","SMART","Inclusion Criteria:\n\n(suspect) Lynch Syndrome carriers who:\n\n* Have proven Lynch Syndrome (MMR-gene or EPCAM mutation), or have a proven microsatellite instability high (MSI-H)tumor;\n* Are at least 18 years old; Have been diagnosed with any form of cancer at the time of inclusion, but have had no treatment yet;\n* Have granted informed consent to participate in this study.\n\nExclusion Criteria:\n\n(suspect) Lynch Syndrome carriers who:\n\n* Are unwilling to undergo extra blood sampling;\n* Are under the age of 18;\n* Have no newly diagnosed tumors at time of inclusion;\n* Have been treated for their tumor at time of inclusion;\n* Are not able to read or understand Dutch language or are mentally not capable.","ALL","18 Years",{"count":97,"type":98},50,"ESTIMATED","INTERVENTIONAL",[101],"NA","The goal of this study is to develop a blood-test which can detect colorectal cancer in early stages.\n\nParticipants will be asked to take an extra blood test, which will be analyzed further in the lab.",[104,105,106,107],"Colorectal Neoplasms","Colorectal Neoplasms Malignant","Colorectal Neoplasms, Hereditary Nonpolyposis","Hereditary Nonpolyposis Colon Cancer",[109,110,111,112,113,114],"Liquid Biopsy","Colorectal cancer","Early detection","Prevention","Surveillance","Screening","2025-08-05",{"date":117,"type":118},"2025-08-11","ACTUAL",{"date":120,"type":118},"2025-05-16",{"date":122,"type":98},"2027-02-01",{"name":5,"class":6},2]