[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641698":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":46,"collaborators":19,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":19,"enrollmentInfo":58,"targetDuration":19,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Medical College of Wisconsin","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"tACS or multisensory stimulation","EXPERIMENTAL","All participants in a within-subject design will receive high-Definition-tACS, delivered via a battery operated alternating current stimulator (Soterix) using two center-surround montages. Targets of stimulation will be localized based on the 10-10 International EEG system with center electrodes placed at a frontal and a temporoparietal site. The current is turned on and increased in a ramplike fashion over approximately 30 seconds. Participants will undergo tACS with frequencies ranging from 4-40Hz for 20-minutes with 2 milliampere (mA) peak-to-peak intensity. For sham stimulation, tACS is turned off after the first 30 seconds.\n\nAll participants will receive light and\u002For sound flicker stimulation using an off-the-shelf app for 20 minutes.",[13],"Device: tACS or multisensory stimulation",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Active or sham tACS Light and\u002For sound flickers",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Priyanka Shah-Basak, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Sidney Schoenrock, MA","CONTACT","414-955-7579","sschoenrock@mcw.edu",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Milwaukee","Wisconsin","53226","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-87.90647,43.0389,{"lat":42,"lon":41},[45],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},{"type":23,"investigatorFullName":22,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Assistant Professor of Neurology","100641698","stimulating-the-aging-brain-using-brain-and-sensory-stimulation-100641698",false,"NCT07650188","Stimulating the Aging Brain Using Brain and Sensory Stimulation","Stimulating the Aging Brain: Noninvasive Brain and Sensory Stimulation Strategies in Aging","StAB","Inclusion Criteria:\n\n* Clinical exam supports diagnosis of PPA and\u002For MCI with no report of difficulty functioning in basic or instrumental activities of daily living.\n* Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit.\n\nExclusion Criteria:\n\n* Evidence of dementia at baseline\n* Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event\n* Age \\\u003C45 years.\n* Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia).\n* Presence of cardiac stimulators or pacemakers\n* Any other implants near the scalp or in the eye\n* Contraindications to MRI or stimulation\n* Pregnancy\n* History of ongoing or unmanaged seizures\n* History of dyslexia or other developmental learning disabilities","ALL","45 Years",{"count":59,"type":60},20,"ESTIMATED","INTERVENTIONAL",[63],"NA","The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA). The main questions it aims to answer are:\n\nDoes transcranial alternating current stimulation (tACS) affect verbal short-term memory (STM) in individuals with PPA? Does a single session of multisensory stimulation affect verbal STM in individuals with PPA? Researchers will compare active tACS to sham tACS (a fake stimulation condition) to see if active tACS improves verbal STM. Researchers will compare pre-multisensory stimulation to post-stimulation performance to see if multisensory stimulation improves verbal STM.\n\nParticipants will:\n\nUndergo EEG, MRI (anatomical and functional) May complete a cognitive exam Undergo tACS over 3 separate sessions Undergo multisensory stimulation Complete language tasks before, during and\u002For after stimulation",[66],"Primary Progressive Aphasia",[68,69],"Transcranial alternating current stimulation","Multisensory stimulation","2026-06-11",{"date":72,"type":73},"2026-06-16","ACTUAL",{"date":75,"type":73},"2026-06-01",{"date":77,"type":60},"2035-05-30",{"name":5,"class":6},1]