[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100522897":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":48,"collaborators":20,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":20,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":20,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Speech Sounds","EXPERIMENTAL","Participants will hear repeated speech sounds while wearing a neuroimaging cap.",[13],"Behavioral: Mismatch negativity",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Mismatch negativity","Event related potentials are compared between frequent and infrequent speech sounds (i.e., \"ba\" vs \"da\").",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Elizabeth Smith, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","513-517-1383","elizabeth.smith3@cchmc.org",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Cincinnati Children'S Hospital","RECRUITING","Cincinnati","Ohio","45229-3026","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-84.51439,39.12711,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":20,"phoneExt":20,"email":29},"Elizabeth Smith",{"type":49,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100522897","speech-in-noise-perception-in-autism-and-fragile-x-100522897",false,"NCT06088589","Speech-in-noise Perception in Autism and Fragile X","Cortical Mechanisms of Speech in Noise Perception in Autism and Fragile X Syndrome","Inclusion Criteria:\n\n1. normal audiograms (PTA ≤ 20 dB HL)\n2. corrected 20\u002F20 vision (Snellen chart)\n3. no history of premature birth (prior to 36 weeks gestation)\n4. no medications known to affect EEG signal\n5. English as the first language\n\nInclusion for the Autism group requires the following:\n\n1\\) diagnosis of Autism Spectrum Disorder either based on previous ADOS administration and developmental history, or confirmed via ADOS and developmental history\n\nInclusion for the Autism + FXS group requires the following:\n\n1. Documented PCR\u002FSouthern Blot genetic testing confirming full mutation FXS\n2. Diagnosis of Autism Spectrum Disorder, per Autism group.\n\nInclusion for the Typically Developing group requires the following:\n\n1. no siblings or parents with an Autism Spectrum Disorder or Fragile X Syndrome\n2. no current neurological or psychiatric diagnoses\n3. IQ over 75\n\nExclusion Criteria:\n\n* Hearing loss or uncorrected vision loss\n* history of premature birth (prior to 36 weeks gestation)",true,"ALL","15 Years","35 Years",{"count":62,"type":63},60,"ESTIMATED","INTERVENTIONAL",[66],"NA","The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\\[s\\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise?\n\nParticipants will complete the following:\n\n* hearing tests\n* cognitive and behavioral measures\n* questionnaires about their symptoms\n* both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.",[69,70],"Autism Spectrum Disorder","Fragile X Syndrome","2026-03-17",{"date":73,"type":74},"2026-03-19","ACTUAL",{"date":76,"type":74},"2023-11-10",{"date":78,"type":63},"2026-04-30",{"name":5,"class":6},1]