[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593699":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":29,"responsibleParty":48,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Imperial College London","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Derivation",null,"These patients will undergo the research protocol. In these patients, the investigators will attempt to implant a permanent conduction system pacing lead, in lieu of the RV or LV lead. The lead will be implanted by operators who have implanted more than 40 leads to overcome the learning curve.",{"label":13,"type":10,"description":14,"interventionNames":10},"Validation","These patients will undergo a conduction system pacemaker as standard clinical practice. The implanters will prospectively apply the step-by-step algorithm derived above to implant the conduction system lead using standard equipment alone; fluoroscopy, PSA and 12-lead ECG. The investigators will assess the success rate, conduction system capture threshold, procedure time and fluoroscopy time. Although all operators will be highly experienced device implanters, these implants will include operators who are new to conduction system lead implantation.",{"label":16,"type":10,"description":17,"interventionNames":10},"2-lead ECG group","Patients with a chronic conduction system lead implant under device follow-up will under go 2-lead ECG of multiple pacing and sensing configurations. These patients will be attending for routine appointments. The pacing and sensing configurations are undertaken as part of routine checks.",[19],{"name":20,"affiliation":21,"role":22},"Whinnett, BM.BS","Imperial College London, Imperial College Healthcare Trust","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Akriti Naraen, MBChB","CONTACT","+91203-31-31000","a.naraen@imperial.ac.uk",[30],{"facility":31,"status":32,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Imperial College Healthcare Trust; Hammersmith Hospital","RECRUITING","London","W12 0HS","United Kingdom","UK",{"type":38,"coordinates":39},"Point",[40,41],-0.12574,51.50853,{"lat":41,"lon":40},[44,46],{"name":45,"role":26,"phone":10,"phoneExt":10,"email":28},"Akriti Naraen, MBCHb",{"name":47,"role":22,"phone":10,"phoneExt":10,"email":10},"Zachary Whinnett, BM.BS",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100593699","solutions-to-the-challenges-of-conduction-system-pacing-100593699",false,"NCT07009834","Solutions to the Challenges of Conduction System Pacing","CSA","Inclusion Criteria:\n\n1. Patients with a ventricular pacing indication: high grade atrioventricular block and symptomatic trifasicular, bifasicular block or left bundle branch block LBBB for cardiac resynchronisation therapy\n2. Adults willing to take part (ages 18 - 100 years old)\n3. Able to give consent.\n\nExclusion Criteria:\n\n1. Unable to give consent\n2. Children age \\\u003C 18 years and adults \\> 100 years old\n3. Pregnant patients As per standard of care, female patients of child-bearing age will have a urine pregnancy test prior to their procedure.","ALL","18 Years","100 Years",{"count":61,"type":62},300,"ESTIMATED","OBSERVATIONAL","Conduction system pacing is a new way of stimulating the heart using pacemaker wires. Traditional pacemakers stimulate the heart muscle which causes disordered heart beats: the walls of the heart move at different times. This wears down the heart over time.\n\nConduction system pacemakers stimulate the heart's electrical system directly producing natural heart beats that are much less disordered. Unfortunately, these pacemakers can only be implanted by a small group of experts at specialised centres with specialist equipment. This study aims to allow conduction system pacemakers to be offered to any patient at any hospital by simplifying the process of inserting the pacemaker wires and the improving the pacemaker's ability to interpret electrical traces.\n\nFirstly, the best locations in the heart for conduction system pacemaker wires using specialised electrical traces, MRI and ultrasound scans will be identified. Features that can be seen on X-ray to guide doctors to these locations will then be identified. Secondly, the investigators will collect electrical information from the pacemaker wires and additional electrical traces to develop an algorithm that can make the interpretation the electrical traces more accurate.",[66,67],"Conduction System Pacing","Pacing Therapy",[69,55],"Challenges of conduction system pacing","2025-07-09",{"date":72,"type":73},"2025-07-14","ACTUAL",{"date":75,"type":73},"2023-11-06",{"date":77,"type":62},"2026-11-06",{"name":5,"class":6},1]