[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627530":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":36,"responsibleParty":52,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":19,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":83,"whyStopped":19,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Rennes University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Epigenetic analysis in semen samples","EXPERIMENTAL","30 men with hodgkin lymphoma will be followed during 24 months in order to search epigenetic modifications in male gametes",[13],"Other: Additional semen samples",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Additional semen samples","5 additional semen samples : before chemotherapy, at month 6, 12, 18 and 24 after chemotherapy. Each sperm sample will be stored in liquid nitrogen and sent to Institut National de la Recherche Scientifique (INRS), Quebec, Canada for epigenetic analysis.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Géraldine DELBES, PhD","Institut National de la Recherche Scientifique (INRS), Québec, Canada","STUDY_CHAIR",[26,32],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Tony MARCHAND, MD, PhD","CONTACT","02 99 28 42 91","+33","tony.marchand@chu-rennes.fr",{"name":33,"role":28,"phone":34,"phoneExt":30,"email":35},"Célia RAVEL, MD, PhD","02 99 26 59 16","celia.ravel@chu-rennes.fr",[37],{"facility":38,"status":19,"city":39,"state":19,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Centre Hospitalier Universitaire de Rennes","Rennes","35033","France","FR",{"type":44,"coordinates":45},"Point",[46,47],-1.67431,48.11109,{"lat":47,"lon":46},[50,51],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},{"name":33,"role":28,"phone":34,"phoneExt":30,"email":35},{"type":53,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[55],{"name":56,"class":57},"Institut National de la Recherche Scientifique - Centre Armand Frappier Santé Biotechnologie","UNKNOWN","100627530","sperm-epigenome-in-hodgkin-lymphoma-100627530",false,"NCT07449832","Sperm Epigenome in Hodgkin Lymphoma","Multiparametric Detection and Preventive Approaches of Cancer Treatment-induced Epigenetic Instability in the Male Germline.","SPELH","Inclusion Criteria:\n\n* Men aged 18 to 45 years\n* Diagnosed with Hodgkin lymphoma\n* Treatment-naïve to any cytotoxic therapy\n* Whose treatment regimen consists of 4 to 6 cycles of ABVD or BrECADD\n* Beneficiaries of the French social security system\n* Not opposed to participating in research\n\nExclusion Criteria:\n\n* Patient receiving abdominal radiotherapy",true,"MALE","18 Years","45 Years",{"count":71,"type":72},50,"ESTIMATED","INTERVENTIONAL",[75],"NA","Cancer treatments can have long-term effects on fertility. In men, scientific studies suggest that the process of sperm formation (spermatogenesis) may be disrupted even years after recovery, with potential consequences not only for fertility but also for the health of offspring. The effects of chemotherapy on sperm quality, particularly on DNA packaging (chromatin) and the epigenome, remain poorly understood. Therefore, further in-depth studies are needed to determine whether a history of cancer and chemotherapy treatment may impact the health of children fathered by young male survivors.\n\nWe therefore propose to conduct a clinical study aimed at better understanding the mechanisms by which chemotherapies affect spermatogenesis. The results could provide answers by identifying the effects of these drugs on the fertility of young male cancer patients in the long term and the sperm epigenome indicative of the health of the progeny.",[78],"Hodgkin Disease Lymphoma",[80,81,82],"epigenetic","chemotherapy","male gametes","NOT_YET_RECRUITING","2026-05-11",{"date":86,"type":87},"2026-05-14","ACTUAL",{"date":89,"type":72},"2026-06-01",{"date":91,"type":72},"2030-01-01",{"name":5,"class":6},1]