[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604082":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":19,"collaborators":10,"id":23,"slug":24,"hasResults":25,"nctId":26,"briefTitle":27,"officialTitle":28,"acronym":10,"eligibilityCriteria":29,"healthyVolunteers":25,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":10,"studyType":36,"phases":10,"briefSummary":37,"conditions":38,"keywords":10,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"1",null,[12],"Genetic: Sperm DNA fragmentation",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"GENETIC","Sperm DNA fragmentation","Estimation of sperm DFI level with sperm chromatin dispersion",[9],{"type":20,"investigatorFullName":21,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ali Deif Abdelghani Ghidan","Principal Investigator","100604082","sperdna-fragmentation-a-a-predictor-for-outcome-after-varicocelectomym-100604082",false,"NCT07144891","sperDNA Fragmentation a a Predictor for Outcome After Varicocelectomy,m","Sperm DNA Fragmentation Among Other Variableas a Predictor for Outcome After Varicocelectomy,","Inclusion Criteria:\n\n* Patients have been diagnosed with VC (GII and GIII) by physical examination and scrotal color Doppler ultrasonography.\n* Patients with stable relationships.\n* In the control group, those with high SDF.\n* Patients with documented infertility.\n* Normal female partners or having correctable cause of infertility.\n* Patients age from 20 to 45 years old.\n\nExclusion Criteria:\n\nPatients with a history of scrotal and spermatic cord injuries and congenital genitourinary abnormalities.\n\n* Patients with systemic or endocrine disease, cryptorchidism, hypogonadism, genital infection, hormonal treatment and azoospermic patients.\n* Recurrent varicocele.\n* Patients with any other disease that may cause VC (such as external kidney tumor, hydronephrosis, etc.)\n* Smoker patients and others risk factors (x ray, nuclear) workers\n* Abnormal or uncorrectable female factor. 7- Single patient.","MALE","20 Years","45 Years",{"count":34,"type":35},1,"ESTIMATED","OBSERVATIONAL","Varicocele is often associated with infertility and reduction in sperm quality, and it is one of the most common causes of reversible male infertility.\n\nThe exact mechanism of infertility caused due to varicocele formation remains unclear. One of the suggested theories is related to increased oxidative stress that causes sperm DNA damage, including DNA fragmentation, and is correlated with the decreased capacity of spermatozoa to fertilize oocytes during normal fertilization and assisted reproduction techniques. This is supported by the evidence that there is a higher prevalence of DNA fragmentation in varicocele patients and a correlation between the presence of varicocele and impaired sperm DNA integrity.\n\nSeveral tests have been developed to better assess the fertility potential of sperm, including those designed to measure sperm deoxyribonucleic acid (DNA) fragmentation (SDF). The sperm DNA fragmentation index (DFI) is a potential parameter for fertility investigation, reflecting sperm DNA integrity and damage.",[39],"DNA Damage","NOT_YET_RECRUITING","2025-08-20",{"date":43,"type":44},"2025-08-28","ACTUAL",{"date":46,"type":35},"2025-10-01",{"date":48,"type":35},"2026-10-01",{"name":5,"class":6}]