[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575693":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":29,"centralContacts":34,"locations":28,"responsibleParty":44,"collaborators":28,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":28,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":28,"enrollmentInfo":57,"targetDuration":28,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":70,"whyStopped":28,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":28},{"fullName":5,"class":6},"Western University, Canada","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Type-2 Diabetes","EXPERIMENTAL","Cells are harvested from individuals with Type-2 Diabetes",[13],"Procedure: Hip Replacement",{"label":15,"type":10,"description":16,"interventionNames":17},"Obesity","Cells are Harvested from individuals with obesity",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Non-Type-2 Diabetic and Non-Obese Controls","Cells are harvested from individuals with no Type-2 Diabetes and no Obesity",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","Hip Replacement","Total Hip Arthroplasty where the Femoral Head will be used to harvest stem cells post-extrication from the individual.",[19,15,9],null,[30],{"name":31,"affiliation":32,"role":33},"David A Hess, PhD","Western University","PRINCIPAL_INVESTIGATOR",[35,40],{"name":31,"role":36,"phone":37,"phoneExt":38,"email":39},"CONTACT","519.931.5777","24118","dhess3@uwo.ca",{"name":41,"role":36,"phone":42,"phoneExt":28,"email":43},"Caleb J Podgers","343-364-4014","cpodgers@uwo.ca",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"SPONSOR_INVESTIGATOR","David Hess","Dr. David Hess","100575693","stem-cell-isolation-from-femoral-heads-post-total-hip-arthroplasty-100575693",false,"NCT06775600","Stem Cell Isolation From Femoral Heads Post Total Hip Arthroplasty","Harvest of Human Bone Marrow-Derived Progenitor Cells During Total Hip Arthroplasty for Use in Regenerative Medicine Applications for Blood Vessel and Islet Regeneration.","Inclusion Criteria:\n\n* Must be 18+ years of age\n\nExclusion Criteria:\n\n* Diagnosis of bone cancers\n* Diagnosis of Rheumatoid arthritis\n* Diagnosis of hematopoietic conditions\n* Diagnosis of avascular necrosis of the hip\n* does not fall within BMI requirements for experimental groups\n* Cannot read and\u002For speak in english","ALL","18 Years",{"count":58,"type":59},30,"ESTIMATED","INTERVENTIONAL",[62],"NA","Femoral heads will be collected at University Hospital (London, ON, Canada) from individuals with type-2 diabetes, obesity, and no T2D\u002Fno obesity controls. The femoral head will be taken to the Robarts Research Institute (London, ON, Canada) for lineage-restricted progenitor cell expansion and analyses. There the femoral heads will be used to isolate three stem cell types - Multipotent Stromal Cells, Endothelial Colony Forming Cells, and Hematopoietic Progenitor Cells. The yield and cell surface markers expressed on these cells will be measured using flow cytometry. These cell types will then undergo further analyses of the secretome, tubule forming assays, vascular regenerative cell exhaustion assays, and will be transplanted into immune deficient mice with with femoral artery ligation. These experiments are to assess the differences in function and expression of these cell types between individuals with type-2 diabetes and\u002For obesity and\u002For healthy controls.",[65],"Obesity and Type 2 Diabetes",[67,68,15,69],"Stem Cell","Diabetes","Regeneration","NOT_YET_RECRUITING","2025-01-14",{"date":73,"type":74},"2025-01-15","ACTUAL",{"date":76,"type":59},"2025-02-01",{"date":78,"type":59},"2025-08-01",{"name":46,"class":6}]