[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639626":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":32,"responsibleParty":49,"collaborators":19,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":19,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":35,"whyStopped":19,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Columbia University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Paired brain and nerve stimulation","EXPERIMENTAL","With this session, participants will receive paired motor cortical stimulation and median nerve stimulation at sub-threshold intensities, timed to converge in the cervical spinal cord simultaneously.",[13],"Device: Paired brain and nerve stimulation",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","This utilizes pairing of repetitive transcranial magnetic stimulation (rTMS) and peripheral nerve stimulation (rPNS) timed to converge in the cervical spinal cord.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Jason Carmel, MD, PhD","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Shaker Dukkipati, MD, PhD","CONTACT","2123046501","sd3850@cumc.columbia.edu",{"name":22,"role":27,"phone":19,"phoneExt":19,"email":31},"jbc28@cumc.columbia.edu",[33],{"facility":34,"status":35,"city":36,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Columbia University Irving Medical Center","RECRUITING","New York","10040","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-74.00597,40.71427,{"lat":44,"lon":43},[47,48],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},{"name":22,"role":27,"phone":19,"phoneExt":19,"email":31},{"type":23,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Jason Carmel","Weinberg Family Associate Professor of Neurology (in Orthopedic Surgery); Chief of the Division of Child Neurology","100639626","spinal-cord-associative-plasticity-in-cerebral-palsy-100639626",false,"NCT07607665","Spinal Cord Associative Plasticity in Cerebral Palsy","Paired Stimulation of Hand Motor Cortex and Median Nerve to Induce Spinal Cord Plasticity in Hemiplegic Cerebral Palsy","SCAP-CP","Inclusion Criteria:\n\n* Maintenance of caffeine and exercise levels at time of sessions\n* Ability to provide informed consent\n* Manual ability classification system (MACS) level I to III\n\nExclusion Criteria:\n\n* History of seizures in last two years\n* Use of medications that lower seizure threshold\n* History of implanted equipment including stimulators\u002Fpacemakers","ALL","18 Years","80 Years",{"count":64,"type":65},25,"ESTIMATED","INTERVENTIONAL",[68],"NA","Associative plasticity has been used to promote functional recovery from conditions affecting movement. The long term goal of this project is to use electrical stimulation techniques to improve arm and hand function. The goal of this prospective experimental study in adults with hemiplegic cerebral palsy (hCP) is to test the effects of pairing hand motor cortical and median nerve stimulation targeted to induce plasticity in the cervical spinal cord. Based on preliminary data in neurotypical adults, the investigators are testing the effects of this approach in adults with hCP.\n\nThis study will first verify the present stimulation parameters as sufficient to promote induction of associative plasticity of sensorimotor connections for manual dexterity in adults with hCP. This will be assessed through neurophysiological, biomechanical, and clinical functional outcome measures. Successful pairing showing meaningful improvements in dexterity could then be used as an impetus for a larger study examining the efficacy of SCAP in people with hCP.",[71],"Hemiplegic Cerebral Palsy",[73,74,75,76,77,78,79,80,81,82,83],"cervical spinal cord","spinal cord associative plasticity","SCAP","corticospinal","manual dexterity","cerebral palsy","motor evoked potential","hemiplegia","adults with CP","sensory","somatosensation","2026-05-26",{"date":86,"type":87},"2026-05-28","ACTUAL",{"date":89,"type":65},"2026-06",{"date":91,"type":65},"2032-05",{"name":5,"class":6},1]