[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623509":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":38,"locations":48,"responsibleParty":65,"collaborators":30,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":30,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":30,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":51,"whyStopped":30,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,13,19],{"label":9,"type":6,"description":10,"interventionNames":11},"No stimulation","Participants complete the study motor tasks and assessments without transcutaneous spinal cord stimulation (tSCS).",[12],"Other: No Stimulation",{"label":14,"type":15,"description":16,"interventionNames":17},"Conventional tSCS","ACTIVE_COMPARATOR","Participants complete the same experimental tasks and assessments while receiving conventional, non-invasive transcutaneous spinal cord stimulation (tSCS) using a single cathode and 30 Hz.",[18],"Device: Conventional tSCS",{"label":20,"type":21,"description":22,"interventionNames":23},"Spatiotemporal tSCS","EXPERIMENTAL","Participants complete the same tasks and assessments while receiving spatiotemporal tSCS in which stimulation parameters are systematically varied across sessions, including electrode location\u002Fconfiguration (spatial control), frequency, and amplitude (temporal\u002Fintensity control), to optimize targeted muscle recruitment and voluntary motor output.",[24],"Device: Spatiotemporal tSCS",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"No Stimulation","Participants complete motor tasks and outcome assessments with no spinal cord stimulation applied.",[9],null,{"type":32,"name":14,"description":33,"armGroupLabels":34,"otherNames":30},"DEVICE","Non-invasive transcutaneous spinal cord stimulation (tSCS) is delivered at 30 Hz using a single cathode electrode targeting the lumbar spinal cord to reinforce leg motor output during study tasks",[14],{"type":32,"name":20,"description":36,"armGroupLabels":37,"otherNames":30},"Stimulation parameters, including electrode location, stimulation frequency, and stimulation amplitude, are systematically varied to reinforce leg motor output during study tasks",[20],[39,44],{"name":40,"role":41,"phone":42,"phoneExt":30,"email":43},"Ismael Seáñez, PhD","CONTACT","314-935-7665","ismaelseanez@wustl.edu",{"name":45,"role":41,"phone":46,"phoneExt":30,"email":47},"Carolyn Atkinson, BS","314-935-4530","a.carolyn@wustl.edu",[49],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Washington University, St. Louis","RECRUITING","St Louis","Missouri","63130","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-90.19789,38.62727,{"lat":61,"lon":60},[64],{"name":40,"role":41,"phone":42,"phoneExt":30,"email":43},{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Ismael Seáñez","Assistant Professor of Biomedical Engineering and Neurosurgery","100623509","spatiotemporal-tscs-in-spinal-cord-injury-100623509",false,"NCT07397559","Spatiotemporal tSCS in Spinal Cord Injury","Spatiotemporal Control of Transcutaneous Spinal Cord Stimulation for Motor Function in SCI","Inclusion Criteria:\n\n1. Age between 16 and 65 years.\n2. Have a spinal cord injury (neurological level C3-T12) that occurred ≥1 year (chronic stage) prior to enrollment.\n3. American Spinal Injury Association (ASIA) Impairment Scale (AIS) classification C or D\n4. Able to voluntarily contract (motor score ≥ 1) at least two leg muscles (visual or palpable contraction).\n5. Use of prescription medication(s) for control of spasticity has not changed in the last 2 weeks\n6. Able to provide consent\n7. Ability to follow multiple instructions and communicate pain or discomfort\n\nExclusion Criteria:\n\n1. Progressive spinal lesions, including degenerative disorders of the spinal cord\n2. Pregnant, planning to become pregnant, or currently breastfeeding\n3. History of cardiopulmonary disease or cardiac symptoms\n4. Implanted stimulators of any type (baclofen pump, epidural spinal stimulator, cardiac defibrillator, pace-maker, etc.)\n5. Presence of orthopedic conditions that would negatively affect participation in leg exercise\n6. History of autonomic dysreflexia that is severe, unstable, and\u002For uncontrolled\n7. Unstable or significant medical conditions that can interfere with exercise or neurophysiological evaluations, such as severe neuropathic pain, depression, mood disorders, or other cognitive disorders\n8. Spasms that limit the ability to participate in leg exercise activity\n9. Breakdown in skin area that will be in contact with electrodes","ALL","16 Years","65 Years",{"count":80,"type":81},48,"ESTIMATED","INTERVENTIONAL",[84],"NA","Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in muscle recruitment compared to invasive approaches limits the type of rehabilitation exercises that can be practiced. This project studies how spatial, frequency, and amplitude control of stimulation can be used to selectively target different neural pathways and muscle groups.",[87],"Spinal Cord Injuries (SCI)",[89,90,91],"spinal cord injury","transcutaneous spinal cord stimulation","rehabilitation","2026-02-09",{"date":94,"type":95},"2026-02-12","ACTUAL",{"date":97,"type":95},"2026-01-19",{"date":99,"type":81},"2030-08-31",{"name":5,"class":6},1]