[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553912":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":34,"centralContacts":38,"locations":43,"responsibleParty":58,"collaborators":60,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Yale University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Altered auditory feedback + fMRI","EXPERIMENTAL","Participants will perform learning tasks then undergo fMRI. This procedure will be repeated on day 2. Functional connectivity patterns between regions that predict learning will be assessed. Participants then leave the laboratory and return 24 hours later to assess retention of learning.",[13,14],"Device: fMRI","Behavioral: Adaptation",{"label":16,"type":10,"description":17,"interventionNames":18},"Control Condition","Participants in a control condition who will undergo the same procedures, without altered feedback",[13,14],[20,26,31],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","fMRI","To assess functional connectivity patterns between regions that predict learning.",[9,16],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"BEHAVIORAL","Adaptation","Auditory adaptation in speech",[9],{"type":27,"name":28,"description":32,"armGroupLabels":33,"otherNames":25},"Auditory baseline in speech",[16],[35],{"name":36,"affiliation":5,"role":37},"David Ostry","PRINCIPAL_INVESTIGATOR",[39],{"name":36,"role":40,"phone":41,"phoneExt":25,"email":42},"CONTACT","2038656163","david.ostry@yale.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":25},"Yale Child Study Center","RECRUITING","New Haven","Connecticut","06520","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-72.92816,41.30815,{"lat":56,"lon":55},{"type":59,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[61],{"name":62,"class":63},"National Institute on Deafness and Other Communication Disorders (NIDCD)","NIH","100553912","speech-motor-learning-and-retention-aim-3-100553912",false,"NCT06492252","Speech Motor Learning and Retention (Aim 3)","Sensorimotor Basis of Speech Motor Learning and Retention","Inclusion Criteria:\n\n* Fluent English speakers\n* Right-handed\n* Normal hearing\n* No speech disorder or reading disability\n\nExclusion Criteria:\n\n* Cardiac pacemaker\n* Aneurysm clip\n* Heart or Vascular clip\n* Prosthetic valve\n* Metal implants\n* Metal in brain, skull, or spinal cord\n* Implanted neurostimulator\n* Medication infusion device\n* Cochlear implant or tinnitus (ringing in ears)\n* Personal and\u002For family history of epilepsy or other neurological disorders or history of head concussion\n* Psychoactive medications\n* Pregnancy",true,"ALL","18 Years","40 Years",{"count":76,"type":77},50,"ESTIMATED","INTERVENTIONAL",[80],"NA","The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.",[83],"Speech",[85,86],"Speech Motor Learning","Retention","2026-05-21",{"date":89,"type":90},"2026-05-26","ACTUAL",{"date":92,"type":90},"2026-05-04",{"date":94,"type":77},"2029-05-31",{"name":5,"class":6},1]