[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586994":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":36,"locations":42,"responsibleParty":101,"collaborators":105,"id":109,"slug":110,"hasResults":111,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":117,"sex":118,"minAge":119,"maxAge":26,"enrollmentInfo":120,"targetDuration":26,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":26,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Medication","EXPERIMENTAL","This arm includes participants randomly assigned to the medication group. Participants will receive combination nicotine replacement therapy (NRT). The NRT will consist of transdermal patches and nicotine lozenges. Participants will receive study product for 12 weeks.",[13,14],"Drug: Quitting using Medication","Behavioral: Counseling",{"label":16,"type":10,"description":17,"interventionNames":18},"Switching to an E-Cigarette","This arm includes participants randomly assigned to the E-Cigarette Group. Participants will receive a study-provided e-cigarette product for 12 weeks.",[19,14],"Behavioral: Switching to E-Cigarette",[21,27,32],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Switching to E-Cigarette","Participants will receive twelve weeks of e-cigarette products with instructions to switch completely at switch date",[16],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Quitting using Medication","Participants will receive twelve weeks of FDA approved medication, combination NRT, with instructions to quit smoking cigarettes at quit date",[9],{"type":22,"name":33,"description":34,"armGroupLabels":35,"otherNames":26},"Counseling","Participants will recieve brief weekly counseling to support their quit or switch attempt from cigarettes.",[9,16],[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Ela Williams","CONTACT","(843) 876-2090","williela@musc.edu",[43,60,74,88],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"MUSC Charleston, Center for Drug and Alcohol Problems","RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-79.93275,32.77632,{"lat":55,"lon":54},[58],{"name":38,"role":39,"phone":59,"phoneExt":26,"email":41},"843-876-2090",{"facility":61,"status":45,"city":62,"state":47,"zip":63,"country":49,"countryCode":50,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Shoreline Behavioral Health Services","Conway","29526",{"type":52,"coordinates":65},[66,67],-79.04781,33.836,{"lat":67,"lon":66},[70],{"name":71,"role":39,"phone":72,"phoneExt":26,"email":73},"April Lehman","843-698-2767","alehman@shorelinebhs.org",{"facility":75,"status":45,"city":76,"state":47,"zip":77,"country":49,"countryCode":50,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Phoenix Center","Greenville","29607",{"type":52,"coordinates":79},[80,81],-82.39401,34.85262,{"lat":81,"lon":80},[84],{"name":85,"role":39,"phone":86,"phoneExt":26,"email":87},"Daniel Moss","864-898-2992","mossd@musc.edu",{"facility":89,"status":45,"city":90,"state":47,"zip":91,"country":49,"countryCode":50,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Behavioral Health Services of Pickens County","Pickens","29671",{"type":52,"coordinates":93},[94,95],-82.70736,34.88345,{"lat":95,"lon":94},[98],{"name":99,"role":39,"phone":86,"phoneExt":26,"email":100},"Elizabeth Chapman, LPC","chapmanb@musc.edu",{"type":102,"investigatorFullName":103,"investigatorTitle":104,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Erin McClure","Associate Professor-Faculty",[106],{"name":107,"class":108},"National Institute on Drug Abuse (NIDA)","NIH","100586994","steps-substance-use-trial-of-e-cigarettes-or-pharmacotherapy-for-smoking-100586994",false,"NCT06922617","STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking","Evaluating a Tobacco Harm Reduction Strategy Among Clients Enrolled in Substance Use Disorder Treatment","STEPS","Inclusion Criteria:\n\n1. 21+ years of age,\n2. smoke at least 5 cigarettes per day daily or near daily for the past 6 months,\n3. be enrolled in outpatient SUD treatment and have an SUD diagnosis (past or current),\n4. must submit a breath CO sample of ≥ 7 parts per million at screening and a positive instant-read urinary cotinine test,\n5. have had at least one failed smoking quit attempt in their lifetime,\n6. have interest in reducing smoking, quitting smoking, or switching to a less harmful product, and\n7. if female, agrees to use a form of birth control during the study.\n\nExclusion criteria:\n\n1. any significant or unstable medical or psychiatric concern that would affect safety,\n2. current use of pharmacotherapy with smoking cessation efficacy,\n3. pregnant, breastfeeding, or trying to become pregnant,\n4. contraindicated for NRT, and\n5. currently using an ENDS on 20+ days out of the past 30.",true,"ALL","21 Years",{"count":121,"type":122},240,"ESTIMATED","INTERVENTIONAL",[125],"NA","The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching completely to e-cigarettes as compared to FDA-approved medications, namely nicotine replacement therapy in the form of patches and lozenges. Participation will last 6 months and will include five in-person study visits and eleven virtual assessments. Participants will also complete a short daily diary on their phones each day for the first twelve weeks. To qualify, participants must be within 30 days of SUD treatment program admission. This study is being conducted at three outpatient SUD treatment programs across South Carolina. These sites include: 1) the Center for Drug and Alcohol Problems (CDAP) in Charleston, SC, 2) Behavioral Health Services of Pickens County (BHSPC) in Pickens, SC, and 3) Shoreline Behavioral Health Services in Conway, SC. the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and the Medical University of South Carolina in Florence, SC.",[128,129],"Tobacco Use","Substance Use Disorders","2026-04-02",{"date":132,"type":133},"2026-04-03","ACTUAL",{"date":135,"type":133},"2025-10-17",{"date":137,"type":122},"2028-09-01",{"name":5,"class":6},4]