[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504886":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":51,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":20,"enrollmentInfo":68,"targetDuration":20,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Acquisition Stimulation Test","EXPERIMENTAL","Single pulse stimulation will be delivered and measured prior to the rating task. Next, subjects perform the Pavlovian fear conditioning paradigm. Participants will be asked to perform a rating task automated on a PC where they continuously update a rating bar using the touchpad to indicate their confidence that a static sound is about to occur on a moment-by-moment basis (0-not confident to 100-very confident). For the stimulation experiment, research staff will explain that electrical stimulation will be applied before the rating task, in isolation, as well as on some trials at controlled time points while the patient performs the rating task",[13],"Procedure: Electrical Pulse Train Stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Electrical Pulse Train Stimulation","sEEG provides the ability to stimulate neural circuits via implanted electrodes by delivering mild intra-cranial electrical stimulations in different brain structures to estimate their impact on cognitive tasks.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Adam Goodman, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Rebekah Chatfield, BS","CONTACT","(205) 975-3477","joyb3@uab.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Epilepsy Monitoring Unit UAB Hospital","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-86.80249,33.52066,{"lat":44,"lon":43},[47,50],{"name":27,"role":28,"phone":48,"phoneExt":20,"email":49},"(205) 975 3477","Joyb3@uab.edu",{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Adam Goodman","Assitant Professor",[55],{"name":56,"class":57},"National Institute of Mental Health (NIMH)","NIH","100504886","stimulation-induced-changes-in-fronto-limbic-network-100504886",false,"NCT05854160","Stimulation-Induced Changes in Fronto-Limbic Network","Stimulation-Induced Changes in Fronto-Limbic Connectivity Control Regulation of the Emotional Response to Threat","Stim_Con","Inclusion Criteria:\n\n* 1\\) implantation of sEEG electrodes for SOC epilepsy surgery evaluation\n* 2\\) cognitive ability to perform simple tasks and to understand instructions\n* 3\\) implanted electrodes in the amygdala and medial PFC regions\n* 4\\) competency to understand and sign a written informed consent.\n\nExclusion Criteria:\n\n* 1\\) an inability to complete the task","ALL","18 Years",{"count":69,"type":70},30,"ESTIMATED","INTERVENTIONAL",[73],"NA","The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.",[76,77],"Epilepsy","Mental Disorders",[79,80,81,82,83,84],"epilepsy","comorbid mental health disorders","sEEG","Anxiety","Fronto-limbic network","Pavlovian fear conditioning paradigm","2026-06-18",{"date":87,"type":88},"2026-06-23","ACTUAL",{"date":90,"type":88},"2023-03-01",{"date":92,"type":70},"2027-02-24",{"name":5,"class":6},1]