[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551992":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":49,"locations":54,"responsibleParty":69,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":31,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":31,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":57,"whyStopped":31,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Yale University","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Speech Motor Learning and Retention Aim 1","EXPERIMENTAL","Aim 1: Participants will perform learning tasks while receiving altered\u002Funaltered auditory feedback with cTBS applied to the appropriate area of the brain following learning. Retention of learning is assessed 24 hours later.",[13,14],"Device: continuous theta-burst stimulation (cTBS)","Behavioral: Adaptation",{"label":16,"type":10,"description":17,"interventionNames":18},"Speech Motor Learning and Retention Aim 2","Aim 2: Participants will perform learning tasks combined with shifted auditory feedback. Motor cortical excitability will be measured using single-pulse TMS to elicit motor evoked potentials.",[14,19],"Device: Single pulse Transcranial magnetic stimulation (TMS)",{"label":21,"type":10,"description":22,"interventionNames":23},"Speech Motor Learning and Retention Aim 3","Aim 3: Participants will have fMRI with behavioral measures of speech motor learning.",[14,24],"Device: fMRI",[26,32,37,41],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","continuous theta-burst stimulation (cTBS)","cTBS stimulation will be applied to different areas of the brain following learning. Stimulation will take place following learning in order to block motor memory retention.",[9],null,{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":31},"BEHAVIORAL","Adaptation","Auditory adaptation in speech",[9,16,21],{"type":27,"name":38,"description":39,"armGroupLabels":40,"otherNames":31},"Single pulse Transcranial magnetic stimulation (TMS)","TMS will be delivered 10 times in each motor evoked potentials (MEP) recording block.",[16],{"type":27,"name":42,"description":43,"armGroupLabels":44,"otherNames":31},"fMRI","To assess functional connectivity patterns between regions that predict learning.",[21],[46],{"name":47,"affiliation":5,"role":48},"David Ostry","PRINCIPAL_INVESTIGATOR",[50],{"name":47,"role":51,"phone":52,"phoneExt":31,"email":53},"CONTACT","2038656163","david.ostry@yale.edu",[55],{"facility":56,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":31},"Yale Child Study Center","RECRUITING","New Haven","Connecticut","06520","United States","US",{"type":64,"coordinates":65},"Point",[66,67],-72.92816,41.30815,{"lat":67,"lon":66},{"type":70,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[72],{"name":73,"class":74},"National Institute on Deafness and Other Communication Disorders (NIDCD)","NIH","100551992","speech-motor-learning-and-retention-master-protocol-100551992",false,"NCT06467292","Speech Motor Learning and Retention (Master Protocol)","Sensorimotor Basis of Speech Motor Learning and Retention","Inclusion Criteria:\n\n* Fluent English speakers\n* Right-handed\n* Normal hearing\n* No speech disorder or reading disability\n\nExclusion Criteria:\n\n* Cardiac pacemaker\n* Aneurysm clip\n* Heart or Vascular clip\n* Prosthetic valve\n* Metal implants\n* Metal in brain, skull, or spinal cord\n* Implanted neurostimulator\n* Medication infusion device\n* Cochlear implant or tinnitus (ringing in ears)\n* Personal and\u002For family history of epilepsy or other neurological disorders or history of head concussion\n* Psychoactive medications\n* Pregnancy",true,"ALL","18 Years","40 Years",{"count":87,"type":88},330,"ESTIMATED","INTERVENTIONAL",[91],"NA","The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well.",[94],"Speech",[96,97],"Speech Motor Learning","Retention","2026-02-17",{"date":100,"type":101},"2026-02-19","ACTUAL",{"date":103,"type":101},"2024-10-01",{"date":105,"type":88},"2029-05-31",{"name":5,"class":6},1]