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The total sample will be composed of 70 patients (n=9 pts per participating unit).",[13,19],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},"Anna Estraneo, MD","CONTACT","3396418648","39","aestraneo@dongnocchi.it",{"name":20,"role":15,"phone":21,"phoneExt":17,"email":22},"Alfonso Magliacano, PhD","3387389414","amagliacano@dongnocchi.it",[24,48,67,85,105,123,141,159],{"facility":25,"status":26,"city":27,"state":28,"zip":29,"country":28,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Coma Science Group, GIGA-Consciousness, University of Liege","NOT_YET_RECRUITING","Liège","Belgium","4000","BE",{"type":32,"coordinates":33},"Point",[34,35],5.56749,50.63373,{"lat":35,"lon":34},[38,41,43,46],{"name":39,"role":15,"phone":10,"phoneExt":10,"email":40},"Olivia Gosseries, PhD","ogosseries@uliege.be",{"name":39,"role":42,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":44,"role":45,"phone":10,"phoneExt":10,"email":10},"Aurore Thibaut, PhD","SUB_INVESTIGATOR",{"name":47,"role":45,"phone":10,"phoneExt":10,"email":10},"Youssra Mezoudi, M.Sc.",{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":52,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Therapiezentrum Burgau","RECRUITING","Burgau","Germany","89331","DE",{"type":32,"coordinates":56},[57,58],10.40989,48.43159,{"lat":58,"lon":57},[61,64,65],{"name":62,"role":15,"phone":10,"phoneExt":10,"email":63},"Andreas Bender, MD","a.bender@therapiezentrum-burgau.de",{"name":62,"role":42,"phone":10,"phoneExt":10,"email":10},{"name":66,"role":45,"phone":10,"phoneExt":10,"email":10},"Martin Rosenfelder, PhD",{"facility":68,"status":50,"city":69,"state":52,"zip":70,"country":52,"countryCode":54,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Dipartimento di Neurologia, LMU Hospital, LMU Munich","Munich","81377",{"type":32,"coordinates":72},[73,74],11.57549,48.13743,{"lat":74,"lon":73},[77,80,81,83],{"name":78,"role":15,"phone":10,"phoneExt":10,"email":79},"Konstantinos Dimitriadis","konstantin.dimitriadis@med.unimuenchen.de",{"name":78,"role":42,"phone":10,"phoneExt":10,"email":10},{"name":82,"role":45,"phone":10,"phoneExt":10,"email":10},"Moritz Schmidbauer",{"name":84,"role":45,"phone":10,"phoneExt":10,"email":10},"Julia Zibold",{"facility":86,"status":50,"city":87,"state":88,"zip":89,"country":90,"countryCode":91,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Polo Specialistico Riabilitativo Fondazione Don Carlo Gnocchi ONLUS","Sant'Angelo dei Lombardi","AV","83054","Italy","IT",{"type":32,"coordinates":93},[94,95],15.17535,40.92937,{"lat":95,"lon":94},[98,100,101,102,103],{"name":99,"role":15,"phone":16,"phoneExt":17,"email":18},"Anna Estraneo, PhD",{"name":20,"role":15,"phone":21,"phoneExt":17,"email":22},{"name":14,"role":42,"phone":10,"phoneExt":10,"email":10},{"name":20,"role":45,"phone":10,"phoneExt":10,"email":10},{"name":104,"role":45,"phone":10,"phoneExt":10,"email":10},"Giovanni Scarano, BS",{"facility":106,"status":50,"city":107,"state":90,"zip":108,"country":90,"countryCode":91,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Unità Gravi Cerebrolesioni - Dipartimento Neuroscienze - Azienda Ospedaliera - Universitaria Ferrara","Ferrara","44124",{"type":32,"coordinates":110},[111,112],11.62057,44.83804,{"lat":112,"lon":111},[115,118,119,121],{"name":116,"role":15,"phone":10,"phoneExt":10,"email":117},"Susanna Lavezzi","s.lavezzi@ospfe.it",{"name":116,"role":42,"phone":10,"phoneExt":10,"email":10},{"name":120,"role":45,"phone":10,"phoneExt":10,"email":10},"Valentina Bonsangue",{"name":122,"role":45,"phone":10,"phoneExt":10,"email":10},"Sofia Straudi",{"facility":124,"status":50,"city":125,"state":90,"zip":126,"country":90,"countryCode":91,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"IRCCS Fondazione Don Gnocchi ONLUS","Florence","50143",{"type":32,"coordinates":128},[129,130],11.24626,43.77925,{"lat":130,"lon":129},[133,136,137,139],{"name":134,"role":15,"phone":10,"phoneExt":10,"email":135},"Bahia Hakiki, PhD","bhakiki@dongnocchi.it",{"name":134,"role":42,"phone":10,"phoneExt":10,"email":10},{"name":138,"role":45,"phone":10,"phoneExt":10,"email":10},"Andrea Mannini, PhD",{"name":140,"role":45,"phone":10,"phoneExt":10,"email":10},"Piergiuseppe Liuzzi, PhD",{"facility":142,"status":50,"city":143,"state":90,"zip":144,"country":90,"countryCode":91,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"IRCCS Santa Maria Nascente Fondazione Don Gnocchi ONLUS","Milan","20148",{"type":32,"coordinates":146},[147,148],9.18951,45.46427,{"lat":148,"lon":147},[151,154,155,157],{"name":152,"role":15,"phone":10,"phoneExt":10,"email":153},"Angela Comanducci, PhD","acomanducci@dongnocchi.it",{"name":152,"role":42,"phone":10,"phoneExt":10,"email":10},{"name":156,"role":45,"phone":10,"phoneExt":10,"email":10},"Tiziana Atzori",{"name":158,"role":45,"phone":10,"phoneExt":10,"email":10},"Chiara-Camilla Derchi",{"facility":160,"status":50,"city":161,"state":162,"zip":163,"country":162,"countryCode":164,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Instituto de Rehabilitación Neurológica IRENEA","Valencia","Spain","46007","ES",{"type":32,"coordinates":166},[167,168],-0.37966,39.47391,{"lat":168,"lon":167},[171,174,175,177],{"name":172,"role":15,"phone":10,"phoneExt":10,"email":173},"Enrique Noé, MD","enoe@comv.es",{"name":172,"role":42,"phone":10,"phoneExt":10,"email":10},{"name":176,"role":45,"phone":10,"phoneExt":10,"email":10},"Roberto Llorens, PhD",{"name":178,"role":45,"phone":10,"phoneExt":10,"email":10},"Alejandro Galvao, PhD",{"type":180,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[182,183,185,187,189,192],{"name":49,"class":6},{"name":184,"class":6},"University of Liege",{"name":186,"class":6},"University Hospital Munich",{"name":188,"class":6},"Ludwig-Maximilians - University of Munich",{"name":190,"class":191},"VITHAS Valencia (Spain)","UNKNOWN",{"name":193,"class":191},"Lavezzi Susanna, Local Health Unit, Ferrara (IT)","100540913",false,"NCT06323031","Spontaneous Eye Blinking in Disorders of Consciousness","Spontaneous Eye Blinking as a Diagnostic and Prognostic Marker in Patients With Disorders of Consciousness After Severe Acquired Brain Injury","Blink-DoC","Inclusion Criteria:\n\n* clinical diagnosis of DoC (UWS, MCS minus, MCS plus) following repeated clinical evaluation (at least four CRS-R in a week)\n* age ≥ 18 years\n* time post-onset ≤6 months\n* Previous sABI of any etiology (traumatic, vascular, anoxic, mixed, etc.)\n* Negative anamnesis for neurological or psychiatric disorders.\n\nExclusion Criteria:\n\n* unstable clinical conditions (e.g. respiratory failure, fever, status epilepticus, etc.);\n* ophthalmic diseases, or clinically detected peripheral damage in eyelid motility (e.g. orbital fracture);\n* intake of sedative drugs in the preceding 24 hours;\n* additional brain event following admission (e.g., stroke).",true,"ALL","18 Years",{"count":205,"type":206},70,"ESTIMATED","OBSERVATIONAL","Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and\u002For sensorimotor deficits in these patients. In this study the investigators aimed at exploring the diagnostic and prognostic validity of spontaneous eye blinking parameters (rate, amplitude, duration, variability) in a sample of patients with Disorders of Consciousness (DoC).\n\nThis is a multi-center prospective observational study conducted in patients with Severe Acquired Brain Injury (sABI) and DoC admitted to 8 European participating centers, with clinical data collection not deviating from routine practice. The study is non-commercial and will have a maximum total duration of 24 months.",[210],"Disorders of Consciousness",[210,212,213,214,215],"blinking","diagnosis","prognosis","rehabilitation","2025-09-24",{"date":218,"type":219},"2025-09-29","ACTUAL",{"date":221,"type":219},"2025-03-31",{"date":223,"type":206},"2026-06",{"name":5,"class":6},8]