[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594537":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":33,"locations":43,"responsibleParty":65,"collaborators":32,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":32,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":32,"overallStatus":46,"whyStopped":32,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Illinois at Urbana-Champaign","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IAAO","EXPERIMENTAL","Participants will ingest a series of 6 hourly beverages containing 50% of the daily intake of 1.1g\u002Fkg\u002Fday",[13],"Procedure: Indispensable Amino Acid Oxidation",{"label":15,"type":10,"description":16,"interventionNames":17},"SIOGTT","Participants will consume one 75g glucose drink dissolved in 250 ml of water.",[18],"Procedure: Stable Isotope Oral Glucose Tolerance Test",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Indispensable Amino Acid Oxidation","Participants will ingest six hourly meals designed to provide 50% of the daily intake of 1.1 g·kgLBM. Additional energy (1.5x daily resting metabolic rate), carbohydrate (55%), and fat (35%) will be provided in beverages and protein-free cookies (for palatability). The first drink will contain priming doses of NaH13CO2 (0.176 mg·kg-1), \\[13C\\]phenylalanine (1.86 mg·kg-1), \\[2H5\\]phenylalanine (0.34 mg·kg-1) with all subsequent drinks containing 1.2 mg·kg-1 \\[13C\\]phenylalanine and 0.51 mg·kg-1 \\[2H5\\]phenylalanine.",[9],[9],{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Stable Isotope Oral Glucose Tolerance Test","Participants will consume a 75g glucose drink dissolved in 250 ml of water enriched with \\[6,6\\_2H2\\]glucose and \\[13C6\\]glucose.",[15],[31],"Si OGTT",null,[34,39],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},"Nicholas Burd (Associate Professor), PhD","CONTACT","2172440970","naburd@illinois.edu",{"name":40,"role":36,"phone":41,"phoneExt":32,"email":42},"Gena L Irwin (Research Assistant), M.S","3608883281","genai2@illinois.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Freer Hall - University of Illinois","RECRUITING","Urbana","Illinois","61801","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-88.20727,40.11059,{"lat":56,"lon":55},[59,60,62],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},{"name":61,"role":36,"phone":41,"phoneExt":32,"email":42},"Gena L Irwin Research Assistant, M.S",{"name":63,"role":64,"phone":32,"phoneExt":32,"email":32},"Nicholas Burd, PhD","PRINCIPAL_INVESTIGATOR",{"type":66,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100594537","stable-isotopes--adults-with-obesity-100594537",false,"NCT07020741","Stable Isotopes- Adults With Obesity","Assessing Metabolic Health With Stable Isotope Tracer Techniques in Adults With Obesity","Si-OBA","Inclusion Criteria:\n\n* ages 19-59\n* Obese \\>\u002F= 30 kg\u002Fm\\^2 and \\>\u002F= 102 cm for males and \\>\u002F= 88 cm for females\n* Godin Leisure-time or exercise questionnaire \\\u003C14 units\n\nExclusion Criteria:\n\n1. Pregnant or become pregnant\n2. Any known food allergies\n3. Smoker\n4. Are physically active\n5. Have any known metabolic diseases\n6. Have been weight unstable within the last 6 months (lost or gained \\>10% of body mass)\n7. Non eumenorrheic or on a hormonal birth control",true,"ALL","19 Years","59 Years",{"count":80,"type":81},8,"ESTIMATED","INTERVENTIONAL",[84],"NA","In a crossover design, 8 participants will receive caloric drinks containing stable isotopes. In one arm of the study, participants will consume 6 hourly drinks containing two stable isotopes. Repeated blood, breath, urine, and muscle biopsies will be taken. In the second arm, participants will consume 1 drink containing 75g glucose, labeled with two stable isotopes of glucose. Periodic blood and breath will be taken over three hours.",[87,88,89],"Obese Patients (BMI ≥ 30 kg\u002Fm²)","Glucose Metabolism","Protein Metabolism","2026-04-28",{"date":92,"type":93},"2026-04-29","ACTUAL",{"date":95,"type":93},"2025-09-12",{"date":97,"type":81},"2026-12-31",{"name":5,"class":6},1]