[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636482":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":38,"centralContacts":29,"locations":43,"responsibleParty":63,"collaborators":29,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":29,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":29,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":45,"whyStopped":29,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Duke University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Heat Stress","EXPERIMENTAL","Heat stress via 70-80°C sauna exposure for 45-min sessions on 5 consecutive days (days 4-8 or 5-9 of follicular phase).",[13],"Other: Heat stress",{"label":15,"type":10,"description":16,"interventionNames":17},"Sleep Stress","Sleep restriction to 4-6 hours\u002Fnight for 5 consecutive nights (on days 3-8 or 4-9 of follicular phase).",[18],"Other: Sleep stress",{"label":20,"type":10,"description":21,"interventionNames":22},"Exercise Stress","One-hour cycling at 60-75% predicted max HR for 5 consecutive days (days 4-8 or 5-9 of follicular phase).",[23],"Other: Exercise stress",[25,30,34],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Heat stress","Stress-Heat participants will undergo supervised 40-min sessions in a 70-80˚C sauna",[9],null,{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Sleep stress","Stress-Sleep participants will be asked to sleep for between 4 and 6 hours per night, with compliance monitored via their activity monitors and self-reported sleep diaries. Participants will be requested to maintain normal wake cycles without midday sleep.",[15],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":29},"Exercise stress","Stress-Exercise participants will come to the Pontzer Lab to complete a one-hour cycling workout on a Lode Corival CPET ergometer\u002Fexercise bike at 60-75% predicted maximum heart rate.",[20],[39],{"name":40,"affiliation":41,"role":42},"Herman Pontzer, PhD","Duke University Evolutionary Anthropology Department","PRINCIPAL_INVESTIGATOR",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Durham","North Carolina","27708","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-78.89862,35.99403,{"lat":55,"lon":54},[58],{"name":59,"role":60,"phone":61,"phoneExt":29,"email":62},"Mary Joy","CONTACT","7249317802","mary.joy@duke.edu",{"type":64,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100636482","stress-and-menstrual-health-100636482",false,"NCT07566260","Stress and Menstrual Health","The Influence of Non-energetic Stressors on Human Menstrual Function","Inclusion Criteria:\n\n* Adult pre-menopausal females, 18-45 years old\n* Habitually sedentary (less than 60 minutes MVPA\u002Fweek) for Exercise cohort\n\nExclusion Criteria:\n\n* Individuals on hormonal birth control (oral contraception, injection, implant, or intrauterine device)\n* Individuals with incidence in the last 6 months of childbirth, lactation, pregnancy, or functional hypothalamic amenorrhea (FHA)\n* Individuals with reproductive disorders (e.g. endometriosis, polycystic ovarian syndrome (PCOS))\n* Individuals taking thyroid medications\n* Individuals who have undergone or are undergoing menopause\n* MVPA \\>60 min\u002Fweek (for Exercise cohort)",true,"FEMALE","18 Years","45 Years",{"count":77,"type":78},600,"ESTIMATED","INTERVENTIONAL",[81],"NA","The goal of this experimental study is to determine how stressors that do not directly impact energy state or energy demands (hereafter called \"non-energetic stressors\") affect reproductive health in pre-menopausal women. It aims to do this by answering the following main questions: Do non-energetic stressors create a stress response? How does the stress response impact sex hormone concentration and thus menstrual dysfunction? If stress caused by non-energetic stressors does impact sex hormone concentration, does it do so primarily at the level of the brain or the level of the ovary? Participants will be enrolled in this study for 6 months. For two of these months, they will undergo a short stress intervention and provide samples to measure hormone concentration and total energy expenditure.",[84],"Menstrual Dysfunction",[86,87,88],"Stress","Menstruation","Energy Expenditure","2026-06-04",{"date":91,"type":92},"2026-06-05","ACTUAL",{"date":94,"type":92},"2026-05-28",{"date":96,"type":78},"2029-08",{"name":5,"class":6},1]