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Accelerator",[60,21,39,42,18,24,66,45,27,30,9,51,63,36,48,15,57,54,33],null,[76],{"name":77,"affiliation":78,"role":79},"Jonathan Leeman, MD","Brigham and Women's Hospital","PRINCIPAL_INVESTIGATOR",[81],{"name":77,"role":82,"phone":83,"phoneExt":74,"email":84},"CONTACT","617-732-6452","JONATHANE_LEEMAN@DFCI.HARVARD.EDU",[86,103],{"facility":87,"status":88,"city":89,"state":90,"zip":91,"country":92,"countryCode":93,"cosmosGeoPoint":94,"geoPoint":99,"contacts":100},"Brigham & Women's Hospital","RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":95,"coordinates":96},"Point",[97,98],-71.05977,42.35843,{"lat":98,"lon":97},[101,102],{"name":77,"role":82,"phone":74,"phoneExt":74,"email":74},{"name":77,"role":79,"phone":74,"phoneExt":74,"email":74},{"facility":104,"status":88,"city":89,"state":90,"zip":91,"country":92,"countryCode":93,"cosmosGeoPoint":105,"geoPoint":107,"contacts":108},"Dana Farber Cancer Institute",{"type":95,"coordinates":106},[97,98],{"lat":98,"lon":97},[109,110],{"name":77,"role":82,"phone":74,"phoneExt":74,"email":74},{"name":77,"role":79,"phone":74,"phoneExt":74,"email":74},{"type":79,"investigatorFullName":77,"investigatorTitle":112,"investigatorAffiliation":5,"oldNameTitle":74,"oldOrganization":74},"Principal Investigator","100371352","stereotactic-magnetic-resonance-guided-radiation-therapy-100371352",false,"NCT04115254","Stereotactic Magnetic Resonance Guided Radiation Therapy","A Master Protocol of Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy (SMART)","Inclusion Criteria:\n\n* Participants must have a confirmed malignancy requiring stereotactic body radiation therapy. See specific disease site cohorts for more details.\n* Tumor size ≤ 7cm\n* Age 18 years of older.\n* ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)\n* Ability to understand and the willingness to sign a written informed consent document.\n* Specific eligibility requirements for each disease site with be covered in each specific cohort.\n\nExclusion Criteria:\n\n* Specific exclusion requirements for each disease site with be covered in each specific cohort\n* History of allergic reactions attributed to gadolinium-based IV contrast.\n\n  \\-- Note: If a patient will not receive contrast, this is not applicable\n* Pregnant women are excluded from this study.\n* Severe claustrophobia or anxiety\n* Participants who cannot undergo an MRI","ALL","18 Years",{"count":123,"type":124},397,"ESTIMATED","INTERVENTIONAL",[127],"NA","This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer.\n\n* The phase 1 study will evaluate the feasibility and safety of delivering SMART in patients with cancer.\n* Phase 2 will evaluate efficacy of SMART with specific reference to tumor control and improvement in patient reported outcome measures",[130,131,132,133,134,135,136,137,138,139,140,141,142],"Pancreas Cancer","Lung Cancer","Renal Cancer","Adrenal Metastases","Prostate Cancer","Liver Metastases","Oligoprogressive Nodal Metastases","Metachronous Nodal Metastases","Synchronous Nodal Metastases","Mesothelioma","Spine Metastases","Brain Metastases","Borderline Resectable Pancreatic Carcinoma",[144,145,130,131,132,133,134,135,146,147,148,149,150,151],"Magnetic Resonance Imaging (MRI)","MRIdian Linear Accelerator","Oligoprogressive","Metachronous","Synchronous","Spine","Prostate Boost","Pelvic Re Irradiation","2025-11-11",{"date":154,"type":155},"2025-11-13","ACTUAL",{"date":157,"type":155},"2019-10-22",{"date":159,"type":124},"2028-06",{"name":5,"class":6},2]