[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600740":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":91,"collaborators":93,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":40,"studyType":116,"phases":117,"briefSummary":119,"conditions":120,"keywords":40,"overallStatus":123,"whyStopped":40,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Murdoch Childrens Research Institute","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Long-Short PRT Sequence","EXPERIMENTAL","Long PRT set during first treatment period; Short PRT set during second treatment period",[13,14],"Other: Long PRT","Other: Short PRT",{"label":16,"type":10,"description":17,"interventionNames":18},"Short-Long PRT Sequence","Short PRT set during first treatment period; Long PRT set during second treatment period",[13,14],[20,26],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Long PRT","PRT (in seconds) set at 75% of inspiratory time (in seconds)",[9,16],[25],"Long Pressure Rise Time",{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Short PRT","PRT (in seconds) set at 33% of inspiratory time (in seconds).",[9,16],[31],"Short Pressure Rise Time",[33],{"name":34,"affiliation":5,"role":35},"Kristin N Ferguson, BSc MBBS","PRINCIPAL_INVESTIGATOR",[37],{"name":34,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","+61383416200",null,"kristin.ferguson@mcri.edu.au",[43,62,77],{"facility":44,"status":40,"city":45,"state":46,"zip":40,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Mercy Hospital for Women","Heidelberg","Victoria","Australia","AU",{"type":50,"coordinates":51},"Point",[52,53],145.06667,-37.75,{"lat":53,"lon":52},[56,60],{"name":57,"role":38,"phone":58,"phoneExt":40,"email":59},"Brett Manley, MBBS(Hons) FRACP PhD","61384584444","brett.manley@unimelb.edu.au",{"name":61,"role":38,"phone":40,"phoneExt":40,"email":41},"Kristin Ferguson, BSc MBBS",{"facility":63,"status":40,"city":64,"state":46,"zip":65,"country":47,"countryCode":48,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"The Royal Women's Hospital","Parkville","3051",{"type":50,"coordinates":67},[68,69],144.95,-37.78333,{"lat":69,"lon":68},[72,76],{"name":73,"role":38,"phone":74,"phoneExt":40,"email":75},"Kate Hodgson, BMSc MBBS(Hons) PhD","61383452000","kate.hodgson@thewomens.org.au",{"name":61,"role":38,"phone":40,"phoneExt":40,"email":41},{"facility":78,"status":40,"city":79,"state":46,"zip":80,"country":47,"countryCode":48,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Joan Kirner Women's and Children's Hospital","Saint Albans","3021",{"type":50,"coordinates":82},[83,84],144.8,-37.73333,{"lat":84,"lon":83},[87],{"name":88,"role":38,"phone":89,"phoneExt":40,"email":90},"Arun Sett, MBBS(Hons) FRACP PhD","61383451333","arun.sett@wh.org.au",{"type":92,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR",[94,96,99],{"name":95,"class":6},"Mercy Hospital for Women, Australia",{"name":97,"class":98},"Royal Women's Hospital, Melbourne, Australia","UNKNOWN",{"name":100,"class":101},"Western Health, Australia","OTHER_GOV","100600740","speed-of-lung-inflation-during-ventilation-of-extremely-preterm-infants-100600740",false,"NCT07101419","Speed of Lung Inflation During Ventilation of Extremely Preterm Infants","Longer Pressure Rise Time During Mechanical Ventilation of Extremely Preterm Infants: A Randomised Crossover Trial","FLOW-VENT","Inclusion Criteria:\n\n* Admitted to participating neonatal intensive care unit\n* Born between 22+0 to 27+6 weeks' gestation\n* Current weight ≥400 grams\n* Receiving synchronised, patient-triggered, volume-targeted (all breaths) conventional mechanical ventilation (Pressure Control-Assist Control + Volume Guarantee \\[PC-AC+VG\\] mode on Dräger Babylog VN500\u002F800 ventilators) initiated within 72-hours post birth\n* Postnatal age ≥6 hours and ≤7 days\n* Received surfactant therapy\n* Clinically stable (as per treating and research team consensus)\n* Parent(s)\u002Flegal guardian provides prospective informed consent.\n\nExclusion Criteria:\n\n* Major congenital anomaly involving the cardiac, respiratory or gastrointestinal systems, or a known genetic syndrome or diagnosis that might affect respiratory course and outcomes\n* Severe pulmonary hypoplasia due to anhydramnios or oligohydramnios before 22 weeks in which the neonatal consultant anticipates that pulmonary hypoplasia related respiratory failure will be the major respiratory problem in early postnatal life\n* Receiving (or expected to receive within the next 12 hours) any other mode of mechanical ventilation including synchronised intermittent mandatory ventilation (SIMV), pressure support ventilation (PSV) or high-frequency oscillatory ventilation\n* Planned for extubation from mechanical ventilation within the next 12 hours.","ALL","6 Hours","7 Days",{"count":114,"type":115},68,"ESTIMATED","INTERVENTIONAL",[118],"NA","Babies born extremely preterm (\\\u003C28 weeks of pregnancy) require support to breathe. Some babies require help to breathe from a breathing machine (mechanical ventilator). While this keeps babies alive, it may damage their lungs. To reduce this damage, doctors and nurses take particular care to try and provide the gentlest breathing support possible. However, evidence is still required to determine how to best support babies' breathing, whilst preventing lung damage and longer-term lung problems.\n\nThis clinical trial aims to compare two ways of adjusting a common setting on the breathing machine. This setting is called the pressure rise time or PRT. The PRT determines how quickly the breathing machine inflates a premature baby's lungs. A short PRT quickly inflates the lungs. A long PRT inflates the lungs more slowly. Previous research suggests that more slowly inflating the baby's lungs may cause less lung damage and still allow oxygen to be delivered to and carbon dioxide to be cleared from the lungs. However, larger studies are required to determine whether this should become the standard treatment.\n\nThis study investigates whether inflating the baby's lungs more slowly (long PRT) using the breathing machine is as effective as the PRT setting currently used (short PRT, more quickly inflating the lungs).\n\nThe main question it aims to answer is: Does how quickly the breathing machine inflates an extremely preterm baby's lung impact their oxygen levels?",[121,122],"Respiratory Distress Syndrome, Newborn","Respiratory Distress Syndrome in Premature Infant","NOT_YET_RECRUITING","2026-06-21",{"date":126,"type":127},"2026-06-24","ACTUAL",{"date":129,"type":115},"2027-02",{"date":131,"type":115},"2028-02",{"name":5,"class":6},3]