[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100501278":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":75,"collaborators":26,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":26,"eligibilityCriteria":83,"healthyVolunteers":80,"sex":84,"minAge":85,"maxAge":26,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":26,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Charite University, Berlin, Germany","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"LSA-1","EXPERIMENTAL","Light Scheduling Algorithm-1 (LSA-1): High circadian effective irradiances",[13],"Device: Dynamic Light Therapy Device, LSA-1",{"label":15,"type":16,"description":17,"interventionNames":18},"LSA-2","ACTIVE_COMPARATOR","Light Scheduling Algorithm-2 (LSA-2): Irradiance levels comparable to conventional hospital lighting (control group).",[19],"Device: Dynamic Light Therapy Device, LSA-2",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Dynamic Light Therapy Device, LSA-1","Dynamic Light Therapy",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Dynamic Light Therapy Device, LSA-2","Light Exposition",[15],[32],{"name":33,"affiliation":5,"role":34},"Claudia Spies, MD, Prof.","STUDY_DIRECTOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+49 30 450 55 11 02","claudia.spies@charite.de",[41,61],{"facility":42,"status":43,"city":44,"state":26,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Department of Anesthesiology and Intensive Care Medicine (CCM\u002FCVK), Campus Charité Mitte","RECRUITING","Berlin","10117","Germany","DE",{"type":49,"coordinates":50},"Point",[51,52],13.41053,52.52437,{"lat":52,"lon":51},[55,56,58],{"name":33,"role":37,"phone":26,"phoneExt":26,"email":26},{"name":33,"role":57,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":59,"role":60,"phone":26,"phoneExt":26,"email":26},"Alawi Lütz, MD, Prof.","SUB_INVESTIGATOR",{"facility":62,"status":43,"city":44,"state":26,"zip":63,"country":46,"countryCode":47,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Department of Anesthesiology and Intensive Care Medicine (CCM\u002FCVK), Campus Virchow Klinikum","13353",{"type":49,"coordinates":65},[51,52],{"lat":52,"lon":51},[68,69,71,73],{"name":33,"role":37,"phone":26,"phoneExt":26,"email":26},{"name":70,"role":57,"phone":26,"phoneExt":26,"email":26},"Claudia Spies, MD,Prof.",{"name":72,"role":60,"phone":26,"phoneExt":26,"email":26},"Lilian Jo Engelhardt, MD",{"name":74,"role":60,"phone":26,"phoneExt":26,"email":26},"Henry A Orlovsky",{"type":57,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Claudia Spies","Head of the Department of Anesthesiology and Intensive Care Medicine (CCM\u002FCVK)","100501278","stabilization-of-circadian-rhythms-in-delirious-icu-patients-through-light-intervention-100501278",false,"NCT05807178","Stabilization of Circadian Rhythms in Delirious ICU Patients Through Light Intervention","Inclusion Criteria:\n\n* Patient capable of giving consent or additionally existing legal caregiver or authorized\u002Fspouse representative in case of non-consenting patients in the intensive care unit\n* Male and female patients with age ≥ 18 years\n* Expected intensive care unit stay ≥ 2 days\n* Positive delirium during and up to a maximum of 30 days after study inclusion (determined by CAM-ICU, at least once per shift)\n\nExclusion Criteria:\n\n* Participation in other clinical studies during the study period and ten days before\n* Previous ICU treatment during the current hospital stay\n* Patients with psychiatric diseases\n* Patients with a history of stroke and known severe residual cognitive deficits\n* Patients with a history of cardiopulmonary arrest or pulseless electric activity with cardiopulmonary resuscitation followed by therapeutic hypothermia during entire hospital stay\n* Amaurosis\n* History of sleep-related breathing disorders\n* History or suspicion of hypoxic brain damage\n* History or suspicion of elevated intracranial pressure in the last 7 days before study inclusion\n* Patient has a power of attorney or patient's provision, where he\u002Fshe refuses participation in any clinical trial\n* The informed consent of the patient or the subject's legally acceptable representative can't be obtained in time\n* History of photoallergic reactions or history of visually triggered seizures\n* Severe eye diseases (e.g. retinopathy, glaucoma) or high sensitivity to bright light\n* Patients with liver cirrhosis\n* Patients with a probability of survival \\\u003C24h\n* Optic neuritis within the last 3 months\n* Travel across two time zones within 3 months prior to study screening\n* Women who are pregnant, have a positive pregnancy test, are breastfeeding or plan to become pregnant during the course of this clinical trial\n* Therapy-refractory blood coagulation disorder and inability to consent are exclusion criteria for a muscle biopsy","ALL","18 Years",{"count":87,"type":88},40,"ESTIMATED","INTERVENTIONAL",[91],"NA","The investigators will examine the effects of dynamic light therapy on circadian rhythms in delirious intensive care unit (ICU) patients. In a randomized controlled trial (RCT), they will investigate the effects of a specific light algorithm on rhythms of serum melatonin, clock gene expression, the proteome, and metabolome, compared to standard hospital lighting, supported by the data science algorithms to improve vital-based algorithms with light interventions.",[94],"Circadian Dysrhythmia","2026-01-22",{"date":97,"type":98},"2026-01-23","ACTUAL",{"date":100,"type":98},"2026-01-20",{"date":102,"type":88},"2027-09-30",{"name":5,"class":6},2]