[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490828":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":18,"locations":24,"responsibleParty":44,"collaborators":7,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":7,"enrollmentInfo":58,"targetDuration":7,"studyType":61,"phases":7,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":27,"whyStopped":7,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Isala","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Ultrasound of the diaphragm","Sonographic parameters of the diaphragm:\n\n* Thickening Fraction (TF); (Diaphragm thickness end-inspiration- Diaphragm thickness end-expiration) \u002F Diaphragm thickness end-expiration. (continuous variable).\n* Diaphragm end-expiratory thickness: Diaphragm thickness at end-expiration (continuous variable)\n* Diaphragm excursion (DE): diaphragm inspiratory amplitude during deep breathing (continuous variable).",[14],{"name":15,"affiliation":16,"role":17},"Marieke Duiverman, M.D. PhD.","University Medical Center Groningen","STUDY_DIRECTOR",[19],{"name":20,"role":21,"phone":22,"phoneExt":7,"email":23},"wytze s de Boer, m.d.","CONTACT","00316463120231","w.s.de.boer@isala.nl",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Isala Klinieken","RECRUITING","Zwolle","Overijssel","8025AB","Netherlands","NL",{"type":34,"coordinates":35},"Point",[36,37],6.09444,52.5125,{"lat":37,"lon":36},[40,43],{"name":41,"role":21,"phone":42,"phoneExt":7,"email":23},"Wytze de Boer, MD","+31646312031",{"name":41,"role":21,"phone":7,"phoneExt":7,"email":7},{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Wytze de Boer","Coördinating Investigator","100490828","sonographic-diaphragm-function-in-aecopd-100490828",false,"NCT05671198","Sonographic Diaphragm Function in AECOPD","Ultrasound of the Diaphragm As Physiological Biomarker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease","UNDATED","Inclusion Criteria:\n\n* Hospitalisation primarily because of severe acute exacerbation of COPD\n* COPD, according to GOLD 2018 definition\n* Post-bronchodilator FEV1\u002FFVC \\\u003C 0,70 and FEV1% \\\u003C 80%pred. within last 5 years\n\nExclusion Criteria:\n\n* Respiratory acidosis (pH \\\u003C 7.35 ánd PaCO2 \\> 6 kPA)\n* Need for (non-)invasive ventilation based on other criteria (e.g. severe hypoxia) upon presentation.\n* Established diagnosis of diaphragm diaphragm paralysis.\n* Inability for diaphragm imaging (e.g. mechanical ventilation, or unable to follow vocal instructions).\n* Those not able or unwilling to give written informed consent.\n* Pregnant women","ALL","18 Years",{"count":59,"type":60},51,"ESTIMATED","OBSERVATIONAL","The study will be conducted as a single-center, prospective cohort study. The primary objective of this study is to investigate the responsiveness of sonographic parameters of diaphragm to detect change in Borg score for dyspnea during hospitalisation for AECOPD without respiratory acidosis.",[64],"Copd",[66,67,68],"diaphragm","COPD","thoracic ultrasound","2024-10-02",{"date":71,"type":72},"2024-10-04","ACTUAL",{"date":74,"type":72},"2023-03-27",{"date":76,"type":60},"2025-08",{"name":5,"class":6},1]