[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577744":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":34,"locations":39,"responsibleParty":59,"collaborators":61,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":23,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":23,"enrollmentInfo":76,"targetDuration":23,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":42,"whyStopped":23,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High Cysteine Diet","ACTIVE_COMPARATOR","A dietary pattern designed to have a high level of dietary cysteine",[13],"Other: High Cysteine Diet",{"label":15,"type":6,"description":16,"interventionNames":17},"Low Cysteine Diet","A dietary pattern designed to have a low level of dietary cysteine",[18],"Other: Low Cysteine Diet",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"A healthy diet pattern which contains high levels of cysteine or cysteine-related compounds. The high and low cysteine diets will be designed by a research dietician to differ primarily in their concentration of cysteine while providing similar levels of calories, protein, fats, carbohydrates, fiber, and several micronutrients. No additional supplementation of cysteine will be used. Examples of high cysteine foods: chicken, eggs, lentils, yogurt, garlic, cheese, soybeans",[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"A healthy diet pattern which contains low levels of cysteine or cysteine-related compounds. The high and low cysteine diets will be designed by a research dietician to differ primarily in their concentration of cysteine while providing similar levels of calories, protein, fats, carbohydrates, fiber, and several micronutrients. The low cysteine diet includes lower-protein food sources. Examples of low cysteine foods: rice, bread, oranges, bananas, lettuce, snow peas, peppers",[15],[28,31],{"name":29,"affiliation":5,"role":30},"Noel T Mueller, PhD","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":33,"role":30},"Andrew B Hall, PhD","University of Maryland, College Park",[35],{"name":29,"role":36,"phone":37,"phoneExt":23,"email":38},"CONTACT","414-779-1167","noel.mueller@cuanschutz.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of Colorado Anschutz Medical Campus","RECRUITING","Aurora","Colorado","80045","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-104.83192,39.72943,{"lat":52,"lon":51},[55],{"name":56,"role":36,"phone":57,"phoneExt":23,"email":58},"Devin Grove, BS","303-724-1179","devin.grove@cuanschutz.edu",{"type":60,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[62,65],{"name":63,"class":64},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH",{"name":33,"class":6},"100577744","smart-underwear-to-measure-diet-induced-hydrogen-sulfide-production-100577744",false,"NCT06802276","Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production","Employing Smart Underwear to Measure Gut Microbial Hydrogen Sulfide Production","The inclusion\u002Fexclusion criteria will identify generally healthy volunteers that are able to ingest the intervention diets. Exclusion criteria based on diseases, medications, allergies, and specific dietary requirements will minimize the risks of adverse reactions to the intervention diets.\n\nInclusion Criteria:\n\n* Generally healthy volunteers defined as having no major known health conditions (e.g., diabetes, cancer, hypertension, etc.).\n* Normal bowel movements, with approximately 1 bowel movement reported per day\n* Willing to discuss flatus\n* Ages \\>18yrs\n* Willing to complete the entire study protocol, i.e. eating all of the food that is provided and completing all required measurements.\n\nExclusion Criteria:\n\n* Self-report or other evidence of diabetes, other endocrine\u002Fmetabolic abnormality, dyslipidemia, morbid obesity, severe hypertension, chronic kidney disease, liver disease, pulmonary disease, gastrointestinal, and cardiovascular diseases\n* Chronic medications for any of the above conditions\n* Food allergy that interferes with ability to complete the study\n* Food preferences, intolerance, or dietary requirements that would interfere with diet adherence\n* Planned dietary changes during the study period\n* Lack of appropriate food refrigeration and preparation equipment (e.g.- oven or microwave)\n* Pregnancy or planned pregnancy in the next month\n* Physical measurements: BMI \\> 35 kg\u002Fm2",true,"ALL","18 Years",{"count":77,"type":78},25,"ESTIMATED","INTERVENTIONAL",[81],"NA","The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production. The core design is a single-site, 2-period, crossover feeding study with 6-day diet periods and an approximately 11-day washout period. Participants are fed each of two isocaloric diets designed to contrast gut microbial H₂S production (i.e., a high cysteine vs. low cysteine diet), in a random order.",[84,85],"Hydrogen Sulfide","Gastrointestinal Microbiome",[84,87,88,89,90],"H2S","Diet","Cysteine","Gut Microbiome","2026-04-27",{"date":93,"type":94},"2026-04-29","ACTUAL",{"date":96,"type":94},"2025-05-21",{"date":98,"type":78},"2027-06-30",{"name":5,"class":6},1]