[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546539":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":33,"locations":43,"responsibleParty":62,"collaborators":65,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":28,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":28,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":46,"whyStopped":28,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Aalborg University Hospital","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","Sex- and age matched, healthy control. Will only have baseline DKI and MEG performed.",[13,14],"Other: Diffusion Kurtosis Imaging (DKI)","Other: Resting State Magnetoencephalography",{"label":16,"type":10,"description":17,"interventionNames":18},"ALS without PBA","ALS patient without PBA, either at baseline and 6 month follow-up",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"ALS with PBA","ALS patient with PBA, either at baseline or follow-up",[13,14],[24,29],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Diffusion Kurtosis Imaging (DKI)","Non-invasive MRI sequence which extracts information of diffusion signals from complex brain tissue",[20,16,9],null,{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Resting State Magnetoencephalography","Non-invasive method of measuring resting state brain activity through magnetoencephalography (MEG)",[20,16,9],[34,39],{"name":35,"role":36,"phone":37,"phoneExt":28,"email":38},"Christian Holm Steenkjær","CONTACT","+4597660000","c.steenkjaer@rn.dk",{"name":40,"role":36,"phone":41,"phoneExt":28,"email":42},"Blicher","+4522144295","Au568472@uni.au.dk",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Aalborg University hospital","RECRUITING","Aalborg","Northern Jutland","9500","Denmark","DK",{"type":53,"coordinates":54},"Point",[55,56],9.9187,57.048,{"lat":56,"lon":55},[59],{"name":60,"role":36,"phone":61,"phoneExt":28,"email":28},"Christian Steenkjaer","22144295",{"type":63,"investigatorFullName":35,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","Principal Investigator",[66],{"name":67,"class":6},"University of Aarhus","100546539","structural-and-functional-networks-in-als-an-insight-into-pseudobulbar-affect-100546539",false,"NCT06396260","Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect","Inclusion Criteria:\n\n* Diagnosed with ALS in the last 6 months according to Gold Coast Criteria\n\nExclusion Criteria:\n\n* \\- Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and\u002For tablet, or through telephone interview.\n* Lack of ability to cooperate.\n* Pregnancy\n* Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics.\n* Alcohol addiction defined as over 21 units weekly.\n* Lesional neurological diseases, such as stroke, tumor or multiple sclerosis\n* Epilepsy\n* Neurodegenerative diseases other than ALS\n* Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia\n* Contraindication for MRI and MEG scan according to hospital guidelines\n* Severe liver or kidney disease\n* Dysregulated heart disease\n* Ongoing treatment with any antidepressants or any antipsychotics at recruitment.\n* Diagnosed with frontotemporal dementia.",true,"ALL","18 Years","90 Years",{"count":79,"type":80},50,"ESTIMATED","INTERVENTIONAL",[83],"NA","The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).",[86,87],"Amyotrophic Lateral Sclerosis","Pseudobulbar Affect",[89,90,91],"Diffusion Kurtosis Imaging","Magnetoencephalography","Connectivity","2025-01-28",{"date":94,"type":95},"2025-01-29","ACTUAL",{"date":97,"type":95},"2024-05-26",{"date":99,"type":80},"2026-12-31",{"name":5,"class":6},1]