[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644699":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":38,"locations":25,"responsibleParty":49,"collaborators":52,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":25,"maxAge":25,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":80,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":25},{"fullName":5,"class":6},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Traditional RFA","ACTIVE_COMPARATOR","Participants randomized to this arm will receive the standard 3-target knee RFA protocol as part of their standard clinical care.",[13],"Procedure: Radiofrequency ablation - 3-target technique",{"label":15,"type":10,"description":16,"interventionNames":17},"Novel RFA","Participants randomized to this arm will receive the 6-target knee RFA protocol as part of their standard clinical care.",[18],"Procedure: Radiofrequency ablation - 6-target technique",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Radiofrequency ablation - 3-target technique","X-ray imaging is used to guide needles that target the superior lateral, superior medial, and inferior medial genicular nerves surrounding the knee, heat is used to ablate the nerves.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Radiofrequency ablation - 6-target technique","X-ray imaging is used to guide needle placement for radiofrequency ablation targeting the superior lateral, superior medial, and inferior medial genicular nerve regions around the knee. The 6-target protocol also includes supplementary ablation lesions at three additional target sites around the knee. These additional targets are treated by adjusting the needle angle once inserted, without requiring additional needle insertions beyond the standard approach.",[15],[31,35],{"name":32,"affiliation":33,"role":34},"Eldon Loh, MD","Lawson Health Research Institute of St. Joseph's","STUDY_CHAIR",{"name":36,"affiliation":33,"role":37},"John Tran, PhD","PRINCIPAL_INVESTIGATOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Melissa Calleja, MSc","CONTACT","519-646-6100","42208","melissa.calleja@sjhc.london.on.ca",{"name":46,"role":41,"phone":42,"phoneExt":47,"email":48},"Arden Lawson, MSc","42570","arden.lawson@sjhc.london.on.ca",{"type":37,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"John Tran","Principal Investigator, PhD",[53,55],{"name":54,"class":6},"Western University",{"name":56,"class":6},"St. Joseph's Health Care London","100644699","standard-versus-novel-rfa-for-chronic-knee-pain-in-osteoarthritis-100644699",false,"NCT07674082","Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis","A Prospective Pilot Study Comparing Standard and Novel Radiofrequency Ablation Protocols for Chronic Knee Pain in Osteoarthritis","Inclusion Criteria:\n\n1. Any patient with knee osteoarthritis receiving knee RFA.\n2. Stable pain medications for past 1 month.\n3. Able to speak English.\n\nExclusion Criteria:\n\n1. Scheduled for knee surgery within 6 months following RFA procedure.\n2. Participating in another study that the Principal Investigator or Co-Investigators deem will interfere with the interpretation of the results.","ALL",{"count":66,"type":67},24,"ESTIMATED","INTERVENTIONAL",[70],"NA","Brief Summary\n\nThe goal of this pilot study is to evaluate the feasibility and safety of conducting a randomized comparison of two standard-of-care knee radiofrequency ablation (RFA) techniques in adults with chronic knee pain related to knee osteoarthritis.\n\nParticipants who are already scheduled to receive knee RFA as part of their standard clinical care will be randomized to receive either a standard 3-target (standard) RFA protocol or a 6-target (novel) RFA protocol. The main purpose of this pilot study is to determine whether a future larger randomized trial comparing these two RFA approaches is feasible and safe to conduct.\n\nParticipants will complete questionnaires about pain, knee function, and stiffness at baseline and at follow-up timepoints for up to 12 months after the RFA procedure. Preliminary pain relief outcomes will also be explored to help inform the design of a future definitive trial.\n\nParticipants already scheduled for a knee RFA procedure as part of their standard of care for pain related to knee osteoarthritis will answer online survey questions about their pain for up to 12 months.",[73],"Osteoarthritis, Knee",[75,76,77,78,79],"radiofrequency ablation","radiofrequency","needle insertion","knee pain","pain management","NOT_YET_RECRUITING","2026-06-23",{"date":83,"type":84},"2026-06-29","ACTUAL",{"date":86,"type":67},"2026-07-20",{"date":88,"type":67},"2029-08-20",{"name":90,"class":6},"Lawson Research Institute of St. Joseph's"]