[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520188":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":51,"locations":57,"responsibleParty":89,"collaborators":92,"id":96,"slug":97,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":55,"eligibilityCriteria":102,"healthyVolunteers":103,"sex":104,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":55,"studyType":110,"phases":111,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":60,"whyStopped":55,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"Emory University","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Young Able-Bodied individuals","ACTIVE_COMPARATOR","18-30 years old able-bodied individuals (healthy without any physical disability or neurological disorder).",[13,14],"Device: Prism adaptation therapy (PAT) + Electrical stimulation (E-stim)","Device: Prism adaptation therapy (PAT) + Sham Stimulator",{"label":16,"type":10,"description":17,"interventionNames":18},"Old Able-Bodied individuals","45-90 years old able-bodied individuals (healthy without any physical disability or neurological disorder).",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Stroke with Spatial Neglect (SN) individuals","EXPERIMENTAL","40-90 years individuals with more than 3 months following right hemisphere stroke.",[13,14,24],"Other: Gait Training",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Prism adaptation therapy (PAT) + Electrical stimulation (E-stim)","PAT requires one to wear prism lenses while making arm-reaching movements toward visual targets. For treating left-sided neglect, a person wears the prism lenses that shift the visual field, including the images of the target and of one's own reaching arm, certain degrees to the right depending on the diopter of the lens (e.g., the 20-diopter lens shifts the visual field by 11.4 degrees). The visual system adapts over the repetitive practice of the arm reaching toward the target. The person eventually achieves success with a leftward movement reaching the actual target. Electrical stimulation (E-stim) involves parameters and settings commonly used in clinical practice as well as research for pain relief and other applications, commonly referred to as transcutaneous electrical nerve stimulation (TENS). TENS and E-stim are delivered using FDA-approved, commercially available portable clinical transcutaneous electrical stimulators (e.g. Empi TENS Unit).",[16,20,9],[32],"PAT + E-stim",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Prism adaptation therapy (PAT) + Sham Stimulator","Participants in the PAT with sham stim condition group will receive sham electrical stimulation treatment (electrodes will be attached but the stimulator will not be turned on) to the left upper limb with the same placement of electrodes while undergoing PAT.",[16,20,9],[38],"Sham Stim",{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Gait Training","After PAT, participants will complete multiple 30-seconds to 4-minute bouts of walking on the treadmill or overground at speeds ranging from self-selected to fast speeds (faster than comfortable self-selected speed), with rest breaks between bouts.",[20],[44],"Gait Training After PAT",[46,49],{"name":47,"affiliation":5,"role":48},"Trisha Kesar, PT, PhD","PRINCIPAL_INVESTIGATOR",{"name":50,"affiliation":5,"role":48},"Fisayo Aloba, PT, DPT",[52],{"name":50,"role":53,"phone":54,"phoneExt":55,"email":56},"CONTACT","404-712-5803",null,"olufisayo.aloba@emory.edu",[58,74,81],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Emory Rehabilitation Hospital","RECRUITING","Atlanta","Georgia","30322","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-84.38798,33.749,{"lat":70,"lon":69},[73],{"name":50,"role":53,"phone":55,"phoneExt":55,"email":56},{"facility":75,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"Emory University Hospital (EUH)",{"type":67,"coordinates":77},[69,70],{"lat":70,"lon":69},[80],{"name":50,"role":53,"phone":55,"phoneExt":55,"email":56},{"facility":82,"status":60,"city":61,"state":62,"zip":83,"country":64,"countryCode":65,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Executive Park","30329",{"type":67,"coordinates":85},[69,70],{"lat":70,"lon":69},[88],{"name":50,"role":53,"phone":55,"phoneExt":55,"email":56},{"type":48,"investigatorFullName":90,"investigatorTitle":91,"investigatorAffiliation":5,"oldNameTitle":55,"oldOrganization":55},"Trisha Kesar","Associate Professor",[93],{"name":94,"class":95},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100520188","spatial-motor-stroke-rehab-study-100520188",false,"NCT06053320","Spatial-Motor Stroke-Rehab Study","Novel Spatial-Motor Approaches to Improve Spatial Neglect and Walking Deficits Post-Stroke","Inclusion Criteria:\n\nYoung Adults Able Bodied (YAB) Individuals\n\n* 18-30 years\n* Able-Bodied (healthy without any physical disability or neurological disorder)\n\nOlder Adults Able-Bodied Individuals (OAB)\n\n* 45-90 years\n* Able-Bodied (healthy without any physical disability or neurological disorder)\n\nIndividuals with right hemisphere stroke (40-90 years)\n\n* \\>3 months following stroke.\n* Presence of Aiming SN\n* Ability to walk \\>10m with or without assistive devices.\n* Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4\u002F5 on the Medical Research Council Scale\n* Ability to follow 3-stage commands and provide informed consent.\n\nExclusion Criteria:\n\nYoung Adults Able-Bodied (YAB) Individuals and Older Adults Able-Bodied Individuals (OAB)\n\n* History or evidence of orthopedic or physical disability\n* History or evidence of neurological pathology\n* Pregnancy (female)\n* Uncontrolled hypertension\n* Cardiac pacemaker or other implanted electronic system\n* Presence of skin conditions preventing the electrical stimulation setup\n* Impaired sensation in the left upper limb.\n* Bruises or cuts at the stimulation electrode placement site\n* Concurrent enrollment in rehabilitation or another investigational study.\n* History or evidence of orthopedic or physical disability interfering with study procedures\n* History or evidence of neurological pathology or disorder\n* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures\n* Contraindications to TMS, such as metal implants, medications that can increase cortical excitability, and unexplained dizziness in the past 6 months\n\nIndividuals with right hemisphere stroke (40-90 years)\n\n* History or brainstem strokes\n* Cerebellar disorders\n* Impaired sensation in the left upper limb.\n* History of other neurological disorders\n* Uncontrolled hypertension\n* Cardiac pacemaker or other implanted electronic system\n* Pregnancy (female)\n* Presence of skin condition\n* Bruises at the electrode placement site\n* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures\n* Contraindications to TMS, such as metal implants in the brain, medications that will increase cortical excitability, etc.",true,"ALL","18 Years","90 Years",{"count":108,"type":109},65,"ESTIMATED","INTERVENTIONAL",[112],"NA","The purpose of this study is to understand how prism adaptation training with and without electrical stimulation changes visuospatial behavior, motor system neurophysiology, and walking dysfunction.",[115,116],"Spatial Neglect","Stroke",[118,119,120],"Post-stroke","Prism Adaptation Therapy (PAT)","Walking","2026-05-18",{"date":123,"type":124},"2026-05-20","ACTUAL",{"date":126,"type":124},"2023-04-11",{"date":128,"type":109},"2026-09",{"name":5,"class":6},3]