[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529451":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":18,"centralContacts":22,"locations":27,"responsibleParty":44,"collaborators":7,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":7,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":7,"studyType":59,"phases":7,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":30,"whyStopped":7,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Nanfang Hospital, Southern Medical University","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DEVICE","FibroScan® Expert 630","The SSM by FibroScan 630 was first performed after admission, repeated at the day 5±2 as soon as feasible, and finally evaluated before discharge.",[14,15,16,17],"FibroScan® (FibroScan® expert 630 machine; Echosens, Paris, France)","Spleen mode (SSM@100 Hz)","Spleen vibration-controlled transient elastography (VCTE) settings (SSM@100 Hz)","Spleen-dedicated examination based on VCTE (SSM@100 Hz)",[19],{"name":20,"affiliation":5,"role":21},"Jinjun Chen, PHD","PRINCIPAL_INVESTIGATOR",[23],{"name":20,"role":24,"phone":25,"phoneExt":7,"email":26},"CONTACT","86-18588531001","chjj@smu.edu.cn",[28],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University","RECRUITING","Guangzhou","Guangdong","510515","China","CN",{"type":37,"coordinates":38},"Point",[39,40],113.25,23.11667,{"lat":40,"lon":39},[43],{"name":20,"role":24,"phone":25,"phoneExt":7,"email":26},{"type":45,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100529451","ssm-predicts-outcomes-of-cld-inpatients-with-acute-liver-injury-100529451",false,"NCT06173947","SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury","Spleen Stiffness Measurement Predicts Short-term Outcomes of Chronic Liver Disease Inpatients With Acute Liver Injury: a Prospective, Observational and Multicentre Study","Inclusion Criteria:\n\n1. Age between 18 years and 80 years\n2. Chronic liver diseases regardless of etiology\n3. Acute liver injury with total bilirubin ≥ 3 mg\u002Fdl regardless of inducement\n\nExclusion Criteria:\n\n1. Prior surgery of liver diseases before enrollment such as liver transplantation, transjugular intrahepatic portosystemic shunt (TIPS), splenectomy and partial splenic embolization\n2. Severe extrahepatic diseases such as chronic obstructive pulmonary disease level IV, chronic kidney disease with end-stage renal failure, myocardial infarction within 3 months before admission\n3. Receiving Immunosuppressive drugs for reasons rather than chronic liver diseases\n4. Diagnosis of hepatocellular carcinoma or other non-liver malignancies during screening period\n5. Serious mental illnesses such as anxiety, depressive disorders to obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD)\n6. The pregnant\n7. Jaundice due to biliary obstruction or cholestasis\n8. Unsuitable to participate in this study judging by investigators","ALL","18 Years","80 Years",{"count":57,"type":58},411,"ESTIMATED","OBSERVATIONAL","In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury. The present study aimed to establish an early diagnosis warning model for acute-on-chronic liver failure (ACLF) by SSM and investigate the effect of dynamic changes in SSM on the short-term prognosis (28-day, 90-day morbidity and mortality) of inpatients with CLD and acute liver injury.",[62,63,64,65],"End Stage Liver Disease","Jaundice","Liver Dysfunction","Portal Hypertension",[62,67,68,69,65,63],"Chronic Liver Disease","Spleen Stiffness Measurement","Acute-on-Chronic Liver Failure","2025-05-19",{"date":72,"type":73},"2025-05-21","ACTUAL",{"date":75,"type":73},"2024-01-01",{"date":77,"type":58},"2025-12-30",{"name":5,"class":6},1]