[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553698":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":32,"locations":41,"responsibleParty":59,"collaborators":11,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":11,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":11,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":44,"whyStopped":11,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Rostock","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Necrosectomy\u002FStrokectomy","EXPERIMENTAL",null,[13],"Procedure: Strokectomy\u002FNecrosectomy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"PROCEDURE","Strokectomy\u002FNecrosectomy","After obtaining CT-\u002FMRT-perfusion, the infarcted area (e.g. infarct core) of malignant MCA-infarction is localized. By using the neuronavigation, surgical resection of necrotic tissue is performed in a non-eloquent area until the space occupying effect is released. At the end of the surgery, the bone flap is reinserted and fixated.",[9],[21,25,28],{"name":22,"affiliation":23,"role":24},"Sae-Yeon Won, MD","Neurosurgery, University Medical Center Rostock","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":23,"role":27},"Florian Gessler, MD PhD","STUDY_DIRECTOR",{"name":29,"affiliation":30,"role":31},"Matthias Wittstock, MD","Neurology, University Medical Center Rostock","STUDY_CHAIR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":11,"email":37},"Melanie Sparre","CONTACT","0381 494 6419","melanie.sparre@med.uni-rostock.de",{"name":22,"role":35,"phone":39,"phoneExt":11,"email":40},"0381 494 146067","sae-yeon.won@med.uni-rostock.de",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"University Medical Center Rostock","RECRUITING","Rostock","Mecklenburg-Vorpommern","18057","Germany","DE",{"type":51,"coordinates":52},"Point",[53,54],12.14049,54.0887,{"lat":54,"lon":53},[57],{"name":58,"role":35,"phone":39,"phoneExt":11,"email":40},"Sae-Yeon Won",{"type":24,"investigatorFullName":58,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Associate Professor","100553698","strokectomy-in-malignant-cerebral-media-infarction-100553698",false,"NCT06489470","Strokectomy in Malignant Cerebral Media Infarction","Strokectomy in Malignant Cerebral Media Infarction: A Pilot Study","Inclusion Criteria:\n\n* 18 years of age or older\n* Ischemic middle cerebral artery (MCA) infarction at least two thirds of the MCA territory\n* Clinical symptoms of acute unilateral MCA infarction less than 48 hours prior to the initiation of treatment\n\nExclusion Criteria:\n\n* Preexisting modified Rankin Scale \\>2\n* Absence of pupillary reflexes or GCS \\\u003C6\n* Intracerebral hemorrhage or other associated brain lesions\n* Contraindications for surgery\n* Estimated life expectancy of less than 3 years","ALL","18 Years",{"count":71,"type":72},10,"ESTIMATED","INTERVENTIONAL",[75],"NA","Decompressive hemicraniectomy (DC) is the standard procedure and life saving measure in case of malignant middle cerebral artery (MCA) infarction. However, there have been several studies reporting the neuroinflammatory cascade based on the necrotic tissue as one of the leading cause for the secondary brain damage, wherefore, strokectomy with resection of necrotic tissue has been proposed in some case series as an alternative surgical option. Thus, the aim of this study is to perform a pilot study by including patients with malignant MCA infarction and to check the feasibility of this specific surgical treatment.",[78],"Stroke, Ischemic",[80,81,82],"necrosectomy","alternative surgical treatment","strokectomy","2024-07-02",{"date":85,"type":86},"2024-07-08","ACTUAL",{"date":88,"type":86},"2024-06-15",{"date":90,"type":72},"2025-06-30",{"name":5,"class":6},1]