[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627110":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":444,"collaborators":26,"id":446,"slug":447,"hasResults":448,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":452,"eligibilityCriteria":453,"healthyVolunteers":448,"sex":454,"minAge":455,"maxAge":456,"enrollmentInfo":457,"targetDuration":26,"studyType":460,"phases":461,"briefSummary":463,"conditions":464,"keywords":471,"overallStatus":60,"whyStopped":26,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":486},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"CPAP Group","EXPERIMENTAL","Usual care combined with CPAP therapy.",[13,14],"Device: Continuous Positive Airway Pressure (CPAP)","Other: Usual Care",{"label":16,"type":17,"description":18,"interventionNames":19},"Usual Care Group","ACTIVE_COMPARATOR","Standard of care for atrial fibrillation and usual care for OSA (health education). Researchers advise participants to visit sleep centers or pulmonology departments for further assessment\u002Ftreatment at their own discretion, but do not intervene in their choice of OSA therapy or provide the study CPAP device.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Continuous Positive Airway Pressure (CPAP)","Participants receive CPAP therapy provided by the research team. Treatment parameters are determined following auto-titrating or manual pressure titration. Prior to treatment initiation, participants receive training on device usage, mask fitting and adjustment, equipment cleaning and maintenance, and data transmission methods. Study physicians and technicians provide support to address any CPAP-related discomfort. 'Good adherence' is defined as device usage of ≥ 4 hours per night on ≥ 70% of days.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Usual Care","Participants receive standardized medical therapy for atrial fibrillation in accordance with international guidelines and clinical routine. For OSA management, researchers provide standardized health education. This includes informing participants about the risks associated with OSA and advising on lifestyle modifications, including weight loss, adopting a lateral sleeping position, and avoiding alcohol and sedatives.",[9,16],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Jiang Xie, Professor","CONTACT","+86 64456360","frank782008@aliyun.com",[38,59,72,84,96,108,124,136,151,167,183,198,213,229,246,262,274,290,306,322,338,353,365,381,396,412,428],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Beijing Chaoyang Hospital, Capital Medical University","NOT_YET_RECRUITING","Beijing","Beijing Municipality","100020","China","CN",{"type":47,"coordinates":48},"Point",[49,50],116.39723,39.9075,{"lat":50,"lon":49},[53,57],{"name":54,"role":34,"phone":55,"phoneExt":26,"email":56},"Zhiling Zhao, 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01058516688","hengyang0323@outlook.com",{"name":80,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":85,"status":40,"city":41,"state":42,"zip":86,"country":44,"countryCode":45,"cosmosGeoPoint":87,"geoPoint":89,"contacts":90},"Beijing Hospital","100730",{"type":47,"coordinates":88},[49,50],{"lat":50,"lon":49},[91,95],{"name":92,"role":34,"phone":93,"phoneExt":26,"email":94},"Wei Gong, Professor","+86 85132266","gongwei5180@bjhmoh.cn",{"name":92,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":97,"status":40,"city":41,"state":42,"zip":98,"country":44,"countryCode":45,"cosmosGeoPoint":99,"geoPoint":101,"contacts":102},"Peking University International Hospital","102206",{"type":47,"coordinates":100},[49,50],{"lat":50,"lon":49},[103,107],{"name":104,"role":34,"phone":105,"phoneExt":26,"email":106},"Xuezhi Chen, Professor","+86 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059187981698","1533532863@qq.com",{"name":132,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":137,"status":40,"city":138,"state":111,"zip":139,"country":44,"countryCode":45,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"Zhangzhou Hospital of Fujian Province","Zhangzhou","363000",{"type":47,"coordinates":141},[142,143],117.65556,24.51333,{"lat":143,"lon":142},[146,150],{"name":147,"role":34,"phone":148,"phoneExt":26,"email":149},"Lida Chen, Professor","+86-596-2082000","361328175@qq.com",{"name":147,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":152,"status":40,"city":153,"state":154,"zip":155,"country":44,"countryCode":45,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"People's Hospital of Guangxi Zhuang Autonomous Region","Nanning","Guangxi","530021",{"type":47,"coordinates":157},[158,159],108.31667,22.81667,{"lat":159,"lon":158},[162,166],{"name":163,"role":34,"phone":164,"phoneExt":26,"email":165},"Mingming Zhao, 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Medicine","Shijiazhuang","050000",{"type":47,"coordinates":188},[189,190],114.47861,38.04139,{"lat":190,"lon":189},[193,197],{"name":194,"role":34,"phone":195,"phoneExt":26,"email":196},"Linyi Huang, Professor","+86-0311-85837801","496777551@qq.com",{"name":194,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":199,"status":40,"city":200,"state":170,"zip":201,"country":44,"countryCode":45,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"The Ninth Hospital of Xingtai","Xingtai","055250",{"type":47,"coordinates":203},[204,205],114.49272,37.06217,{"lat":205,"lon":204},[208,212],{"name":209,"role":34,"phone":210,"phoneExt":26,"email":211},"Zunshou Li, Professor","+86-0319-4321827","julu2011.@126.com",{"name":209,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":214,"status":40,"city":215,"state":216,"zip":217,"country":44,"countryCode":45,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"Second Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang","150086",{"type":47,"coordinates":219},[220,221],126.65,45.75,{"lat":221,"lon":220},[224,228],{"name":225,"role":34,"phone":226,"phoneExt":26,"email":227},"Shuo Zhang, Professor","+86 045186296870","zhangshuoemail@163.com",{"name":225,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":230,"status":40,"city":231,"state":232,"zip":233,"country":44,"countryCode":45,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"The First Affiliated Hospital of Zhengzhou University","Zhengzhou","Henan","450052",{"type":47,"coordinates":235},[236,237],113.64861,34.75778,{"lat":237,"lon":236},[240,244],{"name":241,"role":34,"phone":242,"phoneExt":26,"email":243},"Songyun Ouyang","+86-371-66913114","ouyangsy@163.com",{"name":245,"role":58,"phone":26,"phoneExt":26,"email":26},"Songyun Ouyang, Professor",{"facility":247,"status":40,"city":248,"state":249,"zip":250,"country":44,"countryCode":45,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Wuhan No. 1 Hospital","Wuhan","Hubei","430014",{"type":47,"coordinates":252},[253,254],114.26667,30.58333,{"lat":254,"lon":253},[257,261],{"name":258,"role":34,"phone":259,"phoneExt":26,"email":260},"Junhua Mei, Professor","+86 02785332144","xiaomeijh@163.com",{"name":258,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":263,"status":40,"city":248,"state":249,"zip":264,"country":44,"countryCode":45,"cosmosGeoPoint":265,"geoPoint":267,"contacts":268},"Wuhan Asia General Hospital","430056",{"type":47,"coordinates":266},[253,254],{"lat":254,"lon":253},[269,273],{"name":270,"role":34,"phone":271,"phoneExt":26,"email":272},"Ning Man, Professor","+86-027-84788999","Mannyl75@126.com",{"name":270,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":275,"status":40,"city":276,"state":277,"zip":278,"country":44,"countryCode":45,"cosmosGeoPoint":279,"geoPoint":283,"contacts":284},"The Second Xiangya Hospital of Central South University","Changsha","Hunan","410011",{"type":47,"coordinates":280},[281,282],112.97087,28.19874,{"lat":282,"lon":281},[285,289],{"name":286,"role":34,"phone":287,"phoneExt":26,"email":288},"Ruoyun Ouyang, Professor","+86-731-85295888","ouyangruoyun@csu.edu.cn",{"name":286,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":291,"status":40,"city":292,"state":293,"zip":294,"country":44,"countryCode":45,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"The First Affiliated Hospital of Nanjing Medical University","Nanjing","Jiangsu","210029",{"type":47,"coordinates":296},[297,298],118.77778,32.06167,{"lat":298,"lon":297},[301,305],{"name":302,"role":34,"phone":303,"phoneExt":26,"email":304},"Ning Ding, Professor","+86 02568307346","dingning@njmu.edu.cn",{"name":302,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":307,"status":40,"city":308,"state":309,"zip":310,"country":44,"countryCode":45,"cosmosGeoPoint":311,"geoPoint":315,"contacts":316},"The First Hospital of Jilin University","Changchun","Jilin","130021",{"type":47,"coordinates":312},[313,314],125.32278,43.88,{"lat":314,"lon":313},[317,321],{"name":318,"role":34,"phone":319,"phoneExt":26,"email":320},"Haibo Yuan, Professor","+86-431-88782222","hyuan@jlu.edu.cn",{"name":318,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":323,"status":40,"city":324,"state":325,"zip":326,"country":44,"countryCode":45,"cosmosGeoPoint":327,"geoPoint":331,"contacts":332},"First Affiliated Hospital of Dalian Medical University","Dalian","Liaoning","116011",{"type":47,"coordinates":328},[329,330],121.60222,38.91222,{"lat":330,"lon":329},[333,337],{"name":334,"role":34,"phone":335,"phoneExt":26,"email":336},"Haiying Tang, Professor","+86 0411836359632561","doctortanghy@163.com",{"name":334,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":339,"status":40,"city":340,"state":325,"zip":341,"country":44,"countryCode":45,"cosmosGeoPoint":342,"geoPoint":346,"contacts":347},"First Affiliated Hospital of China Medical University","Shenyang","110001",{"type":47,"coordinates":343},[344,345],123.43278,41.79222,{"lat":345,"lon":344},[348,352],{"name":349,"role":34,"phone":350,"phoneExt":26,"email":351},"Wenyang Li, Professor","+86 83282530","20122043@cmu.edu.cn",{"name":349,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":354,"status":40,"city":340,"state":325,"zip":355,"country":44,"countryCode":45,"cosmosGeoPoint":356,"geoPoint":358,"contacts":359},"Shengjing Hospital of China Medical University","110004",{"type":47,"coordinates":357},[344,345],{"lat":345,"lon":344},[360,364],{"name":361,"role":34,"phone":362,"phoneExt":26,"email":363},"Li Xiao, Professor","+86-24-96615","xiaolisy@163.com",{"name":361,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":366,"status":40,"city":367,"state":368,"zip":369,"country":44,"countryCode":45,"cosmosGeoPoint":370,"geoPoint":374,"contacts":375},"Shengli Oilfield Central Hospital","Dongying","Shandong","257034",{"type":47,"coordinates":371},[372,373],118.49165,37.46271,{"lat":373,"lon":372},[376,380],{"name":377,"role":34,"phone":378,"phoneExt":26,"email":379},"Xingliang Hao, Professor","+86-546-8551222","haoxingliang1980@163.com",{"name":377,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":382,"status":40,"city":383,"state":368,"zip":384,"country":44,"countryCode":45,"cosmosGeoPoint":385,"geoPoint":389,"contacts":390},"Linyi People's Hospital","Linyi","276003",{"type":47,"coordinates":386},[387,388],118.34278,35.06306,{"lat":388,"lon":387},[391,395],{"name":392,"role":34,"phone":393,"phoneExt":26,"email":394},"Li Wei, Professor","+86-539-8216261","weilineu@163.com",{"name":392,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":397,"status":40,"city":398,"state":399,"zip":400,"country":44,"countryCode":45,"cosmosGeoPoint":401,"geoPoint":405,"contacts":406},"Second Hospital of Shanxi Medical University","Taiyuan","Shanxi","030001",{"type":47,"coordinates":402},[403,404],112.56028,37.86944,{"lat":404,"lon":403},[407,411],{"name":408,"role":34,"phone":409,"phoneExt":26,"email":410},"Xiaoling Gao, Professor","+86 03513362858","yihexiyuan@qq.com",{"name":408,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":413,"status":40,"city":414,"state":415,"zip":416,"country":44,"countryCode":45,"cosmosGeoPoint":417,"geoPoint":421,"contacts":422},"Tianjin Chest Hospital","Tianjin","Tianjin Municipality","300222",{"type":47,"coordinates":418},[419,420],117.17667,39.14222,{"lat":420,"lon":419},[423,427],{"name":424,"role":34,"phone":425,"phoneExt":26,"email":426},"Xiaoyun Zhao, Professor","+86-22-88185111","zxydoctor@163.com",{"name":424,"role":58,"phone":26,"phoneExt":26,"email":26},{"facility":429,"status":40,"city":430,"state":431,"zip":432,"country":44,"countryCode":45,"cosmosGeoPoint":433,"geoPoint":437,"contacts":438},"First Affiliated Hospital of Ningbo University","Ningbo","Zhejiang","315010",{"type":47,"coordinates":434},[435,436],121.54945,29.87819,{"lat":436,"lon":435},[439,443],{"name":440,"role":34,"phone":441,"phoneExt":26,"email":442},"Maoqing Tong, Professor","+86 57487085588","ganbaursy@163.com",{"name":440,"role":58,"phone":26,"phoneExt":26,"email":26},{"type":445,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100627110","start-cpap-therapy-in-obstructive-sleep-apnea-patients-after-atrial-fibrillation-ablation-100627110",false,"NCT07444372","Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation","Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation: A Multicenter, Open-label, Randomized Clinical Trial","STOP-AFib","Inclusion Criteria:\n\nPatients must meet all of the following conditions to be eligible for the study:\n\n* Age 18-75 years.\n* Patients with persistent AF scheduled for first-time catheter ablation.\n* Diagnosed with OSA.\n* Able to tolerate CPAP therapy.\n* Capable of understanding and complying with the study protocol.\n* Willing to sign the informed consent form.\n\nExclusion Criteria:\n\nPatients meeting any of the following criteria will be excluded from the study:\n\n* Secondary AF.\n* Left atrial anteroposterior diameter 60mm (measured via parasternal long-axis view).\n* Left ventricular ejection fraction \\\u003C 30%.\n* Comorbid moderate-to-severe mitral stenosis or history of prosthetic valve replacement (mechanical or bioprosthetic).\n* Pregnant or breastfeeding women.\n* History of myocardial infarction, percutaneous coronary intervention, or cardiac surgery within 3 months prior to screening.\n* History of stroke or transient ischemic attack within 6 months prior to screening.\n* Perioperative complications related to the ablation procedure occurring prior to randomization.\n* Inability to discontinue antiarrhythmic drugs (AADs) post-procedure due to other reasons.\n* Life expectancy \\\u003C 1 year.\n* Central sleep apnea.\n* Conditions requiring ventilatory support, including obesity hypoventilation syndrome (defined as BMI \\> 30kg\u002Fm² and awake PaCO₂ \\> 45mmHg), amyotrophic lateral sclerosis, or chronic obstructive pulmonary disease with \\> 1 episode of respiratory failure or hypercapnia.\n* Treatment-emergent central sleep apnea during CPAP tolerance assessment that cannot be corrected prior to randomization.\n* Receipt of instrumental or surgical treatment for OSA within 3 months prior to screening, including CPAP, oral appliances, ENT surgery, or bariatric surgery.\n* Use of glucagon-like peptide-1 receptor agonists, glucose-dependent insulinotropic peptide receptor agonists, or glucagon receptor agonists for weight loss within 3 months prior to screening, or plans to initiate such medications within the next year.\n* Current participation in other drug or device trials.","ALL","18 Years","75 Years",{"count":458,"type":459},658,"ESTIMATED","INTERVENTIONAL",[462],"NA","Atrial fibrillation (AF) is one of the most common clinical arrhythmias. Catheter ablation is an effective therapeutic strategy; however, recurrence rates remain substantial, ranging from 20% to 45%. Previous studies have established a strong association between obstructive sleep apnea (OSA) and the risk of AF recurrence following ablation. While continuous positive airway pressure (CPAP) is the standard intervention for OSA, and some observational studies suggest it may reduce post-ablation recurrence in patients with comorbid OSA, small randomized controlled trials have failed to confirm a clear benefit, potentially due to poor adherence.\n\nThis study aims to evaluate the clinical benefit of post-ablation CPAP therapy in AF patients with comorbid OSA.\n\nParticipants will:\n\n* Be randomly assigned to either the CPAP group or the usual care group.\n* If in the CPAP group, use a CPAP device for 12 months.\n* Wear an ambulatory ECG recorder for a 7-day period at 3, 6, 9, and 12 months post-operation.\n* Complete follow-up checkups either at the clinic or over the phone at 1, 3, 6, and 12 months after their procedure.",[465,466,467,468,469,470],"Obstructive Sleep Apnea","Sleep Disorder (Disorder)","Atrial Fibrillation (AF)","Sleep Disordered Breathing (SDB)","Arrhythmia","Continuous Positive Airway Pressure",[465,470,472,473,474,475,476],"Atrial Fibrillation","Ablation of atrial fibrillation","Sleep Disordered Breathing","Clinical Trial","Catheter Ablation","2026-06-14",{"date":479,"type":480},"2026-06-16","ACTUAL",{"date":482,"type":480},"2026-05-12",{"date":484,"type":459},"2029-01-31",{"name":5,"class":6},27]