[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100469071":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":52,"collaborators":55,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":18,"enrollmentInfo":68,"targetDuration":18,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":18,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Tulane University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"sodium reduction intervention","EXPERIMENTAL","The sodium reduction intervention is a dietician-led behavioral intervention consisting of two phases, first a 3-month intensive intervention phase, followed by a 9-month maintenance phase. The overall goal of the intervention is to reduce sodium intake to \\\u003C2,300 mg per day based on the most recent guideline from the National Academies of Medicine. Both phases will include individual and group behavioral modification counseling designed to facilitate a reduction in dietary sodium intake.",[13],"Behavioral: Sodium Reduction Intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Diet","NO_INTERVENTION","Participants randomized to the usual diet group will receive standard care from their providers with no study intervention.",null,[20],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","Sodium Reduction Intervention",[9],[25],{"name":26,"affiliation":5,"role":27},"Katherine T Mills, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Marigny Bostock, MA, CHES","CONTACT","504-988-4391","mbostock@tulane.edu",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Tulane University Office of Health Research","RECRUITING","New Orleans","Louisiana","70112","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-90.07507,29.95465,{"lat":47,"lon":46},[50],{"name":51,"role":31,"phone":32,"phoneExt":18,"email":33},"Marigny J Bostock, MA, CHES",{"type":27,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Katherine T Mills","Associate Professor",[56],{"name":57,"class":6},"Johns Hopkins University","100469071","sodium-lowering-vascular-effects-trial-100469071",false,"NCT05388032","Sodium Lowering Vascular Effects Trial","A Mechanistic Trial of Dietary Sodium Reduction on Vascular Structure and Function","SOLVE","Inclusion Criteria:\n\n* Men or women aged ≥40 years. Individuals \\\u003C40 years are at a low risk for clinical and subclinical CVD\n* Elevated BP or hypertension (systolic BP ≥120 mmHg and diastolic BP ≥80 mmHg with or without use of antihypertensive medications)\n\nExclusion Criteria:\n\n* Glomerular filtration rate (eGFR) \\\u003C30 or end-stage renal disease (kidney transplant or chronic dialysis)\n* History of cardiovascular disease\n* Shift worker or regularly work at night\n* Cancer requiring chemotherapy or radiation treatment in the previous two years\n* Current pregnancy or breastfeeding or plans to become pregnant during the study\n* Consumption of ≥21 alcoholic drinks\u002Fweek\n* Current participation in another lifestyle intervention or drug trial\n* Current residence or planned residence that makes it difficult to meet trial requirements\n* Other concerns regarding ability to meet trial requirements (at the discretion of the study coordinator)","ALL","40 Years",{"count":69,"type":70},256,"ESTIMATED","INTERVENTIONAL",[73],"NA","The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.",[76,77,78,79],"Endothelial Dysfunction","Vascular Stiffness","Left Ventricular Hypertrophy","Left Ventricular Dysfunction","2024-11-20",{"date":82,"type":83},"2024-11-22","ACTUAL",{"date":85,"type":83},"2023-01-25",{"date":87,"type":70},"2026-12-31",{"name":5,"class":6},1]