[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602573":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":33,"locations":43,"responsibleParty":60,"collaborators":10,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Research Center Borstel","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Patients with suspected TB",null,[12],"Diagnostic Test: Biomarker-guided diagnostic tests",{"label":14,"type":10,"description":10,"interventionNames":15},"Other pulmonary infections (control group)",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DIAGNOSTIC_TEST","Biomarker-guided diagnostic tests","mRNA-Signature from blood; immunophenotyping from blood; MBLA from sputum, PATHFAST-LAM and EclLAM from sputum, stool, urine; CRISPR-Cas from blood; stool PCR; QuantiFERON(R)-TB Gold Plus.",[14,9],[23,27,30],{"name":24,"affiliation":25,"role":26},"Christoph Lange, Prof. Dr. Dr. h.c.","Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center","STUDY_CHAIR",{"name":28,"affiliation":29,"role":26},"Marylyn Martina Addo, Prof. Dr.","Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf",{"name":31,"affiliation":32,"role":26},"Stefan Schmiedel, Dr. med.","Division of Infectious Diseases, I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Thomas Theo Brehm, Dr. med.","CONTACT","+49 4537 188 2905","tbrehm@fz-borstel.de",{"name":40,"role":36,"phone":41,"phoneExt":10,"email":42},"Niklas Köhler, Dr. med.","+49 4537 188 8080","nkoehler@fz-borstel.de",[44],{"facility":32,"status":45,"city":46,"state":10,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Hamburg","20246","Germany","DE",{"type":51,"coordinates":52},"Point",[53,54],9.99302,53.55073,{"lat":54,"lon":53},[57],{"name":35,"role":36,"phone":58,"phoneExt":10,"email":59},"+49 152 2282 3999","t.brehm@uke.de",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Thomas Theo Brehm","Dr. med.","100602573","sputum-free-diagnostis-of-tb-100602573",false,"NCT07125274","Sputum-free Diagnostis of TB","Biomarker-guided Diagnosis of Tuberculosis","TB_Diagnostics","Inclusion Criteria:\n\n* Suspected pulmonary or extrapulmonary tuberculosis, or confirmed pulmonary or extrapulmonary tuberculosis with less than 7 days of anti-tuberculosis treatment, OR other pulmonary infection (control group).\n* Age ≥ 18 years\n* Ability to provide informed consent\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Lack of ability to provide informed consent\n* Age \\\u003C 18 years\n* Pregnancy","ALL","18 Years",{"count":75,"type":76},100,"ESTIMATED","OBSERVATIONAL","The aim of this study is to identify new biomarkers that enable reliable, non-invasive diagnosis of tuberculosis (TB), including in patients who are unable to produce sputum. The study analyzes biomaterials (blood, urine, stool, sputum) collected from patients with suspected TB. Various diagnostic methods are applied to assess the feasibility of individual and combined biomarker tests.\n\nParticipating patients will provide biomaterial samples (blood, urine, stool, sputum) once. No additional examinations or invasive procedures will be performed. Routine diagnostic procedures remain unaffected.\n\nThis is a single-center, prospective observational study. Patients are enrolled as part of their clinical care at the University Medical Center Hamburg-Eppendorf.",[80],"Tuberculosis",[82,83,84,85,86,87,88,89,90],"TB","diagnostics","sputum","sputum-free","transcriptomic","pathfast","CRISPR","stool","PCR","2025-08-12",{"date":93,"type":94},"2025-08-15","ACTUAL",{"date":96,"type":94},"2025-06-06",{"date":98,"type":76},"2026-12",{"name":5,"class":6},1]