[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100422060":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":34,"centralContacts":42,"locations":51,"responsibleParty":80,"collaborators":11,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":86,"sex":92,"minAge":93,"maxAge":11,"enrollmentInfo":94,"targetDuration":11,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":54,"whyStopped":11,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Rigshospitalet, Denmark","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"PCI standard","ACTIVE_COMPARATOR",null,[13],"Procedure: PCI + Ischemic conditioning",{"label":15,"type":16,"description":11,"interventionNames":17},"PCI standard + ischemic conditioning","EXPERIMENTAL",[13],{"label":19,"type":16,"description":11,"interventionNames":20},"Stent with ultrasound",[21],"Procedure: Stent with ultrasound",{"label":23,"type":10,"description":11,"interventionNames":24},"Stent without ultrasound",[21],[26,31],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"PROCEDURE","PCI + Ischemic conditioning","IPOST is repeated for 4 cycles (60 sec obstruction followed by 60 sec perfusion each) and followed by stent implantation with a 1.1\u002F1.0 ratio of stent diameter\u002Freference vessel diameter and a stent length sufficient to cover the entire lesion from healthy to healthy area of the vessel. During the first cycle of re-occlusion of full vessel occlusion is secured by a small injection of contrast.",[9,15],{"type":27,"name":19,"description":32,"armGroupLabels":33,"otherNames":11},"IVUS catheters are to be advanced at least 20 mm distal to the culprit lesion. After administration of intracoronary nitroglycerine, an IVUS-pullback is to be performed at 0.5mm\u002Fsecond using a commercially available imaging system. Stent size and landing zones are decided based on the IVUS.",[19,23],[35,38,40],{"name":36,"affiliation":5,"role":37},"Thomas Engstrøm, MD PhD DMSci","STUDY_CHAIR",{"name":39,"affiliation":5,"role":37},"Jacob Lønborg, MD PhD DMSci",{"name":41,"affiliation":5,"role":37},"Francis Joshi, Md, PhD",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":11,"email":47},"Thomas Engstrøm, MD PhD DSci","CONTACT","+45 3545 8444","Thomas.Engstroem@regionh.dk",{"name":39,"role":45,"phone":49,"phoneExt":11,"email":50},"+45 3545 8176","jacob.thomsen.loenborg01@regionh.dk",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Heart Center, Rigshospitalet","RECRUITING","Copenhagen","Capital Region","2100","Denmark","DK",{"type":61,"coordinates":62},"Point",[63,64],12.56553,55.67594,{"lat":64,"lon":63},[67,71,74,76,78],{"name":68,"role":45,"phone":69,"phoneExt":11,"email":70},"Thomas Engstrom, MD PhD DSci","+4535458444","thomas.engstroem@rh.regionh.dk",{"name":72,"role":45,"phone":73,"phoneExt":11,"email":50},"Jacob Lønborg","+4535458176",{"name":68,"role":75,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"name":77,"role":75,"phone":11,"phoneExt":11,"email":11},"Jacob T Lønborg, MD PhD DMSci",{"name":79,"role":75,"phone":11,"phoneExt":11,"email":11},"Francis Joshi, MD PhD",{"type":81,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Thomas Engstrom","Professor","100422060","stemi-treatment-optimization-by-ischemic-postconditioning-and-ivus-guidance-100422060",false,"NCT04775914","STEMI Treatment Optimization by Ischemic Postconditioning and IVUS Guidance","The STEMI Optimization Trial - Ischemic Postconditioning (DANAMI4-iPOST) and Intravascular Ultrasound Guided PCI in STEMI (DANAMI4-iSTEMI)","DANAMI4","Inclusion Criteria:\n\n* Age ≥18 years\n* Acute onset of chest pain with \\\u003C12 hours duration\n* STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI.\n\nExclusion Criteria (iPOST2):\n\nPre-PCI TIMI flow 0 or 1 Potential pregnancy Inability to provide informed consent Unwillingness to consent Unavoidable to use thrombectomy Spontaneous coronary artery dissection Time from symptoms onset to PPCI \\> 12 hours Culprit in bypass graft Other reason for not including the patient\n\nExclusion Criteria (iSTEMI):\n\nPotential pregnancy Inability to understand information in order to provide informed consent Unwillingness to consent Spontaneous coronary artery dissection Time from symptoms inset to PPCI \\> 12 hours Culprit in bypass graft Other reason","ALL","18 Years",{"count":95,"type":96},2500,"ESTIMATED","INTERVENTIONAL",[99],"NA","The purpose of is study is to investigate whether ischemic postconditioning (iPOST) and intravascular ultrasound-guided (IVUS) percutaneous coronary intervention (PCI) improve the clinical outcome of patients with ST-segment elevation myocardial infarction treated with primary PCI.",[102],"ST Elevation Myocardial Infarction",[104,105,106],"Primary PCI","Coronary angiography","Intravascular ultra sound (IVUS)","2026-03-24",{"date":109,"type":110},"2026-03-30","ACTUAL",{"date":112,"type":110},"2021-04-01",{"date":114,"type":96},"2031-02-01",{"name":82,"class":6},1]