[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100499762":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":50,"centralContacts":55,"locations":61,"responsibleParty":77,"collaborators":80,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":10,"studyType":98,"phases":10,"briefSummary":99,"conditions":100,"keywords":10,"overallStatus":63,"whyStopped":10,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,15,19,23,27,31],{"label":9,"type":10,"description":11,"interventionNames":12},"Cis Man",null,"Person assigned male at birth and whose gender identity is man.",[13,14],"Behavioral: Quantative sensory testing","Diagnostic Test: Blood Draw",{"label":16,"type":10,"description":17,"interventionNames":18},"Cis Woman","Person assigned female at birth and whose gender identity is woman.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Transgender Man","Person assigned female at birth and whose gender identity is man.",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Transgender Woman","Person assigned male at birth and whose gender identity is woman.",[13,14],{"label":28,"type":10,"description":29,"interventionNames":30},"Transgender Man plus Testosterone","Person assigned female at birth and whose gender identity is man and are currently on testosterone replacement.",[13,14],{"label":32,"type":10,"description":33,"interventionNames":34},"Transgender Woman plus Estrogen","Person assigned male at birth and whose gender identity is woman and are currently on estrogen replacement.",[13,14],[36,43],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"BEHAVIORAL","Quantative sensory testing","All participants will undergo quantitative sensory testing for assessment of endogenous pain modulation using painful heat, mechanical, and cold stimuli in a laboratory session lasting approximately 1 hour.",[9,16,20,28,24,32],[42],"QST",{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"DIAGNOSTIC_TEST","Blood Draw","Sample of blood will be taken.",[9,16,20,28,24,32],[49],"Venipuncture",[51],{"name":52,"affiliation":53,"role":54},"Robert Sorge, Phd","University of Alabama at Birmingham Department of Psychology","PRINCIPAL_INVESTIGATOR",[56],{"name":57,"role":58,"phone":59,"phoneExt":10,"email":60},"Tammie Quinn, BA","CONTACT","(205) 934-8743","tquinn@uab.edu",[62],{"facility":5,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":70,"coordinates":71},"Point",[72,73],-86.80249,33.52066,{"lat":73,"lon":72},[76],{"name":57,"role":58,"phone":59,"phoneExt":10,"email":60},{"type":54,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Robert Sorge","Associate Professor",[81],{"name":82,"class":83},"National Institute of Nursing Research (NINR)","NIH","100499762","state-of-hormones-impact-nociceptive-expression-100499762",false,"NCT05787470","State of Hormones Impact Nociceptive Expression","SHINE","Inclusion Criteria:\n\n* self-identification as one of the above gender identities\n* understanding of verbal and written English.\n* participants that have been on\u002Foff hormone treatment for at least 6 months\n\nExclusion Criteria:\n\n* pain in at least 3\u002F7 days\u002Fweek for the past 3 months\n* HIV positive diagnosis\n* cardiovascular or pulmonary disease\n* regular use of opioid pain medications\n* uncontrolled hypertension (i.e. SBP\u002FDBP of \\> 150\u002F95)\n* current illness accompanied by fever (body temperature \\>38 °C)\n* prostatectomy, hysterectomy or oophorectomy\n* hospitalization due to psychiatric illness within the last 6 months.",true,"ALL","18 Years","65 Years",{"count":96,"type":97},120,"ESTIMATED","OBSERVATIONAL","The Investigators have recently published on differences in pain sensitivity measures between cis and trans individuals in the local area. The investigators observed the anticipated differences in pain sensitivity between CM and CW (CW \\> CM), but found that the TW were phenotypically similar to CW in all measures. However, the investigators did not assess hormone level, nor did the investigators recruit TM participants. Here, with the assistance of two local community group stakeholders the investigators will recruit the following groups: CM, CW, TM+T (currently taking exogenous testosterone), TW+E (exogenous estradiol), TM, and TW (n=20\u002Fgroup). The investigators will use quantitative sensory testing to assess sensitivity to cold, pressure, and heat via standardized protocols. Blood samples will be taken for assessment of stress and reproductive hormone levels, immune cell populations and stimulated cytokine release. Finally, questionnaires will measure pain state, quality of life (QOL), voice QOL, body image, appearance, self-reported health, masculinity\u002Ffemininity, community connectedness, gender role, sleep, depression, social support, adverse childhood experiences and stigma.",[101,102],"Pain","Gender Identity","2026-07-01",{"date":105,"type":106},"2026-07-02","ACTUAL",{"date":108,"type":106},"2023-03-01",{"date":110,"type":97},"2027-07-31",{"name":5,"class":6},1]